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Flavins and Flavoproteins pp 113–157Cite as

Flavins and Flavoproteins: Applications in Medicine

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 1146))

Abstract

The potential of flavoproteins as targets of pharmacological treatments is immense. In this review we present an overview of the current research progress on medical interventions based on flavoproteins with a special emphasis on cancer, infectious diseases, and neurological disorders.

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Abbreviations

5-HT:

Serotonin

ALS:

Amyotrophic lateral sclerosis

AR:

Androgen receptor

DA:

Dopamine

DAAO:

d-amino acid oxidase

DHODH:

Dihydroorotate dehydrogenase

ER:

Estrogen receptor

FAD:

Flavin adenine dinucleotide

FMN:

Flavin mononucleotide

GR:

Glutathione reductase

Grx:

Glutaredoxin

GSH:

Reduced glutathione

GSSG:

Oxidized glutathione

HDAC:

Histone deacetylase

LipDH:

Lipoamide dehydrogenase

LSD:

Lysine specific demethylase

MAO:

Monoamine oxidase

MGd:

Motexafin gadolinium

NQO1:

NAD(P)H:quinone oxidoreductase 1

NE:

Norepinephrine

NMDAR:

N-methyl d-aspartate receptor

NOX:

NADPH oxidases

NuRD:

Mi-2/nucleosome remodeling and deacetylase complex

PEA:

Phenylethylamine

Prx:

Peroxiredoxins

RIMA:

Reversible inhibitors of MAO-A

RNR:

Ribonucleotide reductase

ROS:

Reactive oxygen species

Sec:

Selenocysteine

SecTRAP:

Selenium compromised thioredoxin reductase-derived apoptotic proteins

TGFβ1:

Transforming growth factor-β1

TGR:

Thioredoxin glutathione reductase

ThyX:

Thymidylate synthase

TR:

Trypanothione reductase

Trx:

Thioredoxin

TrxR:

Thioredoxin reductase

XO:

Xanthine oxidase

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Acknowledgements

The authors wish to thank the Deutsche Forschungsgemeinschaft (DFG, BE1540/15-1) for supporting their work.

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Authors and Affiliations

  1. Interdisciplinary Research Center, Justus Liebig University, Giessen, Germany

    Esther Jortzik, Lihui Wang, Jipeng Ma & Katja Becker

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  1. Esther Jortzik
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  2. Lihui Wang
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  3. Jipeng Ma
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  4. Katja Becker
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Correspondence to Katja Becker .

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Editors and Affiliations

  1. Institut für Physikalische Chemie, Albert-Ludwigs-Universität Freiburg, Germany

    Stefan Weber

  2. Institut für Physikalische Chemie, Albert-Ludwigs-Universität Freiburg, Germany

    Erik Schleicher

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Jortzik, E., Wang, L., Ma, J., Becker, K. (2014). Flavins and Flavoproteins: Applications in Medicine. In: Weber, S., Schleicher, E. (eds) Flavins and Flavoproteins. Methods in Molecular Biology, vol 1146. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-0452-5_7

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  • DOI: https://doi.org/10.1007/978-1-4939-0452-5_7

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