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Translational Neuroscience

Fundamental Approaches for Neurological Disorders

  • Offers a far-reaching and insightful series of perspectives on the effort to bring potentially revolutionary new classes of therapies to the clinic

  • Provides neuroscientists, translational neuroscientists and clinicians a perspective on the nature and promise of translational therapies in the current era

  • Features a wide-ranging yet detailed sample of progress made in the treatment of heretofore untreatable nervous system disorders

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Table of contents (30 chapters)

  1. Front Matter

    Pages i-xv
  2. Introduction

    • Mark H. Tuszynski
    Pages 1-6
  3. Molecular Approaches

    1. Front Matter

      Pages 7-7
    2. Gene Therapy of CNS Disorders Using Recombinant AAV Vectors

      • Giridhar Murlidharan, R. Jude Samulski, Aravind Asokan
      Pages 9-32
    3. NGF and BDNF Gene Therapy for Alzheimer’s Disease

      • Mark H. Tuszynski, Alan H. Nagahara
      Pages 33-64
    4. GDNF and AADC Gene Therapy for Parkinson’s Disease

      • Krystof Bankiewicz, Waldy San Sebastian, Lluis Samaranch, John Forsayeth
      Pages 65-88
    5. GAD Gene Therapy for Parkinson’s Disease

      • Michael G. Kaplitt, Matthew J. During
      Pages 89-98
    6. Antisense Oligonucleotides for Amyotrophic Lateral Sclerosis

      • Wade K. Self, Timothy M. Miller
      Pages 99-109
    7. Gene Therapy for Inborn Errors of Metabolism: Batten Disease

      • Dolan Sondhi, Ronald G. Crystal, Stephen M. Kaminsky
      Pages 111-129
    8. Gene Therapy for Spinal Cord Injury

      • Ioana Goganau, Armin Blesch
      Pages 131-153
    9. Gene Therapy for Epilepsy

      • Thomas J. McCown
      Pages 155-165
    10. Translating Gene Therapy for Pain from Animal Studies to the Clinic

      • Darren Wolfe, David Krisky, James Goss, James Wechuck, Marina Mata, David J. Fink
      Pages 167-183
  4. Cellular Approaches

    1. Front Matter

      Pages 185-185
    2. Stem Cells for Parkinson’s Disease

      • Andrés M. Bratt-Leal, Jeanne F. Loring
      Pages 187-201
    3. Could Stem Cells Be Used to Treat or Model Alzheimer’s Disease?

      • Edsel M. Abud, Mathew Blurton-Jones
      Pages 203-225
    4. Stem Cells for Amyotrophic Lateral Sclerosis

      • Anthony Donsante, Lindsey Nicole Urquia, Nicholas M. Boulis
      Pages 227-258
    5. Stem Cells for Multiple Sclerosis

      • Pamela Sarkar, Neil Scolding
      Pages 259-273
    6. Cell Therapy for Pediatric Disorders of Glia

      • M. Joana Osorio, Steven A. Goldman
      Pages 275-296
    7. Neural Stem Cells for Spinal Cord Injury

      • Paul Lu, Ruhel Ahmad, Mark H. Tuszynski
      Pages 297-315

About this book

Translational Neuroscience offers a far-reaching and insightful series of perspectives on the effort to bring potentially revolutionary new classes of therapies to the clinic, thereby transforming the treatment of human nervous system disorders. Great advances in the fields of basic neuroscience, molecular biology, genomics, gene therapy, cell therapy, stem cell biology, information technology, neuro devices, rehabilitation and others over the last 20 years have generated unprecedented opportunities to treat heretofore untreatable disorders of the nervous system. This book provides a wide-ranging yet detailed sample of many of these efforts, together with the methods for pursuing clinical translation and assessing clinical outcomes. Among the topics covered are Alzheimer’s disease, Parkinson’s disease, stroke, multiple sclerosis, epilepsy, motor neuron disease, pain, inborn errors of metabolism, brain tumors, spinal cord injury, neuroprosthetics, rehabilitation and clinical trial design/consideration.

Translational Neuroscience is aimed at basic neuroscientists, translational neuroscientists and clinicians who seek to gain a perspective on the nature and promise of translational therapies in the current era. Both students and established professionals will benefit from the content.

Editors and Affiliations

  • UnivofCA-SanDiego,VeteransAdmintnMedCntr, Translational Neuroscience Institute, La Jolla, USA

    Mark H. Tuszynski

About the editor

Mark H. Tuszynski, MD, PhD, is a professor of neurosciences and founding director of the Translational Neuroscience Institute at the University of California – San Diego, and a neurologist at the Veterans Administration Medical Center in La Jolla, California. He received his undergraduate and MD degrees from the University of Minnesota in Minneapolis, completed neurology residency at Cornell University Medical Center / The New York Hospital, and subsequently received a PhD in neuroscience from the University of California – San Diego.  Dr. Tuszynski studies basic and translational aspects of neurodegenerative disorders and neurotrauma, and the biological basis of learning and memory.

Bibliographic Information

  • Book Title: Translational Neuroscience

  • Book Subtitle: Fundamental Approaches for Neurological Disorders

  • Editors: Mark H. Tuszynski

  • DOI: https://doi.org/10.1007/978-1-4899-7654-3

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Science+Business Media New York 2016

  • Hardcover ISBN: 978-1-4899-7652-9Published: 09 March 2016

  • Softcover ISBN: 978-1-4939-7942-4Published: 08 April 2018

  • eBook ISBN: 978-1-4899-7654-3Published: 08 March 2016

  • Edition Number: 1

  • Number of Pages: XV, 584

  • Number of Illustrations: 13 b/w illustrations, 85 illustrations in colour

  • Topics: Neurosciences, Neurology, Neurobiology

Buy it now

Buying options

eBook USD 189.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 249.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 249.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access