Abstract
Patients with the human immunodeficiency virus (HIV) have a greatly increased risk of kidney disease, due in part to HIV-associated nephropathy and commonly used nephrotoxic medications. The cutaneous manifestations of HIV are a vast spectrum of disorders including exaggerated or atypical presentations of common diseases, opportunistic infections, and adverse medication reactions. A dermatologic sign or symptom may be the first presentation of an occult HIV infection. Many cutaneous manifestations of HIV are correlated with CD4 T-cell count, such that skin diseases may progress more rapidly or present in an atypical fashion as immune status deteriorates. The introduction of effective antiretroviral treatment has modified the course of the disease while simultaneously introducing its own complications including medication reactions, lipodystrophy syndrome, and the immune reconstitution syndrome.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsAbbreviations
- AIDS:
-
Acquired immune deficiency syndrome
- EF:
-
Eosinophilic folliculitis
- FTA-ABS:
-
Fluorescent treponemal antibody-absorption
- HAART:
-
Highly active antiretroviral therapy
- HIV:
-
Human immunodeficiency virus
- HLA:
-
Human leukocyte antigen
- HPV:
-
Human papillomavirus
- HSV:
-
Herpes simplex virus
- IRIS:
-
Immune reconstitution inflammatory syndrome
- KS:
-
Kaposi sarcoma
- PCR:
-
Polymerase chain reaction
- PPE:
-
Pruritic papular eruption
- PUVA:
-
Psoralen plus ultraviolet A
- RPR:
-
Rapid plasma reagin
- UVB:
-
Ultraviolet B
- VZV:
-
Varicella zoster virus
References
De Cock KM, Jaffe HW, Curran JW. The evolving epidemiology of HIV/AIDS. AIDS. 2012;26:1205.
Hogan MT. Cutaneous infections associated with HIV/AIDS. Dermatol Clin. 2006;24:473.
Nnoruka EN, Chukwuka JC, Anisuiba B. Correlation of mucocutaneous manifestations of HIV/AIDS infection with CD4 counts and disease progression. Int J Dermatol. 2007;46:14.
Cedeno-Laurent F, Gomez-Flores M, Mendez N, et al. New insights into HIV-1-primary skin disorders. J Int AIDS Soc. 2011;14:5.
Islam FM, Wu J, Jansson J, et al. Relative risk of renal disease among people living with HIV: a systematic review and meta-analysis. BMC Public Health. 2012;12:234.
Miro JM, Cofan F, Trullas JC, et al. Renal dysfunction in the setting of HIV/AIDS. Curr HIV/AIDS Rep. 2012;9:187.
Wyatt CM. The kidney in HIV infection: beyond HIV-associated nephropathy. Top Antiviral Med. 2012;20(3):106.
Khambaty MM, Hsu SS. Dermatology of the patient with HIV. Emerg Med Clin N Am. 2010;28:355.
Hulsebosch HJ, Claessen FA, VanGinkel CJ, et al. Human immunodeficiency virus exanthem. J Am Acad Dermatol. 1990;23:483.
Abrams DI. Clinical manifestations of HIV infection, including persistent generalized lymphadenopathy and AIDS-related complex. J Am Acad Dermatol. 1990;22:1217.
Rodgers S, Leslie KS. Skin infections in HIV-infected individuals in the era of HAART. Curr Opin Infect Dis. 2011;24:124.
Gormley R, Kovarik C. Dermatologic manifestations of HPV in HIV-infected individuals. Curr HIV/AIDS Rep. 2009;6:130.
Maurer T. Dermatologic manifestations of HIV infection. Top HIV Med. 2005;13(5):149.
Toro JR, Wood LV, Patel NK, et al. Topical cidofovir: a novel treatment for recalcitrant molluscum contagiosum in children infected with human immunodeficiency virus 1. Arch Dermatol. 2000;136(8):983.
Theiler M, Kempf W, Kerl K, et al. Disseminated molluscum contagiosum in a HIV-positive child: improvement after therapy with 5% imiquimod. J Dermatol Case Rep. 2011;5(2):19.
Sadick N, Sorhaindo L. A comparative split-face study of cryosurgery and trichloroacetic acid 100% peels in the treatment of HIV-associated disseminated facial molluscum contagiosum. Cutis. 2009;83(6):299.
Golden MR, Marra CM, Homes KK. Update on syphilis: resurgence of an old problem. JAMA. 2003;290(11):1510–4.
Gregory N, Sanchez M, Buchness MR. The spectrum of syphilis in patients with human immunodeficiency virus infection. J Am Acad Dermatol. 1990;22(6 Pt 1):1061–7.
Gasquet S, Maurin M, Brouqui P, et al. Bacillary angiomatosis by Bartonella quintana in an HIV-infected patient. J Am Acad Dermatol. 2000;42(2):299–301.
