Abstract
Studies on the actions of the NE fiber system in the CNS have traditionally been conducted along two primary dimensions. At the systems level a major issue has been to resolve the consequences of NE release on circuit functions in noradren-ergically innervated areas. At the cellular level, the major question is how noradrenergic receptor activation leads to subsequent membrane actions and how such effects relate to events seen at the synaptic level. Our experience from past investigations is that there is a critical synergy between these two levels of analysis, and that progress at one level may generate insights critical for pursuing issues at the other.
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References
Burne, R.A., and Woodward, D.J., 1983, Visual cortical projections to the paraflocculus in the rat. an electrophysiologic study. Exp. Brain Res., 49:55–67.
Burne, R.A., Mihailoff, G.A., and Woodward, D.J., 1978, Visual corticopontine input to the paraflocculus: a combined autoradiographic and horseradish peroxidase study. Brain Res., 143:139–146.
Hoffer, B.J., Siggins, G.R., Oliver, A.P., and Bloom, F.E., 1973, Activation of the pathway from locus coeruleus to rat cerebellar Purkinje neurons: pharmacological evidence of noradrenergic central inhibition. J. Pharmacol. Exp. Ther., 184:553–569.
Madison, D.V., and Nicoll, R.A., 1986, Cyclic adenosine 3’,5’-monophosphate mediates -receptor actions of noradrenaline in rat hippocampal pyramidal cells. J. Physiol. (Lond.), 372:245–259.
Miyahara, S., and Oomura, Y., 1982, Inhibitory action of the ventral noradrenergic bundle on the lateral hypothalamic neurons through alp noradrenergic mechanisms in the rat. Brain Res., 234:459–463.
Moises, H.C., Waterhouse, B.D., and Woodward, D.J., 1983, Locus coeruleus stimulations potentiates local inhibitory processes in rat cerebellum. Brain Res. Bull., 10:795–804.
Moises, H.C., Waterhouse, B.D., and Woodward, D.J., 1981, Locus coeruleus stimulations potentiates Purkinje cell responses to afferent input: the climbing fiber system. Brain Res., 222:43–64.
Moises, H.C., and Woodward, D.J., 1980, Potentiation of GABA inhibitory action in cerebellum by locus coeruleus stimulation. Brain Res., 182:327–344.
Moises, H.C., Woodward, D.J., Hoffer, B.J., and Freedman, R., 1979, Interactions of norepinephrine with Purkinje cell responses to putative amino acid neuro-transmitters applied by microiontophoresis. Exp. Neurol., 64:48 9–515.
Moises, H.C., Burne, R.A., and Woodward, D.J., Modification of the visual response properties of cerebellar neurons by norepinephrine. Brain Res. (In review).
Nakai, Y., and Takaori, S., 1974, Influence of norepinephrine-containing neurons derived from the locus coeruleus on lateral geniculate neuronal activities ofcats. Brain Res., 71:47–60.
Olpe, H., Glatt, A., Lazlo, J., and Schellenberg, A., 1980, Some electrophysiological and pharmacological properties of the cortical, noradrenergic projection of the locus coeruleus in the rat. Brain Res., 186:9–19.
Phillis, H.W., Tebecis, A.K., and York, D.H., 1967, The inhibitory action of monoamines on lateral geniculate neurones. J. Physiol., 190:563–581.
Segal, M., and Bloom, F.E., 1974, The action of norepinephrine in the rat hippocampus. I., Iontophoretic studies. Brain Res., 107:513–525.
Sessler, F.M., Mouradian, R.D., Cheng, J.-T., Yeh, H.H., Liu, W., and Waterhouse, B.D., 1989, Noradrenergic potentiation of cerebellar Purkinje cell responses to GABA: evidence for mediation through the -adrenoceptor-coupled cyclic AMP system. Brain Res., 499:27–38.
Siggins, G.R., Oliver, A.P., Hoffer, B.J., and Bloom, F.E., 1971, Cyclic adenosine monophosphate and norepinephrine: effects on transmembrane properties of cerebellar Purkinje cells. Science, 171:192–194.
