Abstract
The biosynthesis of DNA in the eukaryotic system distinguishes itself from that in prokaryotes by many significant points. Although much evidence indicates that in both systems replication proceeds in both directions from the initiation point in the complementary strands (Hubermann and Riggs, 1968; Callan, 1974; Kriegstein and Hogness, 1974; Painter, 1976), the existence of multiple initiation points, the multiple termini, the differences in the size of replication units in different eukaryotic systems, the rate of chain growth, etc., are some of the complex features of eukaryotic systems. The organization of eukaryotic chromatin, the existence of heterochromatin and euchromatin, and the new concept of DNA-histone organization in the nucleo-some (Seale, 1978) demand additional assumptions in establishing the regulatory mechanism of DNA replication in eukaryotes.
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Mukherjee, A.S. et al. (1980). Regulation of DNA Replication in Drosophila . In: Siddiqi, O., Babu, P., Hall, L.M., Hall, J.C. (eds) Development and Neurobiology of Drosophila . Basic Life Sciences, vol 16. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7968-3_6
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