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Monoclonal Antibodies as Physiologic Probes

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Basic Biology of New Developments in Biotechnology

Part of the book series: Basic Life Sciences ((BLSC))

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Abstract

Clinicians and research scientists alike have for years utilized the immune response to generate antibodies to probe physiologic and biochemical systems. Polyclonal antibody found in the course of the humoral response to an antigen may detect, quantify, and localize small amounts of material in complex mixtures. Were it not for the heterogeneity and unpredictability of the immune reponse, immunologic assays might have had an even greater application. With the introduction of somatic cell fusion most of the problems associated with polyclonal antisera and their application to basic and clinical questions are likely to be overcome.

This work was supported by NIH grant HL-19529, NCI grant //CA-17393, USPH grant AM-16791, and the Specialized Center for Research in Ischemic Heart Disease grant #HL-26215.

Dr. Mudgett-Hunter is a recipient of Established Investigator Award #79-189 from the American Heart Association.

Dr. Budzik is a recipient of the Charles A. King Trust Fellowship, Medical Research Foundation.

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Author information

Authors and Affiliations

  1. Cardiac Unit, Harvard Medical School, Boston, Massachusetts, 02114, USA

    M. Mudgett-Hunter, B. A. Khaw & E. Haber

  2. Pediatric Surgical Unit, Harvard Medical School, Boston, Massachusetts, 02114, USA

    G. P. Budzik & P. K. Donahoe

  3. Thyroid Unit, Massachusetts General Hospital, Boston, Massachusetts, 02114, USA

    E. C. Ridgeway

  4. Harvard Medical School, Boston, Massachusetts, 02114, USA

    M. N. Margolies

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  1. M. Mudgett-Hunter
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Editors and Affiliations

  1. Associated Universities, Inc., Washington, D.C., USA

    Alexander Hollaender

  2. Exxon Research and Engineering Co., Linden, New Jersey, USA

    Allen I. Laskin

  3. University of Minnesota Medical School, Minneapolis, Minnesota, USA

    Palmer Rogers

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© 1983 Plenum Press, New York

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Mudgett-Hunter, M. et al. (1983). Monoclonal Antibodies as Physiologic Probes. In: Hollaender, A., et al. Basic Biology of New Developments in Biotechnology. Basic Life Sciences. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4460-5_8

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  • DOI: https://doi.org/10.1007/978-1-4684-4460-5_8

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4462-9

  • Online ISBN: 978-1-4684-4460-5

  • eBook Packages: Springer Book Archive

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