Abstract
Raising the concentration of arterial plasma potassium ([K+]a) to levels seen in heavy exercise in man (7–8mM)1–2 excites the arterial chemoreceptors of the anaesthetised cat3 4 and causes an increase in ventilation5. The excitation of chemoreceptor discharge by hyperkalaemia is further enhanced by hypoxia and virtually abolished with short latency by abruptly replacing the inspiratory gas with oxygen6. Furthermore the stimulatory effects of potassium are abolished by peripheral chemoreceptor denervation5. We show here that ventilation in the decerebrate cat and sedated rhesus monkey is increased during hyperkalaemia and that this effect is also virtually abolished by abrupt replacement of inspired gas with 100% oxygen.
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© 1993 Springer Science+Business Media New York
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Paterson, D.J., Nye, P.C.G. (1993). Effects of Oxygen Tests on the Ventilatory Resposes of the cat and Rhesus Monkey to Changes in Arteral Potassium. In: Data, P.G., Acker, H., Lahiri, S. (eds) Neurobiology and Cell Physiology of Chemoreception. Advances in Experimental Medicine and Biology, vol 337. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2966-8_51
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DOI: https://doi.org/10.1007/978-1-4615-2966-8_51
Publisher Name: Springer, Boston, MA
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