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Effect of Short Chain Fatty Acids on Calcium Absorption in Humans

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Dietary Fiber in Health and Disease

Abstract

Increased intake of dietary fiber is now being recommended for the prevention and management of chronic diseases. However, dietary fiber can bind with minerals and reduce mineral availability. We hypothesize that although some fibers may bind minerals in the small intestine, fermentation of the fiber in the colon releases the bound minerals which then are absorbed in the presence of the product of fermentation, short chain fatty acid (SCFA). Thus, fermentable fibers may not cause a reduction in mineral availability, but may shift a portion of the mineral absorption from the small intestine to the colon.

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References

  1. Lutz T. Schauer E. Effect of short chain fatty acids on calcium absorption by the rat colon. Expt’l Physiol 1991; 76:615–618.

    CAS  Google Scholar 

  2. Demigne C, Levrat M, Remesy C. Effect of feeding fermentable carbohydrates on cecal concentration of minerals and their fluxes between the cecum and blood plasma hi the rat. J Nutr 1989; 119:1625–1630.

    CAS  Google Scholar 

  3. Amman P, Rizzoli K, Fleish H. Calcium absorption in rat large intestine, in vivo: availability of dietary calcium. Am J Physiol 1986; 25L:G14–G18.

    Google Scholar 

  4. Nellans HN, Goldsmith RS. ТrAnsephithelial calcium transport by rat cecum: high efficiency absorptive site. Am J Physiol 1981; 240:G424–G431.

    CAS  Google Scholar 

  5. Nellans HN, Kimberg DV. Cellular and paracellular calcium transport in rat ileum: effects of dietary calcium. Am J Physiol 1978; 235:Е726-Е737.

    Google Scholar 

  6. Partridge IG. Studies on digestion and absorption in the intestine of growing pigs. 4. Effects of dietary cellulose and sodium levels on mineral absorption. Br J Nut 1978; 39:539–545.

    Article  CAS  Google Scholar 

  7. Petith M, Schedl AD. Divalent cation transport by rat cecuni and colon in calcium and magnesium deficiency. Proc Soc Expt’l Biol Med 1977; 155:225–229.

    CAS  Google Scholar 

  8. Harrison HC, Harrison HE. Calcium transport by rat colon in vitro. Am J Physiol 1969; 217:121–125.

    CAS  Google Scholar 

  9. Cramer CF, Copp RH. Progress and rate of absorption of radiostrontium through intestinal tract of rat. Proc Soc Expt’l Biol Med 1960; 102:514–517.

    Google Scholar 

  10. Sandstrom B, Ceders ad A, Kivisto B, Stenquist B, Anderson A. Retention of zinc and calcium from the human colon. Am J Clin Nutr 1986; 44:501–504.

    CAS  Google Scholar 

  11. Lutz T, Wurmli R, Schauer E. Short chain fatty acids stimulate magnesium absorption by the colon. In: Magenesim - A Relevant Ion, Lasserre B and Durlach J eds. John Libbey and Company Lts., London England, 1991.

    Google Scholar 

  12. Trinidad TP, Wolever TMS, Thompson LU. Availability of calcium for absorption in the small intestine and colon from diets containing available and unavailable carbohydrates: an in vitro assessment. Int J Food Sci and Nutr 1996; 47:83–88.

    Article  CAS  Google Scholar 

  13. Thompson LU, Trinidad TP, Jenkins DJA. Methods for determining minerals available for absorption in the small intestine and colon. Trace Elements in Man and Animals 1991, 7:25–11–25–12.

    Google Scholar 

  14. Blackeborn DH, Hirsch J, Ahrens EH Jr. Transintestinal intubation: technique for measurement of gut length and physiologic sampling at known loci. Proc Exp Biot Med 1955; 88:356–362.

    Google Scholar 

  15. Schiller LR, Santa Ana CA, Morawski SG, Fordtran JS. Effect of amiloride on Na transport in the proximal, distal and entire human colon in vivo. Dig Dis Sci 1988; 33(8):969–976.