Zancanaro PC, McGirt LY, Mammelak AJ, et al. Cutaneous manifestations of HIV in the era of highly active antiretroviral therapy: an institutional urban clinic experience. J Am Acad Dermatol. 2006;54(4):581–8.
Smith KJ, Skelton HG, Yeager J, et al. Cutaneous findings in HIV-1 positive patients: a 42-month prospective study. J Am Acad Dermatol. 1994;31:746–54.
Gupta AK, Bluhm R. Seborrheic dermatitis. J Eur Acad Dermatol Venereol. 2004;18(1):13–26.
Mallon E, Bunker CB. HIV-associated psoriasis. AIDS Patient Care Stds. 2000;14:239–46.
Morar N, Willis-Owen SA, Maurer T, et al. HIV-associated psoriasis: pathogenesis, clinical features, and management. Lancet Infect Dis. 2010;10(7):470–8.
Menon K, Van Voorhees AS, Bebo BF, et al. Psoriasis in patients with HIV infection: from the medical board of the National Psoriasis Foundation. J Am Acad Dermatol. 2010;62(2):291–9.
Ting PT, Koo JY. Use of etanercept in human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS) patients. Int J Dermatol. 2006;45(6):689–92.
Afonso JP, Tomimori J, Michalany NS, et al. Pruritic papular eruption and eosinophilic folliculitis associated with human immunodeficiency virus (HIV) infection: a histopathological and immunohistochemical comparative study. J Am Acad Dermatol. 2012;67(2):269–75.
Fearfield LA, Rowe A, Francis N, et al. Itchy folliculitis and human immunodeficiency virus infection: clinicopathological and immunological features, pathogenesis and treatment. Br J Dermatol. 1999;141:3–11.
Chang Y, Cesarman E, Pessin MS, et al. Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi’s sarcoma. Science. 1994;266:1865–9.
Schwartz RA, Micali G, Nasca MR, et al. Kaposi sarcoma: a continuing conundrum. J Am Acad Dermatol. 2008;59(2):179–206.
Friedman-Kien AE, Saltzman BR. Clinical manifestations of classical, endemic African, and epidemic AIDS-associated Kaposi’s sarcoma. J Am Acad Dermatol. 1990;22(6 Pt 2):1237–50.
Costner M, Cockerell CJ. The changing spectrum of the cutaneous manifestations of HIV disease. Arch Dermatol. 1998;134:1290.
Aldenhoven M, Barlo NP, Sanders CJ. Therapeutic strategies for epidemic Kaposi’s sarcoma. Int J STD AIDS. 2006;17:571–8.
Ng’andwe C, Lowe J, Richards P, et al. The distribution of sexually transmitted human papillomaviruses in HIV positive and negative patients in Zambia. Afr BMC Infect Dis. 2007;7:77.
Darragh T, Winkler B. Anal cancer and cervical cancer screening: key differences. Cancer Cytopathol. 2011;119:5–19.
Introcaso CE, Hines JM, Kovarik CL. Cutaneous toxicities of antiretroviral therapy for HIV. Part I. Lipodystrophy syndrome, nucleoside reverse transcriptase inhibitors, and protease inhibitors. J Am Acad Dermatol. 2010;63(4):549–61.
Saavedra A, Johnson RA. Cutaneous manifestations of human immunodeficiency virus disease. In: Wolff K, Goldsmith LA, Katz SI, et al., editors. Fitzpatrick’s dermatology in general medicine. 7th ed. New York, NY: McGraw-Hill; 2008. p. 1927–40.
Introcaso CE, Hines JM, Kovarik CL. Cutaneous toxicities of antiretroviral therapy for HIV. Part II. Nonnucleoside reverse transcriptase inhibitors, entry and fusion inhibitors, integrase inhibitors, and immune reconstitution syndrome. J Am Acad Dermatol. 2010;63(4):563–9.
Lyher J, Glesby MJ. Dermatologic adverse effects of antiretroviral therapy: recognition and management. Am J Clin Dermatol. 2007;8:221–33.
Murdoch DM, Venter WDF, Van Rie A, et al. Immune reconstitution inflammatory syndrome. AIDS Res Ther. 2007;4:1–9.
Shelburne SA, Hamill RJ, Rodríguez-Barradas MC, et al. Immune reconstitution inflammatory syndrome: emergence of a unique syndrome during highly active antiretroviral therapy. Medicine (Baltimore). 2002;81:213–27.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2015 Springer Science+Business Media New York
About this chapter
Cite this chapter
Winslow, C.Y., Kerdel, F.A. (2015). Human Immunodeficiency Virus. In: Nunley, J., Lerma, E. (eds) Dermatological Manifestations of Kidney Disease. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-2395-3_4
Download citation
DOI: https://doi.org/10.1007/978-1-4939-2395-3_4
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4939-2394-6
Online ISBN: 978-1-4939-2395-3
eBook Packages: MedicineMedicine (R0)