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Pharmacology of Thyrotropin Releasing Factor (TRF), Luteinizing Hormone Releasing Factor (LRF), and Somatostatin

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Hypothalamic Peptide Hormones and Pituitary Regulation

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 87))

Abstract

It is now apparent that the three characterized hypothalamic hypo-physiotropic regulatory peptides have powerful biological activities on the pituitary gland, central nervous system, and, in the case of somatostatin, the gastrointestinal tract and pancreas. The distribution of these peptides and a variety of immunological, physiological, and clinical studies have suggested that these peptides possess important physiological functions in each of these organ systems and could, under some circumstances, play pathophysiologic roles as well. In order to study and exploit these biologically important peptides, synthetic analogs have been developed which can be used for several investigational and clinical purposes.

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References

  1. Burgus, R., M. Butcher, M. Amoss, N. Ling, M. Monahan, J. Rivier, R. Fellows, R. Blackwell, W. Vale, and R. Guillemin, “Primary structure of the hypothalamic luteinizing hormone-releasing factor (LRF) of ovine origin,” Proc Natl Acad Sci USA 69: 278–282, 1972.

    Article  PubMed  CAS  Google Scholar 

  2. Matsuo, H., Y. Baba, R. Nair, A. Arimura, and A. Schally, “Structure of the porcine LH-and FSH-releasing hormone. I. Proposed amino acid sequence,” Biochem Biophys Res Commun 43: 1334–1339, 1971.

    Article  PubMed  CAS  Google Scholar 

  3. Momany, F.A., “Conformational energy analysis of the molecule, luteinizing hormone releasing hormone. 2. Tetrapeptide and decapeptide analogues,” J. Am Chem Soc 98: 2996–3000, 1976.

    Article  PubMed  CAS  Google Scholar 

  4. Rivier, J., M. Brown, C. Rivier, N. Ling, and W. Vale, “Hypothalamic hypophysiotropic hormones,” Peptides 1976, A. Loffet (ed.), Editions de TUniversites de Bruxelles, Brussels, 1976, pp. 427–451.

    Google Scholar 

  5. Vale, W., C. Rivier, and M. Brown, “Regulatory peptides of the hypothalamus,” Ann Rev Physiol 39: 473–527, 1977.

    Article  CAS  Google Scholar 

  6. Monahan, M., M. Amoss, H. Anderson, and W. Vale, “Synthetic analogs of the hypothalamic luteinizing hormone releasing factor with increased agonist or antagonist properties,” Biochemistry 12: 4616–4620, 1973.

    Article  PubMed  CAS  Google Scholar 

  7. Coy, D., J. Vilchez-Martinez, E. Coy. J.N. Nishi, A. Arimura, and A. Schally, “Polyfluroralkylamine derivatives of luteinizing hormone-releasing hormone,” Biochemistry 14: 1848, 1973.

    Article  Google Scholar 

  8. Rivier, J., N. Ling, M. Monahan, C. Rivier, M. Brown, and W. Vale, “Luteinizing hormone releasing factor and somatostatin analogs,” Peptides Chemistry, Structure, Biology, R. Walter and J. Meienhofer (eds.), Ann Arbor Science, Ann Arbor, Michigan, 1975, pp. 863–870.

    Google Scholar 

  9. Tyrrell, J.B., M. Lorenzi, J.E. Gerich, and P. Forsham, “Inhibition by somatostatin of ACTH secretion in Nelson’s syndrome,” J. Clin Endocrinol Metab 40: 1125–1127, 1975.

    Article  PubMed  CAS  Google Scholar 

  10. Vale, W., C. Rivier, M. Brown, J. Leppaluoto, N. Ling, M. Monahan, and J. Rivier, “Pharmacology of hypothalamic regulatory peptides,” Clin Endocrinol 5: 261–273, 1976.

    Article  Google Scholar 

  11. Fujino, M., I. Yamazaki, S. Kobayashi, T. Fukada, S. Shinagawa, and R. Nakayama, “Some analogs of luteinizing hormone releasing hormone (LH-RH) having intense ovulation-inducing activity,” Biochem Biophys Res Commun 57: 1248–1256, 1974.

