Abstract
Transcranial magnetic stimulation (TMS) is a technique that is constantly evolving. Today, not only are there a number of technical options to consider, but also a number of methodological and experimental options. In this chapter, we supply a comprehensive overview of these many considerations. We first examine the physical and hardware foundations of TMS (including electromagnetic induction, stimulator characteristics, and coil variations). Following this, we briefly outline the most utilized and efficacious stimulation paradigms (including varied single and repetitive pulse patterns). Finally, we offer several practical procedural techniques universal to all devices and protocols.
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Barker AT, Jalinous R, Freeston IL (1985) Non-invasive magnetic stimulation of human motor cortex. Lancet 325:1106–1107
Pascual-Leone A, Davey M, Wassermann EM, Rothwell J, Puri B (eds) (2002) Handbook of transcranial magnetic stimulation. Edward Arnold, London
Rotenberg A (2010) Prospects for clinical applications of transcranial magnetic stimulation and real-time EEG in epilepsy. Brain Topogr 22(4):257–266
Horvath JC, Perez JM, Forrow L, Fregni F, Pascual-Leone A (2011) Transcranial magnetic stimulation: a historical evaluation and future prognosis of therapeutically relevant ethical concerns. J Med Ethics 37(3):137–143
Kobayashi M, Pascual-Leone A (2003) Transcranial magnetic stimulation in neurology. Lancet Neurol 2(3):145–156
Fitzgerald PB, Fountain S, Daskalakis ZJ (2006) A comprehensive review of the effects of rTMS on motor cortical excitability and inhibition. Clin Neurophysiol 117(12):2584–2596
Valero-Cabré A, Pascual-Leone A, Coubard OA (2011) Transcranial magnetic stimulation (TMS) in basic and clinical neuroscience research. Neurol Rev 167(4):291–316
Najib U, Bashir S, Edwards D, Rotenberg A, Pascual-Leone A (2011) Transcranial brain stimulation: clinical applications and future directions. Neurosurg Clin N Am 22(2):233
Faraday M (1839) Experimental researches in electricity, vol 1. Bernard Quaritch, London
Hallett M (2000) Transcranial magnetic stimulation and the human brain. Nature 406(6792):147–150
Deng ZD, Lisanby SH, Peterchev AV (2012) Electric field depth–focality tradeoff in transcranial magnetic stimulation: simulation comparison of 50 coil designs. Brain Stimul 6(1):1–13
Wagner TA, Zahn M, Grodzinsky AJ, Pascual-Leone A (2004) Three-dimensional head model simulation of transcranial magnetic stimulation. Biomed Eng IEEE Trans 51(9):1586–1598
Roth Y, Amir A, Levkovitz Y, Zangen A (2007) Three-dimensional distribution of the electric field induced in the brain by transcranial magnetic stimulation using figure-8 and deep H-coils. J Clin Neurophysiol 24(1):31–38
Amassian VE, Eberle L, Maccabee PJ, Cracco RQ (1992) Modelling magnetic coil excitation of human cerebral cortex with a peripheral nerve immersed in a brain-shaped volume conductor: the significance of fiber bending in excitation. Electroencephalogr Clin Neurophysiol 85(5):291–301
Maccabee PJ, Amassian VE, Eberle LP, Cracco RQ (1993) Magnetic coil stimulation of straight and bent amphibian and mammalian peripheral nerve in vitro: locus of excitation. J Physiol 460(1):201–219
Wagner T, Valero-Cabre A, Pascual-Leone A (2007) Noninvasive human brain stimulation. Annu Rev Biomed Eng 9:527–565
Peterchev AV, Jalinous R, Lisanby SH (2008) A transcranial magnetic stimulator inducing near-rectangular pulses with controllable pulse width (cTMS). Biomed Eng IEEE Trans 55(1):257–266
Barker AT, Freeston IL, Jalinous R, Jarratt JA (1987) Magnetic stimulation of the human brain and peripheral nervous system: an introduction and the results of an initial clinical evaluation. Neurosurgery 20:100–109
Dantec (2003) Instruction manual. Dantec Medical A/S, Skovlunde, DK
