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Reconstitution of the Regulatory Functions of β-Adrenergic Receptors

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Neurotransmitter Receptors

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 175))

Abstract

The hormone-sensitive adenylate cyclase system acts as the intracellular effector for numerous neurotransmitters and hormones whose receptors are located on the cell surface. Multiple inhibitory and stimulatory receptors with specificities for different ligands can act simultaneously on a single target cell to modulate the activity of adenylate cyclase on the inner face of the plasma membrane. In addition to acute control, several different mechanisms exist for the long-term regulation of the enzyme, of individual receptors, and of the coupling process. Inhibitory control of adenylate cyclase is discussed by Drs. Ui and Aktories in this volume, and Harden (1) has thoroughly reviewed refractoriness and other modes of chronic regulation of adenylate cyclase recently. Here, we will discuss the biochemical events that couple transmitter binding to its receptor with the stimulation of adenylate cyclase.

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Author information

Authors and Affiliations

  1. Department of Pharmacology, University of Texas Health Science Center at Dallas, Dallas, Texas, USA

    Elliott M. Ross, Tomiko Asano, Steen E. Pedersen & Douglas R. Brandt

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  1. Elliott M. Ross
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  2. Tomiko Asano
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  3. Steen E. Pedersen
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  4. Douglas R. Brandt
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Editor information

Editors and Affiliations

  1. Third Department of Internal Medicine, Hiroshima University School of Medicine, 1-2-3 Kasumi, Minamiku, Hiroshima 734, Japan

    Shozo Kito M.D., Ph.D.

  2. Department of Pharmacology Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine, 1-2-3 Kasumi, Minamiku, Hiroshima 734, Japan

    Tomio Segawa Ph.D.

  3. Department of Pharmacology, Kyoto Prefectural University of Medicine, Kawaramachi, Hirokoji, Kamikyoku Kyoto 602, Japan

    Kinya Kuriyama M.D.

  4. Departments of Pharmacology, Biochemistry, Psychiatry and the Arizona Research Laboratories, University of Arizona Health Sciences Center, 85724, Tucson, Arizona, USA

    Henry I. Yamamura Ph.D.

  5. Department of Pharmacology, University of California, Los Angeles School of Medicine, 90024, Los Angeles, California, USA

    Richard W. Olsen Ph.D.

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© 1984 Plenum Press, New York

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Ross, E.M., Asano, T., Pedersen, S.E., Brandt, D.R. (1984). Reconstitution of the Regulatory Functions of β-Adrenergic Receptors. In: Kito, S., Segawa, T., Kuriyama, K., Yamamura, H.I., Olsen, R.W. (eds) Neurotransmitter Receptors. Advances in Experimental Medicine and Biology, vol 175. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-4805-4_4

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  • DOI: https://doi.org/10.1007/978-1-4684-4805-4_4

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4684-4807-8

  • Online ISBN: 978-1-4684-4805-4

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