    Article  PubMed  CAS  Google Scholar 

  12. Ling, N., and W. Vale, “Analogs of luteinizing hormone releasing factor (LRF). Synthesis and biological activity of [Nα-Me-Leu7]-LRF,” Biochem Biophys Res Commun 63: 801–806, 1975.

    Article  PubMed  CAS  Google Scholar 

  13. Konig, W., J. Sandow, and R. Greiger, “Structure-function relationships of LH-RH/FSH-RH,” Peptides: Chemistry, Structure and Biology, R. Walter and J. Meienhoffer (eds.), Ann Arbor Science, Ann Arbor, Michigan, 1975, pp. 175–179.

    Google Scholar 

  14. Coy, D., E. Coy, A. Schally, J. Vilchez-Martinez, Y. Hirotsu, and A. Arimura, “Synthesis and biological properties of [D-Ala6,Des-Gly-NH2-10]-LH-RH ethylamide, a peptide with greatly enhanced LH-and FSH-releasing activity,” Biochem Biophys Res Commun 57: 335–340, 1974.

    Article  PubMed  CAS  Google Scholar 

  15. Vale, W., C. Rivier, J. Rivier, N. Ling, M. Monahan, and R. Guillemin, “Synthetic and native substances modifying secretion of gonadotropins,” Endocrinology 96: A99, 1975.

    Google Scholar 

  16. Coy, D., E. Coy, A. Schally, E. Vilchez-Martinez, Y. Hirotsu, and A. Arimura, “Synthesis and biological properties of TD-Ala6,Des-Gly-NH2-10]-LH-RH ethylamide, a peptide with greatly enhanced LH-and FSH-releasing activity,” Biochem Biophys Res Commun 57: 335–340, 1974.

    Article  PubMed  CAS  Google Scholar 

  17. Jeffcoate, S.L., D. Holland, N. White, H. Fraser, A. Gunn, D. Crighton, J. Foster, E. Griffiths, K. Hooper, and P. Sharp, “The radioimmunoassay of hypothalamic hormones (TRH and LHRH) and related peptides in biological fluids” Hypothalamic Hormones: Chemistry, Physiology, Pharmacology and Clinical Uses, M. Motta, P. Crosignani, and L. Martini (eds), Academic Press, New York, 1975, pp. 279–298.

    Google Scholar 

  18. Koch, Y., T. Baram, P. Chobsieng, and M. Fridkin, “Enzymatic degradation of luteinizing hormone-releasing hormone (LH-RH) by hypothalamic tissue,” Biochem Biophys Res Commun 61: 95–103, 1974.

    Article  PubMed  CAS  Google Scholar 

  19. Griffiths, E., K. Hooper, S. Jeffcoate, and D. Holland, “Possible control of luteinizing hormone releasing hormone by enzymatic degradation,” Lancet 2: 862, 1973.

    Article  PubMed  CAS  Google Scholar 

  20. Koch, Y., T. Baram, P. Chobsieng, and M. Fridkin, “Enzymatic degradation of luteinizing hormone-releasing hormone (LH-RH) by hypothalamic tissue,” Biochem Biophys Res Commun 61: 95–103, 1974.

    Article  PubMed  CAS  Google Scholar 

  21. Marks, N., and F. Stern, “Enzymatic mechanisms for the inactivation of luteinizing hormone-releasing hormone (LH-RH),” Biochem Biophys Res Commun 61: 1458–1463, 1974.

    Article  PubMed  CAS  Google Scholar 

  22. Rippel, R., E. Johnson, W. White, M. Fujino, I. Yamazaki, and R. Nakayama, “Ovulating and LH-releasing activity of a highly potent analog of synthetic gonadotropin-releasing hormone,” Endocrinology 93: 1449–1452, 1973.

    Article  PubMed  CAS  Google Scholar 

  23. Mortimer, CH., G.M. Besser, and A.S. McNeilly, “Gonadotropin releasing hormone therapy in the induction of puberty, potency, spermatogenesis and ovulation in patients with hypothalamic-pituitary-gonadal dysfunction,” Hypothalamic Hormones, M. Motta, P. Crosignani, and L. Martini (eds.), Academic Press, New York, 1975 pp. 325–336.

