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Modulation of DPK Cell Function by the Kappa Opioid Agonist U50,488H

  • Chapter
Drugs of Abuse, Immunomodulation, and Aids

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 437))

Abstract

A large body of evidence has been reported that has shown that opioid compounds modulate the function of the immune system. It is apparent, moreover, that both endogenous and exogenous opioid compounds exert immunomodulatory activity. It is well established that opioid administration leads to altered antibody responses,1–7 delayed-type hypersensitivity responses,8–10 and natural killer cell activity.11–14 The mechanism of this immunomodulation is uncertain and may be due to an interaction of the opioid compound with multiple populations of immune cells. Macrophage and T cell functions can be altered following treatment with opioid compounds, and this includes changes in macro- phage microbicidal and tumoricidal activity,15–17 macrophage phagocytic activity,18–22 and the production of the T cell products IL-2, IL-4, and IFN-γ.23–27

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References

  1. Johnson, H.M., Smith, E.M., Torres, B.A. and Blalock, J.E.: Regulation of the in vitro antibody response by neuroendocrine hormones. Proc. Natl. Acad. Sci. USA 79, 4171–4174, 1982.

    Article  PubMed  CAS  Google Scholar 

  2. Heijnen, C.J., Bevers, C., Kavelaars, A. and Ballieux, R.E.: Effect of a-endorphin on the antigen-induced primary antibody response of human blood B cells in vitro. J. Immunol. 136, 213–216, 1986.

    PubMed  CAS  Google Scholar 

  3. Eisenstein, T.K., Meissler, J.J., Jr., Geller, E.B. and Adler, M.W.: immunosuppression to tetanus toxoid induced by implanted morphine pellets. In: M.S. O’Dorisio and A. Panerai (Eds.), Neuropeptides and Immunopeptides: Messengers in a Neuroimmune Axis. New York Academy of Sciences, New York, pp. 377–379, 1990.

    Google Scholar 

  4. Taub, D.D., Eisenstein, T.K., Geller, E.B., Adler, M.W. and Rogers, T.J.: Immunomodulatory activity of μ-and κ-selective opioid agonists. Proc. Natl. Acad. Sci. USA 88, 360–364, 1991.

    Article  PubMed  CAS  Google Scholar 

  5. Bussiere, J.L., Adler, M.W., Rogers, T.J. and Eisenstein, T.K.: Differential effects of morphine and naltrex-one on the antibody response in various mouse strains. Immunopharmacol. Immunotoxicol. 14, 657–673, 1992.

    Article  PubMed  CAS  Google Scholar 

  6. Bussiere, J.L., Adler, M.W., Rogers, T.J. and Eisenstein, T.K.: Effects of in vivo morphine treatment on antibody responses in C57BL/6 bgJ/bgJ (beige) mice. Life Sci. 52, PL43–PL48, 1992.

    Article  Google Scholar 

  7. Bussiere, J.L., Adler, M.W., Rogers, T.J. and Eisenstein, T.K.: Cytokine reversal of morphine-induced suppression of the antibody response. J. Pharmacol. Exp. Ther. 264, 591–597, 1993.

    PubMed  CAS  Google Scholar 

  8. Pellis, N.R., Harper, C. and Dafny, N.: Suppression of the induction of delayed hypersensitivity in rats by repetitive morphine treatments. Exp. Neurol. 93, 92–97, 1986.

    Article  PubMed  CAS  Google Scholar 

  9. Bryant, H.U. and Roudebush, R.E.: Suppressive effects of morphine pellet implants on in vivo parameters of immune function. J. Pharmacol. Exp. Ther. 255, 410–414, 1990.

    PubMed  CAS  Google Scholar 

  10. Molitor, T.W., Morilla, A., Risdahl, J.M., Murtaugh, M.P., Chao, C.C. and Peterson, P.K.: Chronic morphine administration impairs cell-mediated immune responses in swine. J. Pharmacol. Exp. Ther. 260, 581–586, 1992.

    PubMed  CAS  Google Scholar 

  11. Weber, R.J. and Pert, A.: The periaqueductal gray matter mediates opiate-induced immunosuppression. Science 245, 188–190, 1989.

    Article  PubMed  CAS  Google Scholar 

  12. Shavit, Y., Yirmiya, R. and Beilin, B.: Stress neuropeptides, immunity and neoplasia. In: S. Freier (Ed.), The Neuroendocrine-Immune Network, CRC Press, Boca Raton, pp. 163–175, 1990.

    Google Scholar 

  13. Bayer, B.M., Daussin, S., Hernandez, M. and Irvin, L.: Morphine inhibition of lymphocyte activity is mediated by an opioid dependent mechanism. Neuropharmacology 29, 369–374, 1990.

