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Effects of LET∞ on the Fate of DNA Damage Induced in Rabbit Sensory Cells In Situ: Fundamental Aspects

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Mechanisms of DNA Damage and Repair

Part of the book series: Basic Life Sciences ((BLSC,volume 189))

Abstract

For half a century, radiobiological theory was dominated by the notion that cellular radiosensitivity to ionizing radiations could be explained solely on the basis of the physics of energy deposition1,2. The process was extended even to explanations for the variation in relative biological effectiveness (RBE) with increased linear energy transfer (LET∞ ) associated with densely-ionizing, particulate radiations3,4 In more recent years, examination of the radiation responses of the repair-deficient S/S variant of the L5178Y murine leukemic lymphoblast has demonstrated that radiobiological theories which do not incorporate metabolic modification of radiochemical damage are untenable2.

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Author information

Authors and Affiliations

  1. Dept. Radiology & Radiation Biology, Colorado State Univ. Ft., Collins, CO, 80523, USA

    J. T. Lett, D. S. Bertold & P. C. Keng

  2. Center for Radiation Res., Natl. Bureau of Standards, Gaithersburg, MD, 20899, USA

    D. S. Bertold

  3. Cancer Center Univer. of Rochester Medical Center, Rochester, NY, 14627, USA

    P. C. Keng

Authors
  1. J. T. Lett
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  2. D. S. Bertold
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  3. P. C. Keng
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Editor information

Editors and Affiliations

  1. National Bureau of Standards, Gaithersburg, Maryland, USA

    Michael G. Simic

  2. Chemistry Department, American University, Washington, D.C., USA

    Michael G. Simic

  3. Johns Hopkins University, Baltimore, Maryland, USA

    Lawrence Grossman

  4. New York University Medical Center, New York, New York, USA

    Arthur C. Upton

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© 1986 Plenum Press, New York

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Lett, J.T., Bertold, D.S., Keng, P.C. (1986). Effects of LET∞ on the Fate of DNA Damage Induced in Rabbit Sensory Cells In Situ: Fundamental Aspects. In: Simic, M.G., Grossman, L., Upton, A.C., Bergtold, D.S. (eds) Mechanisms of DNA Damage and Repair. Basic Life Sciences, vol 189. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9462-8_15

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  • DOI: https://doi.org/10.1007/978-1-4615-9462-8_15

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-9464-2

  • Online ISBN: 978-1-4615-9462-8

  • eBook Packages: Springer Book Archive

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