    Google Scholar 

  24. Schwarzstein, L., “Diagnostic and therapeutic use of LH-RH in the infertile man” Hypothalamus and Endocrine Functions, F. Labrie, J. Meites, and G. Pelletier (eds.), Plenum Press, New York, 1975, pp. 73–92.

    Google Scholar 

  25. Johnson, E., R.L. Gendrich, and W. White, “Delay of puberty and inhibition of reproductive processes in the rat by a gonadotropin-releasing hormone agonist analog,” Fertil Steril 27: 853–860, 1976.

    PubMed  CAS  Google Scholar 

  26. Rivier, C., J. Rivier, and W. Vale, “Effects of [F-Trp6,Pro9-NEt]-LRF on reproductive processes in the female rat,” Endocrinology (submitted).

    Google Scholar 

  27. Beattie, C.W., and A. Corbin, “Pre-and Post-coital contraceptive activity of luteinizing hormone-releasing hormone (LHRH) in rats,” 58th Annual Meeting of Endocrine Society, San Francisco, 1976, p. 283, (Abstract no. 452).

    Google Scholar 

  28. Lin, Y.C., and K. Yoshinaga, “Inhibitory effect of GN-LH on ovum implantation in the rat,” 58th Annual Meeting of Endocrine Society, San Francisco, 1976, p. 143 (Abstract no. 174).

    Google Scholar 

  29. Dufau, M.L., L.Z. Beitins, J.W. McArthur, and I.J. Catt, “Effects of luteinizing hormone releasing hormone (LHRH) upon bioactive and immunoactive serum LH levels in normal subjects,” J. Clin Endocrinol Metab 43: 658–667, 1976.

    Article  PubMed  CAS  Google Scholar 

  30. Diebel, N.D., M. Yamanoto, and E.M. Bogdanove, “Discrepancies between radioimmunoassays and bioassay for rat FSH: evidence that androgen treatment and withdrawal can alter bioassay-immunoassay ratios,” Endocrinology 92: 1065–1078, 1973.

    Article  PubMed  CAS  Google Scholar 

  31. Conti, M., J.P. Harwood, A.J.W. Hsueh, M.L. Dufau, and K.J. Catt, “Gonadotropin-induced loss of hormone receptors and desensitization of adenylate cyclase in the ovary,” J. Biol Chem 251: 7729–7731, 1976.

    PubMed  CAS  Google Scholar 

  32. Rippel, R.H., and E.S. Johnson, “Regression of corpora lutea in the rabbit after injection of a gonadotropin-releasing peptide,” Proc Soc Exp Biol Med 152: 29–32, 1976.

    PubMed  CAS  Google Scholar 

  33. Vale, W., G. Grant, J. Rivier, M. Monahan, M. Amoss, N. Blackwell, R. Burgus, and R. Guillemin, “Synthetic polypeptide antagonists of the hypothalamic luteinizing hormone releasing factor,” Science 176: 933–934, 1972.

    Article  PubMed  CAS  Google Scholar 

  34. Vale, W., G. Grant, and R. Guillemin, “Chemistry of the hypothalamic releasing factors-studies on structure-function relationships,” Frontiers in Neuroendocrinology, L. Martini and W. Ganong (eds.), Oxford University Press, New York, 1973, pp. 375–413.

    Google Scholar 

  35. Monahan, M., W. Vale, C. Rivier, G. Grant, and R. Guillemin, “Analogues of LRF with inhibitory action or greater potency than the natural decapeptide hormone,” Endocrinology 93: 194A, 1973.

    Google Scholar 

  36. Rees, R., T. Foell, S. Chai, and N. Grant, “Synthesis and biological activities of analogs of the luteinizing hormone-releasing hormone (LH-RH) modified in position 2,” J. Med Chem 17: 1016–1019, 1974.

    Article  PubMed  CAS  Google Scholar 

  37. Monahan, M., M. Amoss, H. Anderson, and W. Vale, “Synthetic analogs of the hypothalamic luteinizing hormone releasing factor with increased agonist or antagonist properties,” Biochemistry 12: 4616–4620, 1973.

