Abstract
The ability of neurons to remodel the extent and configuration of their axons and dendrites plays an important role in maintaining function in the central nervous system in normal aging (Cotman and Anderson, 1983; Coleman and Flood, 1987). Conversely, the lack of an appropriate compensatory response of surviving cells to phenomena in the aged brain such as spontaneous neuron loss, deafferentation, or neurotransmitter deficits, is hypothesized to represent a common pathophysiological process in age-related neurodegenerative disorders (Coleman and Flood, 1986). Although the mechanisms governing synaptic remodelling in the adult brain are unknown, we hypothesize that it involves altered genomic expression in surviving neurons of afferent projection systems, whose terminals are induced to sprout and reinnervate deafferentated tissue (Cotman and Nieto-Sampedro, 1984). Moreover, since astrocytes participate in the process of removing degenerating axons and dendrites following a deafferentation lesion (Gage et al., 1988), alterations in the genomic response of these cells could be a critical factor leading to incomplete or delayed reorganization of new synaptic circuits (Scheff et al., 1989).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Buttyan R., Olsson C.A., Pintar J., Chang C., Bandyk M., NG P.Y., and Sawczuk I.S., 1989, Induction of the TRPM-2 gene in cells undergoing programmed cell death. Mol. and Cell. Biol., 9:3473.
Capetanaki Y.G., Ngai J., and Lazarides E., 1984, Regulation of the expression of genes coding for the intermediate filament subunits vimentin, desmin, and glial fibrillary acidic protein, in: “Molecular Biology of the Cytoskeleton,” Cold Spring Harbor Press.
Chang H.T., Wilson C.J., and Kitai S.T., 1981, Single neostriatal efferent axons in the globus pallidus: a light and electron microscopy study, Science, 213:915.
Cheng H.W., Anavi Y., Goshgarian H., McNeill T.H., and Rafols J.A., 1988, Loss and recovery of striatal dendritic spines following lesions in the cerebral cortex of adult and aged mice, Soc. Neurosci. Abst., 14:1219.
Coleman P.D., and Flood D.G., 1986, Dendritic proliferation in the aging brain as a compensatory repair mechanisms, Prog. Brain Res., 70:227.
Coleman P.D., and Flood D.G., 1987, Neurons numbers and dendritic extent in normal aging and Alzheimer disease, Neurobiol. Aging, 8:521.
Collard M.W., and Griswald M.D., 1987, Biosynthesis and molecular cloning of sulfated glycoprotein 2 secretedby rat Sertoli cells, Biochem., 26:3297.
Cotman C.W., and Nieto-Sampedro M., 1984, Cell biology of Synaptic plasticity. Science. 225:1287.
Cotman C.W., and Anderson K.J., 1983, Synaptic plasticity and functional stabilization in the hippocampal formation: possible role in Alzheimer disease, in: “Advances in Neurology,” S.G. Waxman, ed., Vol. 47 Functional recovery in Neurological Disease, Raven Press, New York, NY.
Duguid J.R., Bohmont C.W., Liu N., and Tourtellotte W., 1989, Changes in brain gene expression shared by scrapie and Alzheimer disease, Proc. Natl. Acad. Sci (USA). 86:7260.
Freund T.F., Powell J.F., and Smith A.D., 1984, Tyrosine hydroxylase immunoreactivity boutons in synaptic contact with identified striatonigral neurons with particular reference to dendritic spines, Neuroscience. 13:1189.
Gage F.H., Olejniczak P., and Armstrong D., 1988, Astrocytes are important for sprouting in the septohippocampal circuit, Exp. Neurol., 102:2.
Geddes S.W., Wong J., Choi B.H., Kim R. C., Cotman C.W., and Miller F.D., 1990, Increased expression of embrionyc growth associated mRNA in Alzheimer disease, Neurosci. Lett., (in press).
Isacson O., Fisher W., Wictorin K., Dawbarn D., and Bjorklund A., 1987, Astroglial response in the excitotoxically lesioned neostriatum and its projections areas in the rat, Neuroscience. 20:1043.
Kalil K., and Skene J.H.P., 1986, Elevated synthesis of an axonally transported protein correlates with axon outgrowth in normal and injured pyramidal tracts, J. Neurosci., 6:2563.
