Abstract
The ability for neuroimaging to now explore brain structure and functioning variations has opened new avenues of research in gender differences (Cairns, Malone, Johnston, & Cammock, Personality and Individual Differences, 6, 653–654, 1985; Gur et al., Science, 267(5197), 528–531, 1995; Kulynych, Vladar, Jones, & Weinberger, Cerebral Cortex, 4(2), 107–118, 1994; Schlaepfer et al., Psychiatry Research: Neuroimaging, 61, 129–135, 1995; Witelson & McCulloch, Schizophrenia Bulletin, 17(4), 583–591, 1991). The first studies emphasized different diseases with less emphasis on gender. Most studies utilized males because females were excluded due to concerns about pregnancy issues (Witelson & McCulloch, Schizophrenia Bulletin, 17(4), 583–591, 1991). The focus of this chapter is on men and neuroimaging findings in various disorders as well as in general development.
Magnetic resonance imaging (MRI) and fMRI (functional MRI) require no radiation. These noninvasive and safe technologies have increased interest in gender differences in brain structure and function. The aim of this chapter is to discuss the extant literature in imaging in men. Gender differences will be briefly discussed as far as what variations may be seen in normal development, as well as in common developmental disorders such as learning disabilities and attention deficit hyperactivity disorder. Where possible, we will follow those differences into adulthood, both for normal development and for those seen in specific disorders in order to more fully understand how normal as well as disrupted development can influence later functioning. As it is not possible within this chapter to discuss the neuroimaging findings in all disorders, we are focusing on findings in men in the disorders of schizophrenia, depression, antisocial personality disorder (ASPD), and stroke/heart attack. This chapter begins with a brief discussion of neuroimaging techniques as well as methodological issues that impact our understanding of the existing research in these areas.
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Alivisatos, B., & Petrides, M. (1997). Functional activation of the human brain during mental rotation. Neuropsychologia, 35(2), 111–118.
Altarelli, I., Leroy, F., Monzalvo, K., Fluss, J., Billard, C., Dehaene-Lambertz, G., … Ramus, F. (in press). Planum temporale asymmetry in developmental dyslexia: Revisiting an old question. Human Brain Mapping.
Armstrong, E., Schleicher, A., Omran, H., Curtis, M., & Zilles, K. (1995). The ontogeny of human gyrification. Cerebral Cortex, 5, 56–63.
Baron-Cohen, S., Ring, H., Chitnis, X., Wheelwright, S., Gregory, L., Williams, S., … Bullmore, E. (2006). fMRI of parents of children with Asperger Syndrome: A pilot study. Brain and Cognition, 61, 122–130.
Borod, J. C., Koff, E., Lorch, M. P., & Nicholas, M. (1986). The expression and perception of facial emotion in brain-damaged patients. Neuropsychologia, 24(2), 169–180.
Cairns, U., Malone, S., Johnston, J., & Cammock, T. (1985). Sex differences in children’s group embedded Figures Test performance. Personality and Individual Differences, 6, 653–654.
Castellanos, F. X., Giedd, J. N., Marsh, S. D., Hamburger, S. D., Vaituzis, A. C., Dickstein, D. P., … Rapoport, J. L. (1996). Quantitative brain magnetic resonance imaging in attention-deficit hyperactivity disorder. Archives of General Psychiatry, 53(7), 607–616.
Caviness, V. S., Kennedy, D. N., Bates, J. F., & Makris, N. (1996). The developing human brain: A morphometric profile. In R. W. Thatcher, G. Reid Lyon, J. Rumsey, & N. A. Krasnegor (Eds.), Developmental neuroimaging: Mapping the development of brain and behavior (pp. 3–14). New York, NY: Academic Press.
Clark, A. S., Maclusky, N. J., & Goldman-Rakic, P. S. (1988). Androgen binding and metabolism in the cerebral cortex of the developing rhesus monkey. Endocrinology, 123, 932–940.
Cohen-Bendahan, C. C., Buitelaar, J. K., van Goozen, S. H. M., & Cohen-Kettenis, P. T. (2004). Prenatal exposure to testosterone and functional cerebral lateralization: A study in same-sex and opposite-sex twin girls. Psychoneuroendocrinology, 29, 911–916.
