Abstract
Bryostatins are macrocyclic lactones derived from the marine bryozoan Bugula neritina and are currently being investigated for their apparent anti-neoplastic activities.1,2 In addition, certain bryostatins have been shown to share certain properties with the tumor promoting compound 12-O-tetradecanoylphorbol 13-acetate (TPA). These properties include the activation of human neutrophils to generate superoxide anion and the release of specific granules3. In vitro, certain bryostatins also appear to bind and activate the TPA receptor protein kinase-C (PK-C), a process which results in the phosphorylation of nearly identical protein substrates phosphorylated by TPA3.
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References
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G.R. Pettit, C.L. Herald and Y. Kamano, The structure of the Bugula neritina (marine, bryozoa) antineoplastic component Bryostatin 3, J. Org. Chem. 48:5354 (1983).
R.L. Berkow and A.S. Kraft, Bryostatin, a non-phorbol macrocyclic lactone, activates intact human polymorphonuclear leukocytes and binds to the phorbol ester receptor, Biochem. Biophys. Res. Comm. 131:1109 (1985).
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© 1988 Plenum Press, New York
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Warren, J.T., Esa, A.H., Pettit, G.R., May, W.S. (1988). Bryostatin Stimulation of Human Neutrophil Luminol and DBA (Lucigenin) Chemiluminescence. In: Simic, M.G., Taylor, K.A., Ward, J.F., von Sonntag, C. (eds) Oxygen Radicals in Biology and Medicine. Basic Life Sciences, vol 49. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5568-7_34
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DOI: https://doi.org/10.1007/978-1-4684-5568-7_34
Publisher Name: Springer, Boston, MA
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