Kosik K.S., D’Orecchio Lisa., Bruns G.A., Benowitz L.I., MacDonald P., Cox D.R., and Neve R., 1988, Human GAP-43: its deduced aminoacid sequence and chromosomal localization in mouse and human, Neuron. 1:127.
Jenne D.E., and Tschopp J., 1989, Molecular structure and functional characterization of a human complement cytolysis inhibitor found in blood and seminal plasma: identity to sulfated glycoprotein 2., a constituent of rat testis fluid, Proc. Natl. Acad. Sci. (USA). 86:7123.
Lozano A.M., Doster S.K., Aguayo A.J., and Willard M.B., 1987, Immunoreactivity to GAP-43 in axotomized and regenerating retinal ganglion cells of adult rats, Abstr. Soc. Neurosci., 13:1389.
May P.C., Lampert-Etchelles M., Johnson S.A., Poirier J., Master J., and Finch C.E., 1990, Dynamics of gene expression for hippocampal glycoprotein elevated in alzheimer’s disease and in response to experimental lesion in rat, Neuron, (in press).
McNeill T.H., Brown S.A., Rafols J.A., and Shoulsson I., 1989, Atrophy of medium spiny I striatal dendrites in advanced Parkinson’s disease, Brain Res., 455:158.
McNeill T.H. and Koeck L.L., 1990, Differential effects of advancing age on neurotransmitter, cell loss in the substantia nigra and striatum of the C57BL/6N mouse, Brain Res., (in press).
Needles D.L., Nieto-Sampedro M., and Cotman C.W., 1986, Induction of a neurite factor in rat brain following injury or deafferentation, Neuroscience. 18:517.
Nichols N.R., Osterburg H.H., Masters J.N., Millar S.L., and Finch S.L., 1990, Messenger RNA for glial fibrillary acidic protein is decreased in rat brain following acute and chronic corticosterone, Mol. Brain Res., 7:1.
Pasinetti G.M., Lerner S.P., Johnson S.A., Morgan D.G., Telford N.A., and Finch C.E.F., 1989, Chronic lesions differentially decrease tyrosine hydroxylase messenger RNA in dopaminergic neurons of substantia nigra, Mol. Brain Res., 5:203.
Poirier J., May P.C., Osterburg H.H., Geddes J., Cotman C., and Finch C.E., 1990, Selective alterations of RNA in rat hippocampus after enthorhinal cortex lesioning, Proc. Natl. Acad. Sci. (USA). 87:303.
Reh T.A., Redshaw J.D., and Bisby M.A., 1987, Axons of the pyramidal tract do not increase their transport of growth-associated proteins after axotomy, Mol. Brain Res., 2:1.
Scheff W.S., and Dkosky S.T., 1989, Glucocorticoid suppression of lesion-induced synaptogenesis: effect of temporal manipulation of steroid treatment, Exp. Neurol., 105:260.
Skene, J.H.P., 1989. Axonal growth-associated proteins, Ann. Rev. Neurosci., 12:127.
Steward O., Torre E.R., Philips L.L., and Trimmer P.A., 1990, The process of reinnervation in the dente gyrus of adult rats: time course of increases in mRNA for glial fibrillary acidic protein, J. Neurosci., 10:2373.
Tsuruta J., Wong K., Fritz B., and Griswold B., 1990, Structural analysis of sulphated glycoprotein 2 from aminoacid sequence, Relationship to clusterin and serum protein 40, 40. Biochem. J., 268:571.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Plenum Press, New York
About this chapter
Cite this chapter
Pasinetti, G.M., Cheng, H.W., Reinhard, J.F., Finch, C.E., McNeill, T.H. (1991). Molecular and Morphological Correlates Following Neuronal Deafferentation: A Cortico-Striatal Model. In: Timiras, P.S., Privat, A., Giacobini, E., Lauder, J., Vernadakis, A. (eds) Plasticity and Regeneration of the Nervous System. Advances in Experimental Medicine and Biology, vol 296. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8047-4_23
Download citation
DOI: https://doi.org/10.1007/978-1-4684-8047-4_23
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-8049-8
Online ISBN: 978-1-4684-8047-4
eBook Packages: Springer Book Archive