Abstract
Drugs which produce dependence have one characteristic in common: in effective doses, they induce alteration in behavior. This characteristic, however, does not define addictive drugs, since other drugs modify behavior without inducing addiction. The behavioral responses to addictive drugs do indicate the central nervous system as the target tissue, and nervous function as the site of drug intervention, during the development of dependence to chronic use of opiates or other drugs which produce dependence.
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Clouet, D.H. (1973). Effects of Narcotic Analgesics on Brain Function. In: Gaull, G.E. (eds) Biology of Brain Dysfunction. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2670-0_3
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