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Cytolytic T Lymphocyte Recognition of Subcellular Antigen

  • Chapter
Mechanisms of Cell-Mediated Cytotoxicity

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 146))

Abstract

Specific antigen recognition is required to stimulate generation of a cytolytic T lymphocyte (CTL1) response and to allow the resulting effector CTLs to bind and lyse the target cells. Reliable assays allow in vitro assessment of stimulation of a primary and secondary response and of the effector-target interaction. The antigens required to trigger generation of a response are the same as those required to allow binding and lysis by the effector CTL.

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Author information

Authors and Affiliations

  1. Department of Pathology and the Sidney Farber Cancer Institute, Harvard Medical School, 02115, Boston, Massachusetts, USA

    Matthew F. Mescher, Steven P. Balk, Steven J. Burakoff & Steven H. Herrmann

Authors
  1. Matthew F. Mescher
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  2. Steven P. Balk
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  3. Steven J. Burakoff
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  4. Steven H. Herrmann
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Editor information

Editors and Affiliations

  1. University of California, Los Angeles, California, USA

    William R. Clark

  2. Centre d’lmmunologie, INSERM-CNRS de Marseille-Luminy, Marseille, France

    Pierre Golstein

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© 1982 Plenum Press, New York

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Mescher, M.F., Balk, S.P., Burakoff, S.J., Herrmann, S.H. (1982). Cytolytic T Lymphocyte Recognition of Subcellular Antigen. In: Clark, W.R., Golstein, P. (eds) Mechanisms of Cell-Mediated Cytotoxicity. Advances in Experimental Medicine and Biology, vol 146. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8959-0_3

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  • DOI: https://doi.org/10.1007/978-1-4684-8959-0_3

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-8961-3

  • Online ISBN: 978-1-4684-8959-0

  • eBook Packages: Springer Book Archive

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