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Endoplasmic Reticulum and the Control of Ca2+ Homeostasis

  • Chapter
Endoplasmic Reticulum

Part of the book series: Subcellular Biochemistry ((SCBI,volume 21))

Abstract

Control of Ca2+ homeostasis is one of the fundamental activities of eukaryotic cells. In the extracellular medium the concentration of the free ion is maintained in the millimolar range whereas in the cytosol the resting value is approximately four orders of magnitude lower, yet the total calcium content per cell amounts to several millimoles per liter. This means that most of this calcium is not free, but bound to appropriate molecules and/or segregated within intracellular organelles. At each given time, the distribution of Ca2+ among the segregated, the cytosolic, and the extracellular compartments is the result of a complex, dynamic equilibrium that relies on the coordinated activation of specific pumps, transporters, and channels.

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  1. Department of Pharmacology, CNR Cytopharmacology and B. Ceccarelli Centers, and San Raffaele Institute, University of Milan, Milan, Italy

    Jacopo Meldolesi & Antonello Villa

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  1. Jacopo Meldolesi
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  2. Antonello Villa
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  1. CNR Center for Cytopharmacology, University of Milan, Milan, Italy

    N. Borgese

  2. Institute of Zoology, University of Mainz, Mainz, Germany

    J. R. Harris

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Meldolesi, J., Villa, A. (1993). Endoplasmic Reticulum and the Control of Ca2+ Homeostasis. In: Borgese, N., Harris, J.R. (eds) Endoplasmic Reticulum. Subcellular Biochemistry, vol 21. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2912-5_9

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