    Article  PubMed  CAS  Google Scholar 

  14. Carr, D.J.J. and France, C.P.: Immune alterations in morphine-treated rhesus monkeys. J. Pharmacol. Exp. Ther. 267, 9–15, 1993.

    PubMed  CAS  Google Scholar 

  15. Tubaro, E., Borelli, G., Croce, C., Cavallo, G. and Santiangeli, C: Effect of morphine on resistance to infection. J. Inf. Dis. 148, 656–666, 1983.

    Article  CAS  Google Scholar 

  16. Tubaro, E., Santiangeli, C., Belogi, L., Borelli, G., Cavallo, G., Croce, E. and Avico, U.: Methadone vs morphine: comparison of their effect on phagocytic functions. Int. J. Immunopharmacol. 9, 79–88, 1987.

    Article  PubMed  CAS  Google Scholar 

  17. Hagi, K., Uno, K., Inaba, K. and Muramatsu, S.: Augmenting effect of opioid peptides on murine macrophage activation. J. Neuroimmunol. 50, 71–76, 1994.

    Article  PubMed  CAS  Google Scholar 

  18. Foris, G., Medgyesi, A., Gyimesi, E. and Hauck, M.: Met-enkephalin induced alterations of macrophage functions. Molec. Immunol. 21, 747–750, 1984.

    Article  CAS  Google Scholar 

  19. Foris, G., Medgyesi, G.A. and Hauk, M.: Bidirectional effect of met-enkephalin on macrophage effector functions. Mol. Cell. Biochem. 69, 127–137, 1986.

    Article  PubMed  CAS  Google Scholar 

  20. Casellas, A.M., Guardiola, H. and Renaud, F.L.: Inhibition by opioids of phagocytosis in peritoneal macrophages. europeptides 18, 35–40, 1991.

    Article  CAS  Google Scholar 

  21. Rojavin, M., Szabo, I., Bussiere, J.L., Rogers, T.J., Adler, M.W. and Eisenstein, T.K.: Morphine treatment in vitro or in vivo decreases phagocytic functions of murine macrophages. Life Sci. 53, 997–1006, 1993.

    Article  PubMed  CAS  Google Scholar 

  22. Szabo, I., Rojavin, M., Bussiere, J.L., Eisenstein, T.K., Adler, M.W. and Rogers, T.J.: Suppression of peritoneal acrophage phagocytosis of Candida albicans by opioids. J. Pharmacol. Exp. Ther. 267, 703–706, 1993.

    PubMed  CAS  Google Scholar 

  23. Brown, S.L. and Van Epps, D.E.: Opioid peptides modulate production of interferon-gamma by human mononuclear cells. Cell. Immunol. 103, 19–26, 1986.

    Article  PubMed  CAS  Google Scholar 

  24. Peterson, P.K., Sharp, B., Gekker, G., Brummitt, C. and Keane, W.F.: Opioid-mediated suppression of interferon-γ production by cultured peripheral blood mononuclear cells. J. Clin. Invest. 80, 824–831, 1987.

    Article  PubMed  CAS  Google Scholar 

  25. Bessler, H., Sztein, M.B. and Serrate, S.A.: β-Endorphin modulation of IL-1-induced IL-2 production. Immunopharmacology 19, 5–14, 1990.

    Article  PubMed  CAS  Google Scholar 

  26. van den Bergh, P., Rozing, J. and Nagelkerken, L.: β-Endorphin stimulates la expression on mouse B cells by inducing interleukin-4 secretion by CD4+ T cells. Cell. Immunol. 149, 180–192, 1993.

    Article  PubMed  Google Scholar 

  27. van den Bergh, P., Dobber, R., Ramlal, S., Rozing, J. and Nagelkerken, L.: Role of opioid peptides in the regulation of cytokine production by murine CD4+ T cells. Cell. Immunol. 154, 109–122, 1994.

    Article  PubMed  Google Scholar 

  28. Belkowski, S.M., Zhu, J., Liu-Chen, L.-Y., Eisenstein, T.K., Adler, M.W. and Rogers, T.J.: Sequence of κ-opioid receptor cDNA in the Rl.l thymoma cell line. J. Neuroimmunol. 62, 113–117, 1995.

    Article  PubMed  CAS  Google Scholar 

  29. Bidlack, J.M., Saripalli, L.D. and Lawrence, D.M.P.: κ-Opioid binding sites on a murine lymphoma cell line. Eur. J. Pharmacol. 227, 257–265, 1992.

