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Viral and Host Determinants of Neurovirulence of HIV-1 Infection

  • Chapter
Drugs of Abuse, Immunomodulation, and Aids

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 437))

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Abstract

HIV-1 infection of the brain is often associated with impairment in cognition, motor performance, and behavior in adults, and in addition, slowed milestones of brain growth and development in children(33,42,79). These may range in severity from subtle, mild deficits to conspicuous decline in performance diagnosed as HIV-1 associated dementia (HAD) and may occur in about 25% of AIDS patients independently of opportunistic infections, neoplasms, or metabolic derangements(44,85,104,120). However, close correlations between the clinical course of HAD and laboratory findings are not yet established(43,l40).

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Authors and Affiliations

  1. Dept. of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, 1800 NW 10th Ave., Miami, FL, 33136, USA

    R. K. Fujimura

  2. University of Miami School of Medicine, Miami, Florida, USA

    P. Shapshak, D. M. Segal, K. Goodkin, J. B. Page, R. Douyon, B. T. Zhang & P. Rodriguez de la Vega

  3. Brigham Young University, Provo, Utah, USA

    K. A. Crandall

  4. Jichi Medical School, Minamikawachi-Machi, Tochigi Pre, Japan

    K. Q. Xin

  5. Tohoku University School of Medicine, Sendai, Japan

    I. Nagano

  6. Walter Reed Army Institute for Research, Washington, DC, USA

    A. Srivastava

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  1. University of South Florida College of Medicine, Tampa, Florida, USA

    Herman Friedman  & Thomas W. Klein  & 

  2. Emory University, Atlanta, Georgia, USA

    John J. Madden

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Fujimura, R.K. et al. (1998). Viral and Host Determinants of Neurovirulence of HIV-1 Infection. In: Friedman, H., Madden, J.J., Klein, T.W. (eds) Drugs of Abuse, Immunomodulation, and Aids. Advances in Experimental Medicine and Biology, vol 437. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5347-2_27

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