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Magnetic Resonance Imaging in Experimental Traumatic Brain Injury

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Injury Models of the Central Nervous System

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1462))

Abstract

Traumatic brain injury (TBI) is a leading cause of death and disability in the USA. Common causes of TBI include falls, violence, injuries from wars, and vehicular and sporting accidents. The initial direct mechanical damage in TBI is followed by progressive secondary injuries such as brain swelling, perturbed cerebral blood flow (CBF), abnormal cerebrovascular reactivity (CR), metabolic dysfunction, blood–brain-barrier disruption, inflammation, oxidative stress, and excitotoxicity, among others. Magnetic resonance imaging (MRI) offers the means to noninvasively probe many of these secondary injuries. MRI has been used to image anatomical, physiological, and functional changes associated with TBI in a longitudinal manner. This chapter describes controlled cortical impact (CCI) TBI surgical procedures, a few common MRI protocols used in TBI imaging, and, finally, image analysis pertaining to experimental TBI imaging in rats.

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Acknowledgements

This work is supported in part by NIH/NINDS R01 NS45879, a TL1 and KL2 TR001118, and Mike Hogg Fund via the Clinical Translational Science Awards (CTSA, parent grants UL1TR000149, TL1TR001119, and KL2TR001118). We thank our former and current colleagues who have participated on these TBI projects.

Author information

Authors and Affiliations

  1. Research Imaging Institute, University of Texas Health Science Center, 8403 Floyd Curl Dr, San Antonio, TX, 78229, USA

    Qiang Shen Ph.D., Lora Tally Watts, Wei Li & Timothy Q. Duong Ph.D.

  2. Department of Ophthalmology, University of Texas Health Science Center, San Antonio, TX, USA

    Qiang Shen Ph.D., Wei Li & Timothy Q. Duong Ph.D.

  3. Department of Radiology, University of Texas Health Science Center, San Antonio, TX, USA

    Qiang Shen Ph.D. & Timothy Q. Duong Ph.D.

  4. Departments of Cellular and Structure Biology, University of Texas Health Science Center, San Antonio, TX, USA

    Lora Tally Watts

  5. Department of Veterans Affairs, South Texas Veterans Health Care System, San Antonio, TX, USA

    Timothy Q. Duong Ph.D.

Authors
  1. Qiang Shen Ph.D.
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  2. Lora Tally Watts
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  3. Wei Li
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  4. Timothy Q. Duong Ph.D.
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Corresponding authors

Correspondence to Qiang Shen Ph.D. or Timothy Q. Duong Ph.D. .

Editor information

Editors and Affiliations

  1. Banyan Biomarkers, Inc., Alachua, Florida, USA

    Firas H. Kobeissy

  2. Safar Center for Resuscitation Research, University of Pittsburgh Safar Center for Resuscitation Research, Pittsburgh, Pennsylvania, USA

    C. Edward Dixon

  3. Banyan Biomarkers, Inc. , Alachua, Florida, USA

    Ronald L. Hayes

  4. Banyan Biomarkers, Inc., Alachua, Florida, USA

    Stefania Mondello

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Shen, Q., Watts, L.T., Li, W., Duong, T.Q. (2016). Magnetic Resonance Imaging in Experimental Traumatic Brain Injury. In: Kobeissy, F., Dixon, C., Hayes, R., Mondello, S. (eds) Injury Models of the Central Nervous System. Methods in Molecular Biology, vol 1462. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-3816-2_35

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  • DOI: https://doi.org/10.1007/978-1-4939-3816-2_35

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-3814-8

  • Online ISBN: 978-1-4939-3816-2

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