    Article  PubMed  CAS  Google Scholar 

  38. Bowers, C.Y., Y.P. Wan, J. Humphries, and K. Folkers, “Studies on inhibition of the luteinizing hormone-releasing hormone by an irreversible inhibitor at the receptor site,” Biochem Biophys Res Commun 61: 648–653, 1974.

    Article  Google Scholar 

  39. Coy, D., A. Schally, J. Vilchez-Martinez, E. Coy, and A. Arimura, “Stimulatory and inhibitory analogs of LH-RH,” Hypothalamic Hormones: Chemistry, Physiology, Pharmacology and Clinical Uses, M. Motta, P. Crosignani, and L. Martini (eds.), Academic Press, New York, 1975, pp. 1–12.

    Google Scholar 

  40. De la Cruz, A., D. Coy, J. Vilchez-Martinez, A. Arimura, and A. Schally, “Blockade of ovulation in rats by inhibitory analogs of luteinizing hormone-releasing hormone,” Science 919: 195–196, 1976.

    Article  Google Scholar 

  41. Humphries, J., Y.P. Wan, and K. Folkers, “Presence of proline in position 3 for potent inhibition of the activity of the luteinizing hormone releasing hormone and of ovulation,” Biochem Biophys Res Commun 72: 839–841, 1976.

    Article  Google Scholar 

  42. De la Cruz, A., D.H. Coy, and A.V. Schally, “Blockade of the Preovulatory LH surge in hamsters by an inhibitory analog of LH-RH,” Proc Soc Exp Biol Med 149: 576–579, 1975.

    Google Scholar 

  43. Beattie, C.W., A. Corbin, T.J. Foell, V. Gorsky, W.A. McKinley, R.W.A. Rees, D. Sarantakis, and J.P. Yardley, “Luteinizing hormone-releasing hormone. Antiovulatory activity of analogs substituted in positions 2 and 6,” J. Med Chem 718: 1247–1253, 1975.

    Article  Google Scholar 

  44. Vale, W., and C. Rivier, “Hypothalamic hypophysiotropic hormones,” Handbook of Psychopharmacology, L.L. Iverson, S.D. Iverson, and S.H. Snyder (edsT), Plenum Press, New York, 1975, pp. 195–238.

    Google Scholar 

  45. Sievertsson, H., J. Chang, K. Folkers, and C. Bowers, “Synthesis of di-and tri-peptides and assay in vivo for activity in the thyrotropin releasing hormone and luteinizing hormone releasing hormone systems,” J Med Chem 15: 3–11, 1972.

    Google Scholar 

  46. Vale, W., G. Grant, and R. Guillemin, “Chemistry of the hypothalamic releasing factors-studies on structure-function relationships,” Frontiers in Neuroendocrinology, L. Martini and W. Ganong (eds.), Oxford University Press, New York, 1973, pp. 375–413.

    Google Scholar 

  47. Hinkle, P., E. Woroch, and A. Tashjian, Jr., “Receptor-binding affinities and biological activities of analogs of thyrotropin-releasing hormone in prolactin-producing pituitary cells in culture,” J. Biol Chem 249: 3085–3090,1974.

    PubMed  CAS  Google Scholar 

  48. Coy, D., Y. Hirotsu, T. Redding, E. Coy, and A. Schally, “Synthesis and biological properties of the 2-L-α-(pyrazolyl-1) alanine analogs of luteinizing hormone-releasing hormone,” J. Med Chem 18: 948, 1975.

    Article  PubMed  CAS  Google Scholar 

  49. Donzel, B., M. Goodman, J. Rivier, N. Ling, and W. Vale, “Synthesis and conformations of hypothalamic hormone releasing factors: two TRF-analogues containing backbone N-methyl groups,” Nature 256: 750–751, 1975.

    Article  PubMed  CAS  Google Scholar 

  50. Redding, T., and A. Schally, “Studies on the inactivation of thyrotropin-releasing hormone (TRH),” Proc Soc Exp Biol Med 131: 415–420, 1967.

    Google Scholar 

  51. Vale, W., R. Burgus, T. Dunn, and R. Guillemin, “In vitro plasma inactivation of thyrotropin releasing factor (TRF) and related peptides: Its inhibition by various means and by the synthetic dipeptide PCA-His-OMe,” Hormones 2: 193–203, 1971.

