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Enzyme-Responsive Nanoparticles for the Treatment of Disease

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Biomedical Nanotechnology

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1570))

Abstract

Nanomedicine for cancer therapy seeks to treat malignancies through the selective accumulation of therapeutics in diseased tissue. Nanoparticles offer the convenience of high drug loading capacities and can be readily decorated with targeting moieties, drugs, and/or diagnostics. Our lab has pioneered a new tissue targeting strategy where enhanced accumulation of nanomaterials occurs as a result of morphology changes to the material in response to overexpressed enzymes in diseased tissues. Herein, we describe the general strategy for the preparation of these enzyme-responsive nanoparticles (ER-NPs) for therapeutic applications.

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Author information

Authors and Affiliations

  1. Department of Chemistry and Biochemistry, University of California–San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA

    Cassandra E. Callmann & Nathan C. Gianneschi

Authors
  1. Cassandra E. Callmann
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  2. Nathan C. Gianneschi
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Corresponding author

Correspondence to Nathan C. Gianneschi .

Editor information

Editors and Affiliations

  1. Department of Chemistry and International Institute for Nanotechnology, Northwestern University, Evanston, Illinois, USA

    Sarah Hurst Petrosko

  2. Department of Biomedical Engineering, University of Delaware, Newark, Delaware, USA

    Emily S. Day

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Callmann, C.E., Gianneschi, N.C. (2017). Enzyme-Responsive Nanoparticles for the Treatment of Disease. In: Petrosko, S., Day, E. (eds) Biomedical Nanotechnology. Methods in Molecular Biology, vol 1570. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-6840-4_15

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  • DOI: https://doi.org/10.1007/978-1-4939-6840-4_15

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-6838-1

  • Online ISBN: 978-1-4939-6840-4

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