Cowell, P. E., Turetsky, B. I., Gur, R. C., Grossman, R. I., Shtasel, D. L., & Gur, R. E. (1994). Sex differences in aging of the human frontal and temporal lobes. The Journal of Neuroscience, 14(8), 4748–4755.
Davatzikos, C., & Resnick, S. M. (1998). Sex differences in anotomic measures of interhemispheric connectivity: Correlations with cognition in women but not men. Cerebral Cortex, 8, 635–640.
de la Torre, J. (Ed.). (1997). Cerebrovascular pathology in Alzheimer’s disease. New York, NY: New York Academy of Sciences.
DeCarli, C. (2003). Defining mild cognitive impairment: Prevalence, prognosis, etiology, and treatment. Lancet Neurology, 2, 15–21.
DeCarli, C., Massaro, J., Harvey, D., Hald, J., Tullberg, M., Au, R., … Wolf, P. A. (2005). Measures of brain morphology and infarction in the Framingham heart study: Establishing what is normal. Neurobiology of Aging, 26, 491–510.
Dekaban, A. S., & Sadowsky, D. (1978). Changes in brain weights during the span of human life: Relation of brain weights to body heights and body weights. Annals of Neurology, 4, 345–356.
Doyle-Thomas, K. A., Card, D., Soorya, L. V., Wang, A. T., Fan, J., & Anagnostou, E. (2014). Metabolic mapping of deep brain structures and associations with symptomatology in autism spectrum disorders. Research in Autism Spectrum Disorders, 8(1), 44–51.
Eberling, J. L., Wu, C., Haan, M. N., Mungas, D., Buonocore, M., & Jagust, W. J. (2003). Preliminary evidence that estrogen protects against age-related hippocampal atrophy. Neurobiology of Aging, 24, 725–732.
Filipek, P. A., & Blickman, J. G. (1992). Neurodiagnostic laboratory procedures: Neuroimaging techniques. In R. B. David (Ed.), Pediatric neurology for the clinician (pp. 33–56). Norwalk, CT: Appleton-Lang.
Filipek, P. A., Kennedy, D. N., & Caviness, V. (1992). Neuroimaging in child neuropsychology. In I. Rapin & S. J. Segalowitz (Eds.), Handbook of neuropsychology (Vol. 6, pp. 301–329). New York, NY: Elsevier Science.
Filipek, P. A., Semrud-Clikeman, M., Steingard, R. J., Renshaw, P. F., Kennedy, D. N., & Biederman, J. (1997). Volumetric MRI analysis comparing subjects having attention-deficit hyperactivity disorder with normal controls. Neurology, 48(3,Pt1), 589–601.
Frederikse, M. E., Lu, A., Aylward, E., Barta, P., & Pearlson, G. (1999). Sex differences in the inferior parietal lobule. Cerebral Cortex, 9, 896–901.
Giedd, J. N., Blumenthal, J. D., Jeffries, N. O., Rajapakse, J. C., Vaituzis, A. C., Liu, H., … Castellanos, F. X. (1999). Development of the human corpus callosum during childhood and adolescence: A longitudinal MRI study. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 23, 571–588.
Giedd, J. N., Castellanos, F. X., Rajapakse, J. C., Vaituzis, A. C., & Rapoport, J. L. (1997). Sexual dimorphism of the developing human brain. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 21, 1185–1201.
Giedd, J. N., Rosenthal, M. A., Rose, A. B., Blumenthal, J. D., Molloy, E., Dopp, R. R., … Gogtay, N. (2004). Brain development in healthy children and adolescents: Magnetic resonance imaging studies. In M. S. Keshavan (Ed.), Neurodevelopment and Schizophrenia (pp. 35–43). Cambridge, UK: Cambridge University Press.
Giedd, J. N., Snell, J. W., Lange, N., Rajapakse, J. C., Casey, B. J., Kozuch, P. L., … Rapoport, J. L. (1996). Quantitative magnetic resonance imaging of human brain development: Ages 4-18. Cerebral Cortex, 6, 551–560.