    Article  PubMed  CAS  Google Scholar 

  52. Rivier, C., and W. Vale, “In vivo stimulation of prolactin secretion in the rat by thyrotropin releasing factor and related peptides and hypothalamic extracts,” Endocrinology 95: 978–983, 1974.

    Article  PubMed  CAS  Google Scholar 

  53. Grant, G., W. Vale, and R. Guillemin, “Characteristics of the pituitary binding sites for thyrotropin-releasing factor,” Endocrinology 92: 1629–1633, 1973.

    Article  PubMed  CAS  Google Scholar 

  54. Prange, A., “Modification of pentobarbital effects by natural and synthetic polypeptides: Dissociation of brain and pituitary effects,” Life Sci 16: 1907–1914, 1975.

    Article  PubMed  CAS  Google Scholar 

  55. Veber, D.F., F.H. Holly, S.L. Varga, R. Hirschmann, R.F. Nutt, V.J. Lotti, and C.C. Porter, “The dissociation of hormonal and CNS effects in analogues of THR,” Peptides 1976, A. Loffet (ed.), Editions de l’Université de Bruxelles, Brussels, 1976, pp. 453–462.

    Google Scholar 

  56. Burt, D., and S. Snyder, “Thyrotropin releasing hormone (TRH): Apparent receptor binding in rat brain membranes,” Brain Res 93: 309–328, 1975.

    Article  PubMed  CAS  Google Scholar 

  57. Vale, W., P. Brazeau, C. Rivier, M. Brown, B. Boss, J. Rivier, R. Burgus, N. Ling, and R. Guillemin, “Somatostatin,” Recent Prog Horm Res 31: 365–397, 1975.

    PubMed  CAS  Google Scholar 

  58. Rivier, J., P. Brazeau, W. Vale, and R. Guillemin, “Somatostatin analogs: Relative importance of the disulfide bridge and of the Ala-Gly side chain for biological activity,” J. Med Chem 18: 123–126, 1975.

    Article  PubMed  CAS  Google Scholar 

  59. Veber, D., R. Strachan, S. Bergstrand, F. Holly, C. Homnick, R. Hirschmann, M. Torchiana, and R. Saperstein, “Nonreducible cyclic analogues of somatostatin,” J. Am Chem Soc 98: 2367–2369, 1976.

    Article  CAS  Google Scholar 

  60. Sarantakis, D., J. Teichman, E.L. Lien, and R.L. Fenichel, “A novel cyclic undecapeptide WY-40,770, with prolonged growth hormone release inhibiting activity,” Biochem Biophys Res Commun 73: 336–342, 1976.

    Article  PubMed  CAS  Google Scholar 

  61. Garsky, V., D. Clark, and N. Grant, “Synthesis of a nonreducible cyclic analog of somatostatin having only growth hormone release inhibiting activity,” Biochem Biophys Res Commun 73: 911–916, 1976.

    Article  PubMed  CAS  Google Scholar 

  62. Vale, W., P. Brazea, C. Rivier, J. Rivier, and R. Guillemin, “Biological studies with somatostatin,” Advances in Growth Hormone Research, National Institute of Health, Washington, D.C., 1973, pp. 159–182.

    Google Scholar 

  63. Rivier, J., M. Brown, C. Rivier, N. Ling, and W. Vale, “Hypothalamic hypophysiotropic hormones,” Peptides 1976, A. Loffet (ed.), Editions de l’Université de Bruxelles, Brussels, 1976, pp. 427–452.

    Google Scholar 

  64. Rivier, J., M. Brown, and W. Vale, “Tyrosylated analogs of somatostatin,” J. Med Chem 19: 1010–1013, 1976.

    Article  PubMed  CAS  Google Scholar 

  65. Arimura, A., H. Sato, D. Coy, and A. Schally, “Radioimmunoassay for GH-release inhibiting hormone,” Proc Soc Exp Biol Med 148: 784–789, 1975.