    Article  PubMed  CAS  Google Scholar 

  30. Lawrence, D.M.P. and Bidlack, J.M.: Kappa opioid binding sites on the Rl.l murine lymphoma cell line: sensitivity to cations and guanine nucleotides. J. Neuroimmunol. 41, 223–230, 1992.

    Article  PubMed  CAS  Google Scholar 

  31. Lawrence, D.M.P. and Bidlack, J.M.: The kappa opioid receptor expressed on the mouse Rl.l thymoma cell line is coupled to adenylyl cyclase through a pertussis toxin-sensitive guanine nucleotide-binding regulatory rotein. J. Pharmacol. Exp. Ther. 266, 1678–1683, 1993.

    PubMed  CAS  Google Scholar 

  32. Yasuda, K., Raynor, K., Kong, H., Breder, CD., Takeda, J., Reisine, T. and Bell, G.I.: Cloning and functional comparison of κ-and δ-opioid receptors from mouse brain. Proc. Natl. Acad. Sci. USA 90, 6736–6740, 1993.

    Article  PubMed  CAS  Google Scholar 

  33. Kaye, J., and Ellenberger, D.: Differentiation of an immature T cell line: a model of thymic positive selection. Cell 71, 423–435, 1992.

    Article  PubMed  CAS  Google Scholar 

  34. Chuang, L.F., Chuang, T.K., Killam, K.F.J., Chuang, A.J., Kung, H., Yu, L. and Chuang, R.Y: Delta opioid receptor gene expression in lymphocytes. Biochem. Biophys. Res. Commun. 202, 1291–1299, 1994.

    Article  PubMed  CAS  Google Scholar 

  35. Sedqi, M., Roy, S., Ramakrishnan, S., Eide, R. and Loh, H.H.: Complementary DNA cloning of a μ.-opioid receptor from rat peritoneal macrophages. Biochem. Biophys. Res. Commun. 209, 563–574, 1995.

    Article  PubMed  CAS  Google Scholar 

  36. Chuang, L.F., Chuang, T.K., Killam, K.F., Qiu, Q., Wang, X.R., Lin, J.-J., Kung, H.-E, Sheng, W., Chao, C, Yu, L. and Chuang, R.Y.: Expression of kappa opioid receptors in human and monkey lymphocytes. Biochem. Biophys. Res. Commun. 209, 1003–1010, 1995.

    Article  PubMed  CAS  Google Scholar 

  37. Kisielow, P. and Von Boehmer, H.: Development and selection of T cells: Facts and puzzles. Adv. Immunol. 58, 87–209, 1995.

    Article  PubMed  CAS  Google Scholar 

  38. Belkowski, S.M., Zhu, J., Liu-Chen, L.Y., Eisenstein, T.K., Adler, M.W. and Rogers, T.J.: Detection of κ-opioid receptor mRNA in immature T cells. Adv. Exp. Med. Biol. 373, 11–16, 1995.

    Article  PubMed  CAS  Google Scholar 

  39. Guan, L., Eisenstein, T.K., Adler, M.W. and Rogers, T.J.: Inhibition of T cell superantigen responses following reatment with the κ-opioid agonist U50,488H. J. Neuroimmunol. 75, 163–168, 1997.

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Microbiology and Immunology, Temple University School of Medicine, Philadelphia, Pennsylvania, 19140, USA

    Liming Guan, Toby K. Eisenstein & Thomas J. Rogers

  2. Department of Pharmacology, Temple University School of Medicine, Philadelphia, Pennsylvania, 19140, USA

    Martin W. Adler

  3. Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania, 19140, USA

    Thomas J. Rogers

Authors
  1. Liming Guan
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  2. Toby K. Eisenstein
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  3. Martin W. Adler
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  4. Thomas J. Rogers
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Editor information

Editors and Affiliations

  1. University of South Florida College of Medicine, Tampa, Florida, USA

    Herman Friedman  & Thomas W. Klein  & 

  2. Emory University, Atlanta, Georgia, USA

    John J. Madden

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© 1998 Springer Science+Business Media New York

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Guan, L., Eisenstein, T.K., Adler, M.W., Rogers, T.J. (1998). Modulation of DPK Cell Function by the Kappa Opioid Agonist U50,488H. In: Friedman, H., Madden, J.J., Klein, T.W. (eds) Drugs of Abuse, Immunomodulation, and Aids. Advances in Experimental Medicine and Biology, vol 437. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5347-2_14

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  • DOI: https://doi.org/10.1007/978-1-4615-5347-2_14

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7439-8

  • Online ISBN: 978-1-4615-5347-2

  • eBook Packages: Springer Book Archive

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