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Brain Plasticity pp 137–143Cite as

Regulation by Neurotransmitters of Glial Energy Metabolism

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 429))

Abstract

Astrocytes are ideally positioned to couple neuronal activity with energy metabolism. Thus particular astrocytic profiles, the end-feet, surround intraparenchymal capillaries, implying that they form the first cellular barrier that energy substrates entering the brain parenchyma, in particular glucose, encounter. In addition, astrocytes possess receptors and reuptake sites for neurotransmitters, and astrocytic processes ensheath synaptic contacts: these features imply that astrocytes are ideally positioned to sense increases in synaptic activity and to couple them with energy metabolism. We have characterized three metabolic processes regulated by neurotransmitters in primary astrocyte cultures prepared from neonatal mouse cerebral cortex: glycogenolysis, glycogen resynthesis and glycolysis.

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Author information

Authors and Affiliations

  1. Laboratoire de Recherche Neurologique Institut de Physiologie et Service de Neurologie du CHUV Faculté de Médecine, Université de Lausanne, 7, rue du Bugnon, CH-1005, Lausanne, Switzerland

    Pierre J. Magistretti & Luc Pellerin

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  1. Pierre J. Magistretti
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  2. Luc Pellerin
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Editor information

Editors and Affiliations

  1. University of Torino, Torino, Italy

    Guido Filogamo

  2. University of Colorado Health Sciences Center, Denver, Colorado, USA

    Antonia Vernadakis

  3. University of Cagliari, Cagliari, Italy

    Fulvia Gremo

  4. Université Montpellier II, Montpellier, France

    Alain M. Privat

  5. University of California, Berkeley, California, USA

    Paola S. Timiras

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© 1997 Springer Science+Business Media New York

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Magistretti, P.J., Pellerin, L. (1997). Regulation by Neurotransmitters of Glial Energy Metabolism. In: Filogamo, G., Vernadakis, A., Gremo, F., Privat, A.M., Timiras, P.S. (eds) Brain Plasticity. Advances in Experimental Medicine and Biology, vol 429. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9551-6_10

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  • DOI: https://doi.org/10.1007/978-1-4757-9551-6_10

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-9553-0

  • Online ISBN: 978-1-4757-9551-6

  • eBook Packages: Springer Book Archive

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