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Oligodendrocytes: Cells of Origin for White Matter Injury in the Developing Brain

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Prenatal and Postnatal Determinants of Development

Part of the book series: Neuromethods ((NM,volume 109))

Abstract

A prominent pattern of brain injury in preterm born infants involves damage to white matter with impaired oligodendrocyte maturation. This results in diffuse deficits in myelination that are associated with later development of cerebral palsy. While numerous experimental animal models of perinatal white matter injury have been developed, they show a spectrum of effects. This review proposes that adopting a more standard approach to defining white matter injury is important for validating experimental findings against the bona fide human condition. This chapter will describe the pathology of perinatal white matter injury and a general methodological approach for assessing white matter injury experimentally.

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Acknowledgments

MT is supported by the National Health and Medical Research Council of Australia and a Career Development Grant awarded by the Research Foundation, Cerebral Palsy Alliance. DHR is a HHMI investigator. JD is supported by grants from the Health Research Council of New Zealand, the Marsden Fund, and the Auckland Medical Research Foundation.

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Authors and Affiliations

  1. School of Health Sciences, Health Innovations Research Institute, RMIT University, Bundoora Campus, VIC, Australia

    Mary Tolcos

  2. Department of Pediatrics, Eli and Edythe Broad Institute for Stem Cell Research and Regeneration Medicine and Howard Hughes Medical Institute, University of California, San Francisco, CA, 94143, USA

    David H. Rowitch

  3. Division of Neonatology, University of California, San Francisco, San Francisco, CA, 94143, USA

    David H. Rowitch

  4. Department of Physiology, University of Auckland, Auckland, New Zealand

    Justin Dean

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  1. Mary Tolcos
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  2. David H. Rowitch
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  3. Justin Dean
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Correspondence to Mary Tolcos .

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Editors and Affiliations

  1. Hudson Institute of Medical Research, Monash Medical Centre, The Ritchie Centre, Melbourne, Australia

    David W. Walker

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Tolcos, M., Rowitch, D.H., Dean, J. (2016). Oligodendrocytes: Cells of Origin for White Matter Injury in the Developing Brain. In: Walker, D. (eds) Prenatal and Postnatal Determinants of Development. Neuromethods, vol 109. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-3014-2_14

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  • DOI: https://doi.org/10.1007/978-1-4939-3014-2_14

  • Publisher Name: Humana Press, New York, NY

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