Abstract
It is now clear that a broad range of grafting techniques can be used to successfully introduce fetal homografts of the vertebrate spinal cord into an adult injury site (Sladek and Gash, 1984; Houle and Reier, 1988). In general, these grafts are capable of long-term survival, and undergo extensive differentiation even to the extent that many exhibit features characteristic of homologous sites of the normal adult CNS. Furthermore, these grafts can form axonal interactions in varying degrees with the recipient spinal cord; host axons often project to the transplants, and dorsal root afferents penetrate the graft neuropil (Tessler et al., 1988). Thus, fetal spinal grafts also provide an excellent experimental condition in which to investigate problems of development, plasticity, and regeneration (Sladek and Gash, 1984). Although important questions remain about the mechanism by which such repair processes take place, various lines of evidence suggest that this could occur either by restoration of neurotransmitter stores, by provision of a cellular bridge which can facilitate axonal elongation across a lesion, or by anatomical and physiological reconstruction of damaged synaptic circuitries. In this regard, transplantation seems to offer great promise as a possible therapeutic approach to a variety of brain disorders related to disease and trauma.
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References
Bregman, B.S. and Reier, P.J., 1986, Neural tissue transplants rescue axotomized rubrospinal cells from retrograde death. J.Comp.Neurol., 244:86–95.
David, S. and Aguayo, A.J., 1981, Axonal elongation into peripheral nervous system ‘bridges’ after central nervous system injury in adult rats. Science, 214:932.
Erdmann W., 1977, Microelectrode studies in the brain of fetal and newborn rats. Adv.Exp.Med.Biol., 94:455–461.
Ernest, J.T. and Goldstick, T.K., 1984, Retinal oxygen tension and oxygen reactivity in retinopathy of prematurity in kittens. Invest.Ophthalmol.Vis., 25:1129–1134.
Gonya-Mcgee, T. and Stokes, B.T., 1980, Acute modification of embryonic spinal cord activity induced by hypoxia. Dev.Neurosci., 3:11–18.
Hayashi, N., Green, B., Gonzalez-Carvajal, M., Hora, J. and Vera, R., 1983, Local blood flow, oxygen tension, and oxygen consumption in the rat spinal cord, Part 1: oxygen metabolism and neuronal function. J. Neuro surer., 58:516–525.
Houle, J.D. and Reier, P.J., 1988, Transplantation of fetal spinal cord tissue into the chronically injured adult rat spinal cord. J Comp.Neurol., 269:535–547.
Joyner, W.L., Young, R., Blank, D., Eccleston-Joyner, C.A. and Gilmore, J.P., 1988, In vivo microscopy of the cerebral microcirculation using neonatal allografts in hamsters. Circ.Res, 63:758–766.
Knighton, D.R., Silver, I.A. and Hunt, T.K., 1981, Regulation of wound-healing angiogenesis — Effect of oxygen gradients and inspired oxygen concentration. Surgery., 90:262–270.
Krum, J.M. and Rosenstein, J.M., 1988, Patterns of angiogenesis in neural transplant models: II. Fetal neocortical transplants. J Comp.Neurol., 271:331–345.
Lasek, R.J., McQuarrie, I.G. and Wujek, J.R., 1981, The central nervous system regenerative problem: neuron and environment, in: “Post-Traumatic Peripheral Nerve Regeneration,” H. Millesi, S. Mingrino and A. Gorio, ed., Raven Press, New York.
Lawrence, J.M., Huang, S.K. and Raisman, L.G., 1984, Vascular and astrocytic reactions during establishment of hippocampal transplants in adult host brain. Neuroscience, 12:745–760.
Leitch, D.R. and Hallenbeck, J.M., 1985, Oxygen in the treatment of spinal cord decompression sickness. Undersea Biomed.Res., 12:269–289.
Nathaniel, E.J.H. and Nathaniel, D.R., 1981, The reactive astrocyte. Adv.Cell Neurobio., 2:249–301.
Reier, P.J., 1985, Neural tissue grafts and repair of the injured spinal cord. Neuropathol.Appl.Neurobiol., 11:81–104.
Reier, P.J., Bregman, B.S. and Wujek, J.R., 1986, Intraspinal transplantation of fetal spinal cord tissue: An approach toward functional repair of the injured spinal cord, in: “Proceedings of the International Symposium on Plasticity and Development of the Mammalian Spinal Cord,” M. Goldberger, A. Gorio and M. Murray ed.,
Reier, P.J. and Houle, J.D., 1988, The glial scar: its bearing on axonal elongation and transplantation approaches to CNS repair. Adv.Neurol., 47:87–138.
Rosenstein, J.M. and Brightman, M.W., 1983, Circumventing the blood-brain barrier with autonomic ganglion transplants. Science, 221:881–887.
Sladek, J.R. and Gash, D.M., 1984, Morphological and functional properties of transplanted vasopressin neurons, in.: “Neural Transplants: Development and Function,” J. Sladek and D. Gash, ed., Plenum Press, New York.
Stenevi, U., Bjorklund, A. and Svendgaard, N-NA., 1976, Transplantation of central and peripheral monoamine neurons to adult to adult rat brain: techniques and conditions for survival. Brain Res., 114:1–20.
Stokes, B.T., 1982, O2 tension in the spinal cord of the avian embryo. J.Appl.Physiol., 53:1455–1460.
Stokes, B.T., Fox, P. and Hollinden, G., 1985, Extracellular metabolites: their measurement and role in the acute phase of spinal cord injury, in: “Trauma of the Central Nervous System,” R.G. Dacey ed., Raven Press, New York.
Stokes, B.T. and Garwood, M., 1982, Traumatically induced alterations in the oxygen fields in the canine spinal cord. Exp.Neurol., 75:665–677.
Stokes, B.T., Garwood, M. and Walters, P., 1981, Oxygen fields in specific spinal loci of the canine spinal cord. Am.J.Physiol., 240:H761-H766.
Tessler, A., Himes, B.T., Houle, J. and Reier, P.J., 1988, Regeneration of adult dorsal root axons into transplants of embryonic spinal cord. J Comp.Neurol., 270:537–548.
Wixson, S.K., White, W.J., Hughes, H.C., Jr., Lang, C.M. and Marshall, W.K., 1987, The effects of pentobarbital, fentanyl-droperidol, ketamine-xylazine and ketamine-diazepam on arterial blood pH, blood gases, mean arterial blood pressure and heart rate in adult male rats. Lab. Animal Sci., 37:736–742.
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© 1990 Plenum Press, New York
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Stokes, B.T., Reier, P.J. (1990). Spinal Cord Repair: Is Tissue Oxygenation an Important Variable?. In: Piiper, J., Goldstick, T.K., Meyer, M. (eds) Oxygen Transport to Tissue XII. Advances in Experimental Medicine and Biology, vol 277. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8181-5_42
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DOI: https://doi.org/10.1007/978-1-4684-8181-5_42
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