Skip to main content
SpringerLink
Log in

Comments on Some Present and Future Problems in Protein Structure

  • Chapter
Neutrons in Biology

Part of the book series: Basic Life Sciences ((BLSC,volume 27))

Abstract

In 1964 some program officers at NIH were seriously, and understandably, concerned that the solution of the myoglobin structure might have been an accident. The intense effort that had been going on in the field of protein crystallography during the previous five years had not produced any additional structures and perhaps would not in the foreseeable future. The dramatic appearance of the lysozyme model in 1965 fortunately put an end to thoughts of major funding shifts that were being discussed. Let us hope some comparable event occurs this year.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bradbury, M., in: “Mobility and Function in Proteins and Nucleic Acids,” Ciba Symp. 93:246–65 (1983).

    CAS  Google Scholar 

  2. Careri, G., Gratton, E., Yang, P.H., and Rupley, J.A., Nature 284:572–3 (1980).

    Article  PubMed  CAS  Google Scholar 

  3. Chotia, C., Nature 254:304–8 (1975).

    Article  Google Scholar 

  4. Eden, D., Matthew, J.B., Rosa, J.J., and Richards, F.M., Proc. Natl. Acad. Sci. USA 79:815–19 (1982).

    Article  PubMed  CAS  Google Scholar 

  5. Edsall, J.T. and MacKenzie, H.A., Adv. Biophys. 10:137–207 (1978).

    PubMed  CAS  Google Scholar 

  6. Edsall, J.T. and MacKenzie, H.A., Adv. Biophys., in press (1982).

    Google Scholar 

  7. Fink, A.L., Trends Biochem. Sci. 4:8–10 (1979).

    Article  CAS  Google Scholar 

  8. Finney, J.L., Goodfellow, J.M., and Pool, P.L., in: “Structural Molecular Biology: Methods and Applications,” D.B. Dawer et al., eds., Plenum, New York, in press (1982).

    Google Scholar 

  9. Frauenfelder, H., Petsko, G.A., and Tsernoglou, D., Nature 280:558–63 (1979).

    Article  PubMed  CAS  Google Scholar 

  10. Holmes, K.C., J. Supramol. Struct. 12:305–20 (1979).

    Article  PubMed  CAS  Google Scholar 

  11. Karplus, M. and McCammon, J.A., Nature 277:578 (1979).

    Article  PubMed  CAS  Google Scholar 

  12. Kauzmann, W., Adv. Protein Chem. 14:1–64 (1959).

    Article  PubMed  CAS  Google Scholar 

  13. Lee, B. and Richards, F.M., J. Mol. Biol. 55:379–400 (1971).

    Article  PubMed  CAS  Google Scholar 

  14. LeMaster, D.M. and Cronan, J.E., J. Biol. Chem. 257:1224–30 (1982).

    PubMed  CAS  Google Scholar 

  15. LeMaster, D.M. and Richards, F.M., J. Labeled Comp. Radiopharm. 19: 639–46 (1982).

    Article  CAS  Google Scholar 

  16. LeMaster, D.M. and Richards, F.M., Ann. Biochem. 122:223–37 and 238-47 (1982).

    Article  CAS  Google Scholar 

  17. Matthew, J.B., Shire, S.J., March, K.L., Flanagan, M.A., and Gurd, F.R.N., Crit. Rev. Chem., in preparation (1982).

    Google Scholar 

  18. McCammon, J.A. and Karplus, M., Annu. Rev. Phys. Chem. 31:29–45 (1980).

    Article  CAS  Google Scholar 

  19. Northrup, S.H., Pear, M.R., McCammon, J.A., Karplus, M., and Takano, T., Nature 287:659–60 (1980).

    Article  PubMed  CAS  Google Scholar 

  20. Petsko, G.A., Biochemistry, in press (1982).

    Google Scholar 

  21. Reid, B.R. and Hare, D.R., in: “Mobility and Function in Proteins and Nucleic Acids,” Ciba Symp. 93:208–20 (1983).

    CAS  Google Scholar 

  22. Richards, F.M., Annu. Rev. Biophys. Bioeng. 6:151–76 (1977).

    Article  PubMed  CAS  Google Scholar 

  23. Richardson, J., Adv. Protein Chem. 34:168–340 (1981).

    Google Scholar 

  24. Roberts, G.C.K., Duckworth, H.W., Packman, L.C., and Perham, R.N., in: “Mobility and Function in Proteins and Nucleic Acids,” Ciba Symp. 93:47–62 (1983).

    CAS  Google Scholar 

  25. Rogers, N.K. and Steinberg, M.J.E., Peptides and Proteins 14, in press.

    Google Scholar 

  26. Rosa, J. and Richards, F.M., J. Mol. Biol. 145:835–51 (1981).

    Article  PubMed  CAS  Google Scholar 

  27. Rossmann, M.G. and Argos, P., Annu. Rev. Biochem. 50:497–532 (1981).

    Article  PubMed  CAS  Google Scholar 

  28. Rupley, J.A., Yang, P.H., and Tollin, G., in: “Water in Polymers,” S.P. Rowland, ed., Am. Chem. Soc. Symp. Ser. No. 127, pp. 111-32 (1980).

    Google Scholar 

  29. Salemme, F.R., Nature, in press (1982).

    Google Scholar 

  30. Thomas, K.A. and Schechter, A.N., in: “Biological Regulation and Development,” R.F. Goldberger, ed., Vol. 2, pp. 43–100, Plenum, New York (1980).

    Chapter  Google Scholar 

  31. Turro, N.J., Ann. NY Acad. Sci. 346:1–17 (1980).

    Article  CAS  Google Scholar 

  32. Wedin, R.E., Delepierre, M., Dobson, C.M., and Poulsen, F.M., Biochemistry 21:1098–1103 (1982).

    Article  PubMed  CAS  Google Scholar 

  33. Wuthrich, K. and Wagner, G., J. Mol. Biol. 130:1–18 (1979).

    Article  PubMed  CAS  Google Scholar 

  34. Wuthrich, K., Wider, G., Wagner, G., and Braun, W., J. Mol. Biol. 155:311 (1982).

    Article  PubMed  CAS  Google Scholar 

  35. Bernstein, F.C., Koetzle, T.F., William, G.J.B., Meyer, E.F., Brice, M.D., Rodgers, J.R., Kennard, O., Shimanouchi, T., and Tasmuni, M., J. Mol. Biol. 112:535–42 (1977).

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, 06511, USA

    Frederic M. Richards

Authors
  1. Frederic M. Richards
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Brookhaven National Laboratory, Associated Universities, Inc., Upton, New York, USA

    Benno P. Schoenborn

Rights and permissions

Reprints and permissions

Copyright information

© 1984 Springer Science+Business Media New York

About this chapter

Cite this chapter

Richards, F.M. (1984). Comments on Some Present and Future Problems in Protein Structure. In: Schoenborn, B.P. (eds) Neutrons in Biology. Basic Life Sciences, vol 27. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0375-4_1

Download citation

  • DOI: https://doi.org/10.1007/978-1-4899-0375-4_1

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-0377-8

  • Online ISBN: 978-1-4899-0375-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation