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The Regulation of Sequential Processing of HIV-1 Gag by the Viral Protease

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Aspartic Proteinases

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 436))

Abstract

A full understanding of the structure-function relationship of the retroviral aspartic proteinase (PR) requires a consideration of the role of PR in the biology of the virus. Very little is known about the mechanisms involved in the maturation of the retroviral particle. Viral maturation undoubtedly is a complex process since several thousand copies of the individual components that comprise the virion are generated by the action of PR on the polyprotein precursors, and these components must be sorted and properly assembled to form the mature, infectious virion. Recent studies suggest that cleavage of HIV-1 Gag at its processing sites occurs in an ordered or sequential manner, and that this sequential processing is a regulated event. Taken together, these results support a model in which ordered proteolytic processing of the Gag precursor is an integral part of the regulation and control of virion maturation.

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Authors and Affiliations

  1. Lineberger Comprehensive Cancer Center, USA

    Steve C. Pettit & Ronald Swanstrom

  2. DuPont Merck Pharmaceutical Co., Molecular Biology Department, Wilmington, Delaware, 19880, USA

    Nijing Sheng, Radonna Tritch & Susan Erickson-Viitanen

  3. Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, USA

    Ronald Swanstrom

Authors
  1. Steve C. Pettit
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  2. Nijing Sheng
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  3. Radonna Tritch
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  4. Susan Erickson-Viitanen
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  5. Ronald Swanstrom
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Editors and Affiliations

  1. University of Alberta, Edmonton, Alberta, Canada

    Michael N. G. James

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© 1998 Springer Science+Business Media New York

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Pettit, S.C., Sheng, N., Tritch, R., Erickson-Viitanen, S., Swanstrom, R. (1998). The Regulation of Sequential Processing of HIV-1 Gag by the Viral Protease. In: James, M.N.G. (eds) Aspartic Proteinases. Advances in Experimental Medicine and Biology, vol 436. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5373-1_2

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  • DOI: https://doi.org/10.1007/978-1-4615-5373-1_2

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7452-7

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