    Article  CAS  Google Scholar 

  16. Williams PL amd Warwick R eds. Gray’s Anatomy. 36th ed., New York. 1985;1354–1358.

    Google Scholar 

  17. Trinidad TP, Wolever TMS, Thompson LU. Interactive effects of calcium and short chain fatty acids on absorption in the distal colon of man. Nutr Res 1993; 13:417–425.

    Article  CAS  Google Scholar 

  18. Trinidad TP, Wolever TMS, Thompson LU. The effect of acetate and propionate on calcium absorption in the rectum and distal colon of man. Am J Clin Nutr, 1996, 63:574–578.

    CAS  Google Scholar 

  19. Cummings JH. Short chain fatty acids in the human colon. Gut 1981; 22:763–779.

    Article  CAS  Google Scholar 

  20. Engelhardt W von and Rechkemmer G. The physiological effects of short chain fatty acids in the hind gut. ln:Fibre in Human and Animal Nutrition, Wallace G and Bells eds., R Soc New Zealand, Wellington, New Zealand. 1983; 20:145–155.

    Google Scholar 

  21. Fleming SE, Choi SY, Fitch MD. Absorption of short chain fatty acids from rat cecum in vivo. J Nutr 1991; 121:1787–1797.

    CAS  Google Scholar 

  22. Rechkemmer G and Engelhardt W von. Concentrations and pH dependence of short chain fatty acids absorption in the proxinal and distal colon of guinea pigs (Cavia procellus). Comp Biochem Physiol 1988; 91A:659–663.

    Article  CAS  Google Scholar 

  23. Nancollas GH. Thermodynamics of ion association. Part II. Alkaline earth acetates and formates. J Chem Soc 1956;744–749.

    Google Scholar 

  24. Lipkin M, Newmark H. Effect of added dietary calcium on colonic epithelial cell proliferation in subjects at high risk for familial colonic cancer. N Eng J Med 1985; 313:1381–1386.

    Article  CAS  Google Scholar 

  25. Berger D. Weissman G, Bronzo R. Effect of calcium citrate on colonic epithelial cell proliferation and DNA content in patient with ulcerative colitis. Gastroenterol 1991; 100:А439.

    Google Scholar 

  26. Lewis LH. Dietary factors - vitamins and minerals. In: Cancer of the Colon, Rectum and Anus, AM Cohen and SJ Winawer eds, McGraww-Hill, New York, 1995:41–49.

    Google Scholar 

  27. Campbell AK. Symposium on intracellular calcium in the control of metabolism. Proc Nutr Soc 1990, 49:51–56.

    Article  CAS  Google Scholar 

  28. Nordin BEC. Calium in Human Biology. London:Springer:Verlag 1988, p.680.

    Book  Google Scholar 

  29. Wargovich MJ, Wong VWS, Newmark H. Calcium inhibits the damaging and compensatory proliferative effect of fatty acids on mouse colon epithelium. Cancer Lett 1984; 23:253–258.

    Article  CAS  Google Scholar 

  30. Bird R, Bruce W. Effect of dietary calcium in toxicity of bile acid and orally administered fat to colonic epithlium. In: Dietary Fat and Cancer, C Ip, D Birt, A Rogers and C Mettlin eds, Alan R. Liss, New York, 1986.

    Google Scholar 

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Trinidad, T.P., Wolever, T.M.S., Thompson, L.U. (1997). Effect of Short Chain Fatty Acids on Calcium Absorption in Humans. In: Kritchevsky, D., Bonfield, C. (eds) Dietary Fiber in Health and Disease. Advances in Experimental Medicine and Biology, vol 427. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5967-2_19

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  • DOI: https://doi.org/10.1007/978-1-4615-5967-2_19

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7735-1

  • Online ISBN: 978-1-4615-5967-2

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