    PubMed  CAS  Google Scholar 

  66. Patel, Y., G. Weir, and S. Reichlin, “Anatomic distribution of somatostatin (SRIF) in brain and pancreatic islets as studied by radioimmunoassay,” Endocrinology 96: A154, 1975.

    Google Scholar 

  67. Vale, W., N. Ling, C. Rivier, J. Rivier, J. Villarrea, and M. Brown, “Anatomic and phylogenetic distribution of somatostatin,” Metabolism 25: 1491–1494, 1976.

    Article  PubMed  CAS  Google Scholar 

  68. Brown, M., J. Rivier, and W. Vale, “Biological activity of somatostatin and somatostatin analogs on inhibition of arginine-induced insulin and glucagon release in the rat,” Endocrinology 98: 336–343, 1976.

    Article  PubMed  CAS  Google Scholar 

  69. Holladay, L., and D. Puett, “Physicochemical characteristics and a proposed conformation of somatostatin,” Peptides: Chemistry, Structure and Biology, R. Walter and J. Meienhoffer (eds.), Ann Arbor Science, Ann Arbor, Michigan, 1975, pp. 175–179.

    Google Scholar 

  70. Rivier, J., M. Brown, and W. Vale, “D-Trp8-somatostatin more potent than the native molecule,” Biochem Biophys Res Commun 65: 746–751, 1975.

    Article  PubMed  CAS  Google Scholar 

  71. Marks, N., and F. Stern, “Inactivation of somatostatin (GH-RIH) and its analogs by crude and partially purified rat brain extracts,” FEBS Lett 55: 220–224, 1975.

    Article  PubMed  CAS  Google Scholar 

  72. Gerich, J.E., M.A. Charles, S.R. Levin, P.H. Forsham, and G.H. Grodsky, “In vitro inhibition of pancreatic glucagon secretion by dephenylhydantoin,” J. Clin Endocrinol Metab 35: 823–824, 1972.

    Article  PubMed  CAS  Google Scholar 

  73. Petrack, B., A.J. Czernik, W. Itterly, J. Ansell, and H. Chertock, “On the suppression of insulin and glucagon release by diphenylhydantoin,” Diabetes (suppl 1) 25: 380, 1976.

    Google Scholar 

  74. Petrack, B., A.J. Czernik, W. Itterly, J. Ansell, and H. Chertock, “Diazepam: In vitro effects on glucagon and insulin release,” Biochem Biophys Res Commun 73: 934–939, 1976.

    Article  PubMed  CAS  Google Scholar 

  75. Sarantakis, D., W. McKinley, I. Jaunakais, D. Clark, and N. Grant, “Structure activity studies on somatostatin,” Clin Endocrinol 5: 275–278, 1976.

    Article  Google Scholar 

  76. Brown, M., J. Rivier, and W. Vale, “Somatostatin analogs with dissociated biological activities,” Fed Proc 35: 782, 1976 (Abstract no. 3171).

    Google Scholar 

  77. Brown, M., J. Rivier, and W. Vale, “Somatostatin analogs with selected biological activities,” Science, 1977 (in press).

    Google Scholar 

  78. Vale, W., P. Brazeau, G. Grant, A. Nussey, R. Burgus, J. Rivier, N. Ling, and R. Guillemin, “Culture of enzymatic enzymatically dispersed anterior pituitary cells: Functional validation of a method,” Endocrinology 91: 562–572, 1972.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Laboratories for Neuroendocrinology, The Salk Institute of Biological Studies, La Jolla, California, 92037, USA

    Wylie Vale, Catherine Rivier, Marvin Brown & Jean Rivier

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  1. Wylie Vale
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  2. Catherine Rivier
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  1. University of Texas Health Science Center at Dallas, USA

    John C. Porter

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© 1977 Plenum Press, New York

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Vale, W., Rivier, C., Brown, M., Rivier, J. (1977). Pharmacology of Thyrotropin Releasing Factor (TRF), Luteinizing Hormone Releasing Factor (LRF), and Somatostatin. In: Porter, J.C. (eds) Hypothalamic Peptide Hormones and Pituitary Regulation. Advances in Experimental Medicine and Biology, vol 87. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-8849-8_7

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  • DOI: https://doi.org/10.1007/978-1-4615-8849-8_7

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