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Nuclear Envelope Regulation of Signaling Cascades

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Cancer Biology and the Nuclear Envelope

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 773))

Abstract

The ultimate purpose of signal transduction is to transmit extracellular or cytoplasmic stimuli to the nuclear interior to elicit a cellular response, mediated primarily through changes in gene expression. The evolution of the nuclear envelope and the consequent compartmentalization of the genome, which is a defining feature of eukaryotes, introduced a physical barrier to the free access of genes. Initially regarded as nothing more than this, a physical barrier with selective permeability, recent findings have transformed our view of the nuclear envelope and its diverse roles in various aspects of cell biology and human diseases, much of which is only beginning to be understood. The realization that mutations in genes encoding nuclear envelope proteins cause a diverse array of tissue-selective diseases often referred to as “laminopathies” has provided new insight into structural and regulatory functions of the nuclear envelope. Genetic mutations causing abnormalities in the nuclear envelope can lead to dysregulated signaling that underlies pathogenesis of these diseases. The emerging picture indicates that the nuclear envelope is a node that fine-tunes signaling output and as such it may play a role in the biology of cancer.

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Abbreviations

ECM:

Extracellular matrix

EDMD:

Emery–Dreifuss muscular dystrophy

ER:

Endoplasmic reticulum

HGPS:

Hutchinson–Gilford progeria syndrome

INM:

Inner nuclear membrane

MAPK:

Mitogen activated protein kinase

MSC:

Mesenchymal stem cells

ONM:

Outer nuclear membrane

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Authors and Affiliations

  1. Department of Medicine, College of Physicians and Surgeons, Columbia University, 630W 168th Street P&S 9-435, New York, NY, 10032, USA

    Jason C. Choi & Howard J. Worman

  2. Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, 630W 168th Street P&S 9-508, New York, NY, 10032, USA

    Jason C. Choi & Howard J. Worman

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  1. University of Edinburgh Wellcome Trust Centre for Cell Biology, Edinburgh, United Kingdom

    Eric C. Schirmer

  2. University of Edinburgh Wellcome Trust Centre for Cell Biology, Edinburgh, United Kingdom

    Jose I. de las Heras

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Choi, J.C., Worman, H.J. (2014). Nuclear Envelope Regulation of Signaling Cascades. In: Schirmer, E., de las Heras, J. (eds) Cancer Biology and the Nuclear Envelope. Advances in Experimental Medicine and Biology, vol 773. Springer, New York, NY. https://doi.org/10.1007/978-1-4899-8032-8_9

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