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IMGT/HLA and the Immuno Polymorphism Database

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Immunoinformatics

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1184))

Abstract

The IMGT/HLA Database (http://www.ebi.ac.uk/ipd/imgt/hla/) was first released over 15 years ago, providing the HLA community with a searchable repository of highly curated HLA sequences. The HLA complex is located within the 6p21.3 region of human chromosome 6 and contains more than 220 genes of diverse function. Many of the genes encode proteins of the immune system and are highly polymorphic, with some genes currently having over 3,000 known allelic variants. The Immuno Polymorphism Database (IPD) (http://www.ebi.ac.uk/ipd/) expands on this model, with a further set of specialist databases related to the study of polymorphic genes in the immune system. The IPD project works with specialist groups or nomenclature committees who provide and curate individual sections before they are submitted to IPD for online publication. IPD currently consists of four databases: IPD-KIR contains the allelic sequences of killer-cell immunoglobulin-like receptors; IPD-MHC is a database of sequences of the major histocompatibility complex of different species; IPD-HPA, alloantigens expressed only on platelets; and IPD-ESTDAB, which provides access to the European Searchable Tumour Cell-Line Database, a cell bank of immunologically characterized melanoma cell lines. Through the work of the HLA Informatics Group and in collaboration with the European Bioinformatics Institute we are able to provide public access to this data through the website http://www.ebi.ac.uk/ipd/.

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Acknowledgements

The authors would like to thank Angie Dahl of the Be The Match Foundation for her continuing work in securing ongoing funding for the IMGT/HLA Database. We would like to thank all of the individuals and organizations that support our work financially.

The authors would also like to thank Shirley Ellis, John Hammond, Chak-Sum Ho, Lorna Kennedy, Hans Dijkstra, Natasja de Groot, Nel Otting and Ronald Bontrop, Lutz Walter, Keith Ballingall, Donald Miller, Paul Metcalfe, Nick Watkins, Graham Pawelec, Libby Guethlein, Peter Parham, Jeff Miller, and Sarah Cooley for their involvement in the IPD project.

Finally the authors would like to thank Rodigo Lopez and Hamish McWilliam and the European Bioinformatics Institute for technical and infrastructure support.

Funding: This work was supported by Histogenetics; One Lambda Inc.; Conexio; Abbott Molecular Laboratories Inc.; Life Technologies; the American Society for Histocompatibility and Immunogenetics; DKMS; Olersup SSP; 454 Sequencing; Lab Corp; Lifecodes + Immunocor Gamma; the European Federation for Immunogenetics; Zentrum Knochenmarkspender-Register Deutschland; Anthony Nolan; the Asia-Pacific Histocompatibility and Immunogenetics Association; BAG Healthcare; Be the Match Foundation; the National Marrow Donor Program; Rose; Inno-train Diagnostik GMBH; and GenDX. Initial support for the IMGT/HLA Database project was from the Imperial Cancer Research Fund (now Cancer Research UK) and a EU Biotech grant (BIO4CT960037).

Author information

Authors and Affiliations

  1. Anthony Nolan Research Institute, Royal Free Hospital, Pond Street, Hampstead, London, NW3 2QG, UK

    James Robinson, Jason A. Halliwell & Steven G. E. Marsh

  2. UCL Cancer Institute, University College London, Royal Free Campus, Pond Street, Hampstead, London, NW3 2QG, UK

    James Robinson & Steven G. E. Marsh

Authors
  1. James Robinson
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  2. Jason A. Halliwell
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  3. Steven G. E. Marsh
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Corresponding author

Correspondence to Steven G. E. Marsh .

Editor information

Editors and Affiliations

  1. Indian Statistical Institute, Kolkata, West Bengal, India

    Rajat K. De

  2. Indian Statistical Institute, Kolkata, West Bengal, India

    Namrata Tomar

Appendix. Access and Contact

Appendix. Access and Contact

IMGT/HLA homepage: http://www.ebi.ac.uk/ipd/

IMGT/HLA FTP site: ftp://ftp.ebi.ac.uk/pub/databases/ipd/

Contact: hla@alleles.org

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Robinson, J., Halliwell, J.A., Marsh, S.G.E. (2014). IMGT/HLA and the Immuno Polymorphism Database. In: De, R., Tomar, N. (eds) Immunoinformatics. Methods in Molecular Biology, vol 1184. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-1115-8_5

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  • DOI: https://doi.org/10.1007/978-1-4939-1115-8_5

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