Sommer M, Alfaro A, Rummel M, Speck S, Lang N, Tings T, Paulus W (2006) Half sine, monophasic and biphasic transcranial magnetic stimulation of the human motor cortex. Clin Neurophysiol 117(4):838–844
Chen R, Cros D, Curra A, Di Lazzaro V, Lefaucheur JP, Magistris MR, Mills K, Rösler KM, Triggs WJ, Ugawa Y, Ziemann U (2008) The clinical diagnostic utility of transcranial magnetic stimulation: report of an IFCN committee. Clin Neurophysiol 119(3):504–532
Muri RM, Vermersch AI, Rivaud S, Gaymard B, Pierrot-Deseilligny C (1996) Effects of single-pulse transcranial magnetic stimulation over the prefrontal and posterior parietal cortices during memory-guided saccades in humans. J Neurophysiol 76(3):2102–2106
Amassian VE, Cracco RQ, Maccabee PJ, Cracco JB, Rudell AP, Eberle L (1998) Transcranial magnetic stimulation in study of the visual pathway. J Clin Neurophysiol 15(4):288–304
Thut G, Northoff G, Ives JR, Kamitani Y, Pfennig A, Kampmann F, Schomer DL, Pascual-Leone A (2003) Effects of single-pulse transcranial magnetic stimulation (TMS) on functional brain activity: a combined event-related TMS and evoked potential study. Clin Neurophysiol 114(11):2071–2080
Rothwell JC (1997) Techniques and mechanisms of action of transcranial stimulation of the human motor cortex. J Neurosci Methods 74(2):113–122
Chen R (2000) Studies of human motor physiology with transcranial magnetic stimulation. Muscle Nerve Suppl 9:S26–S32
Merabet LB, Theoret H, Pascual-Leone A (2003) Transcranial magnetic stimulation as an investigative tool in the study of visual function. Optom Vis Sci 80(5):356–368
Rothwell JC (1999) Paired-pulse investigations of short-latency intracortical facilitation using TMS in humans. Electroencephalogr Clin Neurophysiol Suppl 51:113–119
Currà A, Modugno N, Inghilleri M, Manfredi M, Hallett M, Berardelli A (2002) Transcranial magnetic stimulation techniques in clinical investigation. Neurology 59(12):1851–1859
Chen R, Classen J, Gerloff C, Celnik P, Wassermann EM, Hallett M, Cohen LG (1997) Depression of motor cortex excitability by low‐frequency transcranial magnetic stimulation. Neurology 48(5):1398–1403
Guse B, Falkai P, Wobrock T (2010) Cognitive effects of high-frequency repetitive transcranial magnetic stimulation: a systematic review. J Neural Transm 117(1):105–122
Huang YZ, Edwards MJ, Rounis E, Bhatia KP, Rothwell JC (2005) Theta burst stimulation of the human motor cortex. Neuron 45(2):201–206
Chen R, Udupa K (2009) Measurement and modulation of plasticity of the motor system in humans using transcranial magnetic stimulation. Mot Control 13(4):442–453
Pascual-Leone A, Walsh V, Rothwell J (2000) Transcranial magnetic stimulation in cognitive neuroscience–virtual lesion, chronometry, and functional connectivity. Curr Opin Neurobiol 10(2):232–237
Terao Y, Ugawa Y (2006) Studying higher cerebral functions by transcranial magnetic stimulation. Suppl Clin Neurophysiol 59:9–17
Ni Z, Müller-Dahlhaus F, Chen R, Ziemann U (2011) Triple-pulse TMS to study interactions between neural circuits in human cortex. Brain Stimul 4(4):281–293
Hamada M, Terao Y, Hanajima R, Shirota Y, Nakatani-Enomoto S, Furubayashi T, Matsumoto H, Ugawa Y (2008) Bidirectional long-term motor cortical plasticity and metaplasticity induced by quadripulse transcranial magnetic stimulation. J Physiol 586(16):3927–3947
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Rotenberg, A., Horvath, J.C., Pascual-Leone, A. (2014). The Transcranial Magnetic Stimulation (TMS) Device and Foundational Techniques. In: Rotenberg, A., Horvath, J., Pascual-Leone, A. (eds) Transcranial Magnetic Stimulation. Neuromethods, vol 89. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-0879-0_1
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DOI: https://doi.org/10.1007/978-1-4939-0879-0_1
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