Goldstein, J. M., Seidman, L. J., Horton, N. J., Makris, N., Kennedy, D. N., Caviness, V. S., Jr., & Tsuang, M. T. (2001). Normal sexual dimorphism of the adult human brain assessed by in vivo magnetic resonance imaging. Cerebral Cortex, 11(6), 490–497.
Gur, R. C., Gunning-Dixon, F., Bilker, W. B., & Gur, R. E. (2002). Sex differences in temporo-limbic and frontal brain volumes of healthy adults. Cerebral Cortex, 12, 998–1003.
Gur, R. C., Mozley, L. H., Mozley, P. D., Resnick, S. M., Karp, J. S., Alavi, A., … Gur, R. E. (1995). Sex differences in regional cerebral glucose metabolism during a resting state. Science, 267(5197), 528–531.
Gur, R. C., Mozley, P. D., Resnick, S. M., Gottlieb, G. L., Kohn, M., Zimmerman, R., … Berretta, D. (1991). Gender differences in age effect on brain atrophy measured by magnetic resonance imaging. Proceedings of the National Academy of Sciences, 88(7), 2845–2849.
Gur, R. C., Skolnick, B. E., & Gur, R. E. (1994). Effects of emotional discrimination tasks on cerebral blood flow: Regional activation and its relation to performance. Brain and Cognition, 25(2), 271–286.
Hatazawa, J., Brooks, R. A., Di Chiro, G., & Campbell, G. (1987). Global cerebral glucose utilization is independent of brain size: A PET study. Journal of Computer Assisted Tomography, 11, 571–576.
Holland, D., Chang, L., Ernst, T. M., Curran, M., Buchthal, S. D., Alicata, D., … Dale, A. M. (in press). Structural growth trajectories and rates of change in the first 3 months of infant brain development. JAMA Neurology.
Hubl, D., Koenig, T., Strik, W., Federspiel, A., Kreis, R., Boesch, C., … Dierks, T. (2004). Pathways that make voices: White matter changes in auditory hallucinations. Archives of General Psychiatry, 61, 658–668.
Huttenlocher, P. R. (1990). Morphometric study of human cerebral cortex development. Neuropsychologia, 28, 517–527.
Hynd, G. W., & Semrud-Clikeman, M. (1989). Dyslexia and brain morphology. Psychological Bulletin, 106(3), 447–482.
Jack, C. R., Jr., Dickson, D. W., Parisi, J. E., Xu, Y. C., Cha, R. H., O’Brien, P. C., … Peterson, R. C. (2002). Antemortem MRI findings correlate with hippocampal neuropathology in typical aging and dementia. Neurology, 58, 750–757.
Jernigan, T. L., Trauner, D. A., Hesselink, J. R., & Tallal, P. A. (1991). Maturation of human cerebrum observed in vivo during adolescence. Brain, 114, 2037–2049.
Jonides, J., Smith, E. E., Koeppe, R. A., & Awh, E. (1993). Spatial working memory in humans as revealed by PET. Nature, 363(6430), 623–625.
Kallai, J., Csatho, A., Kover, F., Makany, T., Nemes, J., Horvath, K., … Nagy, F. (2005). MRI-assessed volume of the left and right hippocampi in females correlates with the relative length of the second and fourth fingers (the 2D:4D ratio). Psychiatry Research: Neuroimaging, 140, 199–210.
Kelley, D. B. (1993). Androgens and brain development: Possible contributions to developmental dyslexia. In A. M. Galaburda (Ed.), Dyslexia and development: Neurobiological aspects of extra-ordinary brains (pp. 21–41). Cambridge, MA: Harvard University Press.
Kulynych, J. J., Vladar, K., Jones, D. W., & Weinberger, D. R. (1994). Gender differences in the normal lateralization of the supratemporal cortex: MRI surface-rendering morphometry of Heschl’s gyrus and the planum temporale. Cerebral Cortex, 4(2), 107–118.
