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The Lipoxin Biosynthetic Circuit and their Actions with Human Neutrophils

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Cell-Cell Interactions in the Release of Inflammatory Mediators

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 314))

Abstract

Signal transduction in inflammatory cells is associated with the release and oxygenation of arachidonic acid by lipoxygenases (1, 2). The lipoxins (LX) are a recent addition to the family of biologically active products generated from arachidonic acid collectively termed eicosanoids. Members of the LX series contain a conjugated tetraene structure (3) and display a unique spectrum of bioactivities which distinguish them from other eicosanoids (3, 4). Along these lines, recent results from several laboratories (5–9) indicate that LXA4** blocks some of the “proinflammatory” actions of leukotrienes. Taken together they suggest that LX may serve as chalones in inflammatory responses. Therefore, complete knowledge of their biosynthesis, temporal association of formation and relationship to other eicosanoids is essential to unraveling the functions of these tetraene-containing eicosanoids in inflammation as well as other physiologic events.

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  1. Hematology Division, Brigham and Women’s Hospital and Harvard Medical School, Boston, Mass, USA

    Stefano Fiore, Mark E. Brezinski, Kelly-Ann Sheppard & Charles N. Serhan

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  1. New York Medical College, Valhalla, New York, USA

    Patrick Y.-K. Wong

  2. Harvard Medical School, Boston, Massachusetts, USA

    Charles N. Serhan

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Fiore, S., Brezinski, M.E., Sheppard, KA., Serhan, C.N. (1991). The Lipoxin Biosynthetic Circuit and their Actions with Human Neutrophils. In: Wong, P.YK., Serhan, C.N. (eds) Cell-Cell Interactions in the Release of Inflammatory Mediators. Advances in Experimental Medicine and Biology, vol 314. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-6024-7_7

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