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Immune Cells and Bone Resorption

  • Chapter
Phosphate and Mineral Homeostasis

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 208))

Abstract

The concept of interactions between cells of the immune system and bone in the control of bone turnover is far from new. The relationship between haematopoietic precursor cells and the osteoclast has long been recognised and studies on animals with congenital bone diseases such as osteopetrosis have identified defective components of the immune system as causing or contributing to the disease. For example, the op/op (osteopetrotic) rat exhibits thymic atrophy and the disease can be cured by either administration of normal bone marrow cells or by thymus transplant l. Several mutant rodents have been described in which the osteopetrosis can be cured by injection of bone marrow, spleen or thymocytes l. These studies suggest that a functioning immune system is necessary for the normal activity of the bone resorbing cells.

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Authors and Affiliations

  1. Department of Human Metabolism & Clinical Biochemistry, University of Sheffield Medical School, Beech Hill Road, Sheffield, S10 2RX, UK

    M. Gowen, B. R. MacDonald, D. E. Hughes, H. Skjodt & R. G. G. Russell

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  1. M. Gowen
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  2. B. R. MacDonald
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  3. D. E. Hughes
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  4. H. Skjodt
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  5. R. G. G. Russell
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Editor information

Editors and Affiliations

  1. University of Southern California, Los Angeles, California, USA

    Shaul G. Massry

  2. University of Aix-Marseille, Marseille, France

    Michel Olmer

  3. University of Heidelberg, Heidelberg, Federal Republic of Germany

    Eberhard Ritz

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© 1986 Plenum Press, New York

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Gowen, M., MacDonald, B.R., Hughes, D.E., Skjodt, H., Russell, R.G.G. (1986). Immune Cells and Bone Resorption. In: Massry, S.G., Olmer, M., Ritz, E. (eds) Phosphate and Mineral Homeostasis. Advances in Experimental Medicine and Biology, vol 208. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5206-8_33

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  • DOI: https://doi.org/10.1007/978-1-4684-5206-8_33

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5208-2

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