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Inhibitors of Arachidonate Metabolism and Effects on PAF Production

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Platelet-Activating Factor and Related Lipid Mediators 2

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 416))

Abstract

Our understanding of the enzyme Coenzyme A-independent transacylase (CoA-IT) has increased dramatically over the last 10 years. The enzyme catalyses the removal of the fatty acyl group from the sn-2 position of glycerophospholipids (GPL) and transfers it into 1-radyl-2-lyso GPL.1 The enzyme shows striking selectivity for transfer of arachidonate and other long-chain, unsaturated fatty acyl groups. It also shows strong preference for phosphocholine-and phosphoethanolamine-containing GPL, along with a preference for using 1-ether GPL as acceptors for the transferred arachidonate.2 The mechanism of action of CoA-IT has yet to be defined at the molecular level, but CoA-IT is hypothesized to be a member of the family of tranferases typified by lecithin-cholesterol acyl transferase.3 Based on these characteristics, CoA-IT has been presumed to play a role in the movement of arachidonate between GPL that occurs in inflammatory cells.4–7

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References

  1. Kramer, R. M. and Deykin, D. (1983) J. Biol. Chem. 258, 1380E - 13811

    Google Scholar 

  2. Sugiura, T., Masuzawa, Y., Nakagawa, Y., and Waku, K. (1987) J. Biol. Chem. 262, 1199–1205

    PubMed  CAS  Google Scholar 

  3. Winkler, J. D. and Chilton, F. H. (1993) Drug News Perspec. 6, 133–138

    Google Scholar 

  4. MacDonald, J. I. S. and Sprecher, H. (1991) Biochim. Biophys. Acta 1084, 105–121

    Article  PubMed  CAS  Google Scholar 

  5. Snyder, F., Lee, T. -C., and Blank, M. L. (1992) Prog. Lipid Res. 31, 65–86

    Article  PubMed  CAS  Google Scholar 

  6. Winkler, J. D. and Chilton, F. H. (1995) in Inflammation: Mediators and Pathways (Ruffolo, R. and Hollinger, J., eds) pp. 147–171, CRC Press, Inc., Boca Raton, FL

    Google Scholar 

  7. Chilton, F. H., Fonteh, A. N., Surette, M. E., Triggiani, M., and Winkler, J. D. (1995) Biochim. Biophys. Acta (in press)

    Google Scholar 

  8. Suga, K., Kawasaki, T., Blank, M. L., and Snyder, F. (1990) J. Biol. Chem. 265, 12363–12371

    PubMed  CAS  Google Scholar 

  9. Sugiura, T., Fukuda, T., Masuzawa, Y., and Waku, K. (1990) Biochim. Biophys. Acta Lipids Lipid Metab. 1047, 223–232

    Article  CAS  Google Scholar 

  10. Winkler, J. D., Sung, C. -M., Hubbard, W. C., and Chilton, F. H. (1992) Biochem. Pharmacol. 44, 2055–2066

    Article  PubMed  CAS  Google Scholar 

  11. Chilton, F. H., Fonteh, A. N., Sung, C. -M., Hickey, D. M. B., Torphy, T. J., Mayer, R. J., Marshall, L. A., Heravi, J. D., and Winkler, J. D. (1995) Biochemistry 34, 5403–5410

    Article  PubMed  CAS  Google Scholar 

  12. Winkler, J. D., Fonteh, A. N., Sung, C. -M., Heravi, J. D., Nixon, A. B., Chabot-Fletcher, M., Griswold, D., Marshall, L. A., and Chilton, F. H. (1995) J. Pharmacol. Exp. Thee. (in press)

    Google Scholar 

  13. Triggiani, M., Fonteh, A. N., and Chilton, F. H. (1992) Biochem. J. 286, 497–503

    PubMed  CAS  Google Scholar 

  14. Mueller, H. W., O’Flaherty, J. T., and Wykle, R. L. (1983) J. Biol. Chem. 258, 6213–6218

    PubMed  CAS  Google Scholar 

  15. Winkler, J. D., Sung, C. -M., Hubbard, W. C., and Chilton, F. H. (1993) Biochem. J. 291, 825–831

    PubMed  CAS  Google Scholar 

  16. Takamura, H., Kasai, H., Arita, H., and Kito, M. (1990) J. Lipid Res. 31, 709–717

    PubMed  CAS  Google Scholar 

  17. Marshall, L. A. and Roshak, A. (1993) Biochem. Cell Biol. 71, 331–339

    Article  PubMed  CAS  Google Scholar 

  18. Marshall, L. A., Winkler, J. D., Griswold, D. E., Bolognese, B., Roshak, A., Sung, C. -M., Webb, E. F., and Jacobs, R. (1994) J. Pharmacol. Exp. Ther. 268, 709–717

    PubMed  CAS  Google Scholar 

  19. Marshall, L. A., Hall, R. H., Winkler, J. D., Badger, A., Bolognese, B., Roshak, A., Flamberg, P. L., Sung, C. -M., Chabot-Fletcher, M., Adams, J. L., and Mayer, R. J. (1995) J. Pharmacol. Exp. Thee. (in press)

    Google Scholar 

  20. Street, I. P., Lin, H. -K., Laliberté, F., Ghomashchi, F., Wang, Z., Perrier, H., Tremblay, N. M., Huang, Z., Weech, P. K., and Gelb, M. H. (1993) Biochemistry 32, 5935–5940

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Division of Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania, 19406, USA

    James D. Winkler, Chiu-Mei Sung & Lisa A. Marshall

  2. Section on Pulmonary and Critical Care Medicine and Department of Biochemistry, Bowman Gray School of Medicine, Winston-Salem, North Carolina, 27103, USA

    Floyd H. Chilton

Authors
  1. James D. Winkler
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  2. Chiu-Mei Sung
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  3. Lisa A. Marshall
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  4. Floyd H. Chilton
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Editor information

Editors and Affiliations

  1. Free University Berlin, Berlin, Germany

    Santosh Nigam  & Gert Kunkel  & 

  2. University of Utah, Salt Lake City, Utah, USA

    Stephen M. Prescott

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© 1996 Springer Science+Business Media New York

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Winkler, J.D., Sung, CM., Marshall, L.A., Chilton, F.H. (1996). Inhibitors of Arachidonate Metabolism and Effects on PAF Production. In: Nigam, S., Kunkel, G., Prescott, S.M. (eds) Platelet-Activating Factor and Related Lipid Mediators 2. Advances in Experimental Medicine and Biology, vol 416. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0179-8_3

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  • DOI: https://doi.org/10.1007/978-1-4899-0179-8_3

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-0181-1

  • Online ISBN: 978-1-4899-0179-8

  • eBook Packages: Springer Book Archive

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