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Sequence Specificity and Biological Consequences of Drugs that Bind Covalently in the Minor Groove of DNA

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Mechanisms of DNA Damage and Repair

Part of the book series: Basic Life Sciences ((BLSC,volume 189))

Abstract

A variety of synthetic and naturally occurring DNA ligands have been shown to bind partially or totally within the minor groove of B-form DNA. The distamycins, netropsin, stilbamidine, and SN18071 all associate noncovalently with the minor groove1,2 while the intercalators adriamycin and actinoraycin have substituents which reside in the minor groove and stabilize their respective complexes. The pyrrolo(l,4)benzodiazepine [P(1,4)B] antitumor antibiotics, anthramycin, tomaymycin, and sibiromycin (see Figure 1) bind covalently in the minor groove to N2 of guanine.3,4 CC-1065, another antitumor antibiotic, binds covalently to N3 of adenine in the minor groove of DNA.5,6

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References

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Authors and Affiliations

  1. Drug Dynamics Institute, College of Pharmacy, University of Texas at Austin, Austin, TX, 78712, USA

    Laurence H. Hurley & Donald R. Needham-VanDevanter

Authors
  1. Laurence H. Hurley
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  2. Donald R. Needham-VanDevanter
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Editor information

Editors and Affiliations

  1. National Bureau of Standards, Gaithersburg, Maryland, USA

    Michael G. Simic

  2. Chemistry Department, American University, Washington, D.C., USA

    Michael G. Simic

  3. Johns Hopkins University, Baltimore, Maryland, USA

    Lawrence Grossman

  4. New York University Medical Center, New York, New York, USA

    Arthur C. Upton

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© 1986 Plenum Press, New York

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Hurley, L.H., Needham-VanDevanter, D.R. (1986). Sequence Specificity and Biological Consequences of Drugs that Bind Covalently in the Minor Groove of DNA. In: Simic, M.G., Grossman, L., Upton, A.C., Bergtold, D.S. (eds) Mechanisms of DNA Damage and Repair. Basic Life Sciences, vol 189. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9462-8_21

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  • DOI: https://doi.org/10.1007/978-1-4615-9462-8_21

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-9464-2

  • Online ISBN: 978-1-4615-9462-8

  • eBook Packages: Springer Book Archive

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