Luna, B., & Sweeney, J. A. (2004). Cognitive development: Functional magnetic resonance imaging studies. In M. S. Keshavan (Ed.), Neurodevelopment and schizophrenia (pp. 45–68). Cambridge, UK: Cambridge University Press.
Manning, J. T. (2002). Digit ratio: A pointer to fertility, behavior, and health. New Brunswick, NJ: Rutgers University Press.
Maquet, P., Lejeune, H., Pouthas, V., Bonnet, M., Casini, L., Macar, F., … Comar, D. (1996). Brain activation induced by estimation of duration: A PET study. NeuroImage, 3, 119–126.
McEwen, B. S. (1983). Gonadal steroid influences on brain development and sexual differentiation. In R. Greep (Ed.), Reproductive physiology (pp. 99–145). Baltimore, MD: University Park.
Mesulam, M. M. (1998). From sensation to cognition. Brain: A Journal of Neurology, 121(6), 1013–1052.
Moffat, S. D., Szekely, C. A., Zonderman, A. B., Kabani, N. J., & Resnick, S. M. (2000). Longitudinal change in hippocampal volume as a function of apolipoprotein E genotype. Neurology, 55, 134–136.
Murphy, D. G., DeCarli, C., Daly, E., Haxby, J. V., Allen, G., White, B. J., & Schapiro, M. B. (1993). X-chromosome effects on female brain: A magnetic resonance imaging study of Turner’s syndrome. Lancet, 342, 1197–1200.
Nopoulos, P., Flaum, M., O’Leary, D., & Andreasen, N. C. (2000). Sexual dimorphism in the human brain: Evaluation of tissue volume, tissue composition and surface anatomy using magnetic resonance imaging. Psychiatry Research: Neuroimaging, 98, 1–13.
O’Keefe, J. A., Pedersen, E. B., Castro, J. A., & Handa, R. J. (1993). The ontogeny of estrogen receptors in heterochronic hippocampal and neocortical transplants an intrinsic developmental program. Brain Research: Developmental Brain Research, 75, 105–112.
Pfefferbaum, A., Mathalon, D. H., Sullivan, E. V., Rawles, J. M., Zipursky, R. B., & Lim, K. O. (1994). A quantitative magnetic resonance imaging study of changes in brain morphology from infancy to late adulthood. Archives of Neurology, 51, 874–887.
Raine, A., Lencz, T., Bihrle, S., LaCasse, L., & Colletti, P. (2000). Reduced prefrontal gray matter volume and reduced autonomic activity in antisocial personality disorder. Archives of General Psychiatry, 57(2), 119–127.
Raz, N., Lindenberger, U., Rodrigue, K. M., Kennedy, K. M., Head, D., Williamson, A., & Acker, J. D. (2005). Regional brain changes in aging healthy adults: General trends, individual differences and modifiers. Cerebral Cortex, 15, 1676–1689.
Reiss, A. L., Abrams, M. T., Singer, H. S., Ross, J. L., & Denckla, M. B. (1996). Brain development, gender and IQ in children. A volumetric imaging study. Brain, 119(Pt 5), 1763–1774.
Remage-Healey, L. (in press). Frank Beach Award winner: Steroids as neuromodulators of brain circuits and behavior. Hormones and Behavior.
Rose, A. B., Merke, D. P., Clasen, L. S., Rosenthal, M. A., Wallace, G. L., Vaituzis, A. C., … Giedd, J. N. (2004). Effects of hormones and sex chromosomes on stress-influenced regions of the developing pediatric brain. Annals of the New York Academy of Sciences, 1032, 231–233.
Salat, D., Ward, A., Kaye, J. A., & Janowsky, J. S. (1997). Sex differences in the corpus callosum with aging. Neurobiology of Aging, 18(2), 191–197.
Schlaepfer, T. E., Harris, G. J., Tien, A. Y., Peng, L., Lee, S., & Pearlson, G. D. (1995). Structural differences in the cerebral cortex of healthy female and male subjects: An MRI study. Psychiatry Research: Neuroimaging, 61, 129–135.
Semrud-Clikeman, M., & Fine, J. G. (2009). Neuroimaging in women. In E. Fletcher-Janzen & C. R. Reynolds (Eds.), The neuropsychology of women (pp. 31–67). New York, NY: Kluwer.
