Skip to main content

Immunomodulation of Pre-Diabetes in BB Rats for Prevention of the Disease

  • Chapter
Prediabetes

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 246))

  • 124 Accesses

Abstract

The use of insulin therapy in the treatment of diabetes was naturally heralded as a cure for this otherwise lethal malady (1). It has now become apparent that, although insulin therapy avoids the acute morbidity and mortality associated with the disease, it allows those afflicted to develop a host of chronic debilitating complications. To eliminate such complications it seems likely that more refined treatment modalities and/or effective disease prevention strategies will be necessary, and that this will require further understanding the pathogenesis of insulin dependent diabetes mellitus (IDDM).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Banting, F.G., Best, C.H., 1922, The internal secretion of the pancreas. J. Lab. Clin. Med. 251–266.

    Google Scholar 

  2. Opie, E.L., 1900–1901, The relation of diabetes mellitus to lesions of the pancreas. J.Exp. Med. 5:527–540.

    Article  PubMed  CAS  Google Scholar 

  3. VonMeyenburg, H., 1940, Ueber “Insulitus” bei diabetes. Schweiz Med. Wochenschr. 21:554.

    Google Scholar 

  4. Irvine, W.J., 1980, Immunological Aspects of Diabetes Mellitus: A Review (including the salient points of NDDG report on the classification of diabetes). In Immunology of Diabetes, Irvine, W.J., ed. Edinburgh, Teviot Scientific Publications, p. 1.

    Google Scholar 

  5. Stiller, C.R., Dupre, J., Gent, M., Venmer, M.R., Keown, P.A., I Laupacis, A., Martell, P., Rodger, N.W., Groffemed, B.V., and Wolfe, B.J.J., 1984, Effect of cyclosporine immunosuppression in insulin dependent diabetes-mellitus of recent onset. Science 223: 1363–1367.

    Article  Google Scholar 

  6. Marliss, E.B., Nakhooda, A.F., Poussier, P., Sima, A.A.F., 1982, The diabetic syndrome of the BB Wistar rat: possible relevance to type I I (insulin-dependent) diabetes in man. Diabetologia 22:225–232.

    Article  PubMed  CAS  Google Scholar 

  7. Fuks, A., Colle, E., Ono, S., Prud’homme, G., Seemayer, T., and Guttman, R.D., 1988, Immunogenetic studies of insulin-dependent diabetes in the BB rat. In: Frontiers in Diabetes Research, (Shafir, E., and Renold, A.E., eds.) London, John Libbey, p. 29.

    Google Scholar 

  8. Like, A.A., Guberski, D.L., and Butler, L, 1986, Diabetic biobreeding/ worester (BB/Wor) rats need not be lymphopenic. J. of Immunol. 3254–58.

    Google Scholar 

  9. Greiner, D.L., Mordes, J.P., Handler, E.S., Angelillo, M., Nakamura, N., Rossini, A.A., 1987, Depletion of RT6. 1+ T lymphocytes induces diabetes in resistant Biobreeding/Worcester (BB/W) rats. J. Exp. Med. 166:461–75.

    Article  PubMed  CAS  Google Scholar 

  10. Mordes, J.P., Desemone, J., Rossini, A.A., 1987, The BB rat. Diabetes/ Metabolism Reviews 3:725–750.

    Article  PubMed  CAS  Google Scholar 

  11. Naji, A., Silvers, W.K., Bellgrau, D., Barker C.F., 1981, Spontaneous diabetes in rats: destruction of islets is prevented by immunological tolerance. Science 213:1390–1392.

    Article  PubMed  CAS  Google Scholar 

  12. Naji, A., Silvers, W.K., Kimura, H., Bellgrau, D., Markmann, J.F., and Barker, C.F., 1983, Analytical and functional studies on the T cells of untreated and immunologically tolerant diabetes prone BB rats. J. Immunol. 130:2168–2172.

    PubMed  CAS  Google Scholar 

  13. Francfort, J.W., Naji, A., Silvers, W.K., and Barker, C.F., 1985, The influence of T-lymphocyte precursor cells and thymus grafts on the cellular immunodeficiencies of the BB rat. Diabetes, Vol. 34, No. 11:1134–38.

    Article  PubMed  CAS  Google Scholar 

  14. Brayman, K.L., Markmann, J.F., Barker, C.F., and Naji, A., 1988, Immunoprediction of diabetes and evaluation of pancreatic islet transplantation during the prediabetic period. Surgery 4:445–451.

    Google Scholar 

  15. Brayman, K.L., Markmann, J.F., Silvers, W.K., Barker, C.F., and Naji, A., 1987, The immunoregulation of autoimmune diabetes in BB rats is MHC-restricted. Diabetes 36 (Suppl. 1):65A.

    Google Scholar 

  16. Brayman, K.L., Markmann, J.F., Barker, C.F., and Naji, A., 1988, Prevention of diabetes in BB rats requires lymphocytes functionally restricted to MHC-compatible thymic determinants. Diabetes 37 (Supp. I); 55A.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1988 Plenum Press, New York

About this chapter

Cite this chapter

Markmann, J.F., Naji, A., Barker, C.F., Brayman, K.L. (1988). Immunomodulation of Pre-Diabetes in BB Rats for Prevention of the Disease. In: Camerini-Davalos, R.A., Cole, H.S. (eds) Prediabetes. Advances in Experimental Medicine and Biology, vol 246. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5616-5_44

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-5616-5_44

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5618-9

  • Online ISBN: 978-1-4684-5616-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics