Abstract
Spleen cells cultured from Balb/c mice immunized with the JHM strain of mouse hepatitis virus (JHMV) have CD8+cytotoxic T cells (CTL) specific for both the S and N proteins, but not the M or HE proteins. T cell lines were established from the brains of Balb/c mice infected with JHMV. The majority of the lines (20 of 22) were specific for JHMV. Analysis of the viral structural proteins which served as target structures indicate that most (15 of 20) were specific for the N protein. One line was specific for the S protein and four lines were specific for JHMV but the protein recognized could not be determined. These data suggest that early during infection there is a preferential recruitment of N protein specific CTL into the CNS of infected mice.
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References
Kyuwa, S. and S.A. Stohlman. Seminar Virol. 1:273–280, (1990).
Sussman, M., Shubin, R., Kyuwa, S. and S.A. Stohlman. J. Virol. 63:3051–3059, (1989).
Yamaguchi, K. Goto, N. Kyuwa, S., Hayami, M. and Y. Toyoda. J. Neuroimmunol. 32:1–9, (1991).
Williamson, J.S.-P., Sykes, K. and S., Stohlman. J. Neuroimmunol. 32:199–207, (1991).
Stohlman, S.A., P.R. Brayton, J.O. Fleming, L.P. Weiner, and M.M.-C. Lai. J. Gen. Virol. 63:265–275, (1982)
Yokomori, K., La Monica, N., Makino, S., Shieh, C.-K., and Lai, M.M.C. Virol. 173:683–691, (1989).
Stohlman, S., Cohen, M., Kyuwa,S. Bergmann,C., Anthony,R. and J.G.,Keck. 1992. Virol. 189:217–224, (1992).
Lampson, L.A. Trends in Neurosci. 10:211–216, (1987).
Fleming, J.O., Trousdale, M.D., Bradbury, J., Stohlman, S.A. and L.P. Weiner. Microbiol. Pathogen. 3:9–20, (1987).
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© 1994 Springer Science+Business Media New York
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Stohlman, S., Bergmann, C., LaMonica, N., Lai, M., Yeh, J., Kyuwa, S. (1994). JHM Virus-Specific Cytotoxic T Cells Derived from the Central Nervous System. In: Laude, H., Vautherot, JF. (eds) Coronaviruses. Advances in Experimental Medicine and Biology, vol 342. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2996-5_66
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DOI: https://doi.org/10.1007/978-1-4615-2996-5_66
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