Sweetnam, P.M., Tallman, J.F., Gallager, D.W., and Nestler, E.J., 1987, Phosphorylation of a subunit of the GABA/benzodiazepine receptor by a receptor-associated protein kinase. Soc. Neurosci. Abstr., 13:964.
Waterhouse, B.D., Sessler, F.M., Cheng, J.-T., Woodward, D.J., Azizi, S.A., and Moises, H.C., 1988, New evidence for a gating action of norepinephrine in central neuronal circuits of mammalian brain. Brain Res. Bull., 21:425–432.
Waterhouse, B.D., Sessler, F.M., Cheng, J.-T., and Yeh, H.H., 1987, Noradrenergic potentiation of cerebellar Purkinje cell responses to GABA: evidence for mediation by an intracellular second messenger system. Soc. Neurosci. Abstr., 13:1347.
Waterhouse, B.D., Moises, H.C., Yeh, H.H., and Woodward, D.J., 1982, Norepinephrine enhancement of inhibitory synaptic mechanisms in cerebellum and cerebral cortex: mediation by beta adrenergic receptors. J. Pharmacol. Exp. Ther., 221:495–50 6.
Waterhouse, B.D., Moises, H.C., and Woodward, D.J., 1981, Alpha receptor mediated facilitation of somatosensory cortical neuronal responses to excitatory synaptic inputs and iontophoretically applied acetylcholine. Neuropharmacology, 20:907–920.
Waterhouse, B.D., Moises, H.C., and Woodward, D.J., 1980, Noradrenergic modulation of somatosensory cortical neuronal responses to iontophoretically applied putative neurotransmitters. Exp. Neurol., 69:30–49.
Waterhouse, B.D., and Woodward, D.J., 1980, Interaction of norepinephrine with cerebro-cortical activity evoked by stimulation of somatosensory afferent pathways. Exp. Neurol., 67:22–34.
Waterhouse, B.D., Azizi, S.A., Burne, R.A., and Woodward, D.J., Modulation of rat cortical area 17 neuronal responses to moving visual stimuli during norepinephrine and serotonin microiontophoresis.
Woodward, D.J., Waterhouse, B.D., Hoffer, B.J., and Freedman, R., 1979, Modulatory actions of norepinephrine in the central nervous system. Fed. Proc., 38:2109–2116.
Yeh, H.H., and Woodward, D.J., 1983a, Beta-I adrenergic receptors mediate noradrenergic facilitation of Purkinje cell responses to gammaaminobutyric acid in cerebellum of rat. Neuropharmacology, 22:62 9–639.
Yeh, H.H., and Woodward, D.J., 1983b, Noradrenergic action in the developing rat cerebellum: interaction between norepinephrine and -aminobutyric acid applied microiontophoretically to immature Purkinje cells. Develop. Brain Res., 10:49–62.
Yeh, H.H., and Woodward, D.J., 1983c, Alterations in beta adrenergic physiological response characteristics after long-term treatment with desmethyl imipramine: interaction between norepinephrine and -aminobutyric acid in rat cerebellum. J. Pharmacol. Exp. Ther., 226:126–134.
Yeh, H.H., and Woodward, D.J., 1983d, Noradrenergic action in the developing rat cerebellum: interaction between norepinephrine and synaptically-evoked responses of immature Purkinje cells. Develop. Brain Res., 11:207–218.
Yeh, H.H., Moises, H.C., Waterhouse, B.D., and Woodward, D.J., 1981, Modulatory interactions between norepinephrine and taurine, betaalanine, gamma-aminobutyric acid and muscimol, applied iontophoretically to cerebellar Purkinje cells. Neuropharmacology, 20:549–560.
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© 1991 Plenum Press, New York
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Woodward, D.J., Moises, H.C., Waterhouse, B.D., Yeh, H.H., Cheun, J.E. (1991). Modulatory Actions of Norepinephrine on Neural Circuits. In: Kito, S., Segawa, T., Olsen, R.W. (eds) Neuroreceptor Mechanisms in Brain. Advances in Experimental Medicine and Biology, vol 287. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5907-4_16
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DOI: https://doi.org/10.1007/978-1-4684-5907-4_16
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