Semrud-Clikeman, M., Fine, J. G., Bledsoe, J., & Zhu, D. C. (2012). Gender difference in brain activation on a mental rotation task. International Journal of Neuroscience, 122, 590–597.
Semrud-Clikeman, M., Fine, J. G., & Zhu, D. C. (2011). The role of the right hemisphere for processing of social interactions in normal adults using functional magnetic resonance imaging. Neuropsychobiology, 64, 47–51.
Semrud-Clikeman, M., & Pliszka, S. R. (2006). Correction: Volumetric MRI differences in treatment-naïve vs chronically treated children with ADHD. Neurology, 67(11), 2091.
Shaywitz, B. A., Shaywitz, S. E., Pugh, K. R., Constable, R. T., Skudlarski, P., Fulbright, R. B., … Gore, J. C. (1995). Sex differences in the functional organization of the brain for language. Nature, 373, 607–609.
Sholl, S. A., & Kim, K. L. (1989). Estrogen receptors in the rhesus monkey brain during fetal development. Developmental Brain Research, 50(2), 189–196.
Sowell, E. R., Trauner, D. A., Gamst, A., & Jernigan, T. L. (2002). Development of cortical and subcortical brain structures in childhood and adolescence: A structural MRI study. Developmental Medicine & Child Neurology, 44, 4–16.
Voyer, D., Butler, T., Cordero, J., Brake, B., Silbersweig, D., Stern, E., & Imperato-McGinley, J. (2006). The relation between computerized and paper-and-pencil mental rotation tasks: A validation study. Journal of Clinical and Experimental Neuropsychology, 28, 928–939.
Wang, S., & Young, K. M. (in press). White matter plasticity in adulthood. Neuroscience.
Wendt, P. E., & Risberg, J. (1994). Cortical activation during visual spatial processing: Relation between hemispheric asymmetry of blood flow and performance. Brain and Cognition, 24(1), 87–103.
Winstein, C. J., Grafton, S. T., & Pohl, P. S. (1997). Motor task difficulty and brain activity: Investigation of goal-directed reciprocal aiming using positron emission tomography. Journal of Neurophysiology, 77(3), 1581–1594.
Witelson, S. F. (1989). Hand and sex differences in the isthmus and genu of the human corpus callosum. Brain, 112, 799–835.
Witelson, S. F., Glezer, I. I., & Kigar, D. L. (1995). Women have greater density of neurons in posterior temporal cortex. Journal of Neuroscience, 15(5), 3418–3428.
Witelson, S. F., & Kigar, D. L. (1988a). Anatomical development of the corpus callosum in humans: A review with reference to sex and cognition. In D. L. Molfese & S. J. Segalowitz (Eds.), Brain lateralization in children (pp. 35–57). New York, NY: Guilford Press.
Witelson, S. F., & Kigar, D. L. (1988b). Aysmmetry in brain function follows asymmetry in anatomical form: Gross, microscope, postmortem and imaging studies. In F. Boller & J. Grafman (Eds.), Handbook of neuropsychology (Vol. 1, pp. 111–142). Amsterdam, The Netherlands: Elsevier Science Publishers.
Witelson, S. F., & Kigar, D. L. (2004). Sylvian fissure morphology and asymmetry in men and women: Bilateral differences in relation to handedness in men. Journal of Comparative Neurology, 323(3), 326–340.
Witelson, S. F., & McCulloch, P. B. (1991). Premortem and postmortem measurement to study structure with function: A human brain collection. Schizophrenia Bulletin, 17(4), 583–591.
Witelson, S. F., & Pallie, W. (1973). Left hemisphere specialization for language in the newborn: Neuroanatomical evidence of asymmetry. Brain, 96, 641–646.
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Semrud-Clikeman, M., Robillard, R. (2015). Imaging and Development: Relevant Findings in Males. In: Zaroff, C., D'Amato, R. (eds) The Neuropsychology of Men. Issues of Diversity in Clinical Neuropsychology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-7615-4_2
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