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Reflexes Arising from the Arterial Chemoreceptors

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Arterial Chemoreceptors

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 360))

Abstract

This short review gives a general survey of the reflex effects of the excitation of the arterial chemoreceptors. It focuses on responses that increase minute ventilation and those that determine the distribution of blood flow within the cardiovascular system, but also touches on influences that occur alongside these. Particular emphasis is given to discussion of the role of the carotid bodies in the generation of exercise hyperpnoea. More comprehensive coverage of this material may be found in reviews by O’Regan and Majcherczyk (1982), Eyzaguirre et al. (1983), Daly (1984), Fitzgerald & Lahiri (1986), and Cunningham (1987). The role of the carotid body in acclimatization to high altitude is covered by Bisgard’s chapter in this book.

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References

  • Al-Obaidi, M., & Karim, F. (1992). Primary effects of carotid chemoreceptor stimulation on gracilis muscle and renal blood flow and renal function in dogs. J. Physiol. 455:73–88.

    PubMed  CAS  Google Scholar 

  • Alvarez-Buylla, R., &de Alvarez-Buylla, E.R. (1988). Carotid sinus receptors participate in glucose homeostasis. Respir. Physiol. 72:347–359.

    Article  PubMed  CAS  Google Scholar 

  • Asmussen, E., &Nielsen, M. (1946). Studies on the regulation of respiration in heavy work. Acta Physiol. Scand. 12:171–188.

    Article  Google Scholar 

  • Attinger, F.M., Attinger, E.O., Cooperson, D., &Gottschalk, W. (1976). Interactions between carotid sinus mechanoreceptor and chemoreceptor reflex loops. Pflugers Arch. 363:255–261.

    Article  PubMed  CAS  Google Scholar 

  • Band, D.M., Linton, R.A.F., Kent, R., &Kurer, F.L. (1985). The effect of peripheral chemodenervation on the ventilatory response to potassium. Respir. Physiol. 60:217–225.

    Article  PubMed  CAS  Google Scholar 

  • Berkenbosch, A., Heeringa, J., Olievier, C.N., &Kruyt, E.W. (1979a). Artificial perfusion of the ponto-medullary region of cats. A method for separation of central and peripheral effects of chemical stimulation of ventilation. Respir. Physiol. 37:347–364.

    Article  PubMed  CAS  Google Scholar 

  • Berkenbosch, A., Van Dissel, J., Olievier, C.N., DeGoede, J., &Heeringa, J. (1979b). The contribution of the peripheral chemoreceptors to the ventilatory response to CO2 in anaesthetized cats during hyperoxia. Respir. Physiol. 37:381–390.

    Article  PubMed  CAS  Google Scholar 

  • Berkenbosch, A., Van Beek, J.H.G.M., Olievier, C.N., DeGoede, J., &Quanjer, P.H.H. (1984). Central respiratory CO2 sensitivity at extreme hypocapnia. Respir. Physiol. 55:95–102.

    Article  PubMed  CAS  Google Scholar 

  • Bishop, B. (1974). Carotid baroreceptor modulation of diaphragm and abdominal muscle activity in the cat. J.Appl. Physiol. 36:12–19.

    PubMed  CAS  Google Scholar 

  • Black, A.M.S., &Torrance, R.W. (1971). Respiratory oscillations in chemoreceptor discharge in the control of breathing. Respir. Physiol. 13:221–237.

    Article  PubMed  CAS  Google Scholar 

  • Burger, R.E., Estavillo, J.A., Kumar, P., Nye, P.C.G., &Paterson, D.J. (1988). Effects of potassium, oxygen and carbon dioxide on the steady-state discharge of cat carotid body chemoreceptors. J. Physiol. 401:519–531.

    PubMed  CAS  Google Scholar 

  • Busse, M.W., Maassen, N., &Konrad, H. (1991). Relation between plasma K+ and ventilation during incremental exercise after glycogen depletion and repletion in man. J. Physiol. 443:469–476.

    PubMed  CAS  Google Scholar 

  • Cardenas, H., &Zapata, P. (1983). Ventilatory reflexes originated from carotid and extracarotid chemoreceptors in rats. Am. J. Physiol. 244:R119–R125.

    PubMed  CAS  Google Scholar 

  • Comroe, J.H., &Mortimer, L. (1965). The respiratory and cardiovascular responses of temporally separated aortic and carotid bodies to cyanide, nicotine, phenyldiguanide and serotonin. J. Pharmac. Exp. Ther. 146:33–41.

    Google Scholar 

  • Cunningham, D.J.C. (1975). A model illustrating the importance of timing in the regulation of breathing. Nature. 253:440–442.

    Article  PubMed  CAS  Google Scholar 

  • Cunningham, D.J.C. (1987). Studies on arterial chemoreceptors in man. J. Physiol. 384:1–26.

    PubMed  CAS  Google Scholar 

  • Cunningham, D.J.C., Hey, E.N., Patrick, J.M., &Lloyd, B.B. (1963). The effect of noradrenaline infusion on the relation between pulmonary ventilation and the alveolar PO2 and PCO2 in man. Ann. NY Acad. Sci. 109:756–771.

    Article  PubMed  CAS  Google Scholar 

  • Cunningham, D.J.C., Lloyd, B.B., &Spurr, D. (1966). Doubts about the ‘anaerobic work substance’ as a stimulus to breathing in exercise. J. Physiol. 186:110–111.

    Google Scholar 

  • Cunningham, D.J.C., Spurr, D., &Lloyd, B.B. (1968). The drive to ventilation from arterial chemoreceptors in hypoxic exercise. In “Arterial Chemoreceptors.” R.W. Torrance, ed.. Blackwell, Oxford pp. 301–323.

    Google Scholar 

  • Daly, M.deB. (1984). Breath-hold diving: mechanisms of cardiovascular adjustments in the mammal. In “Recent Advances in Physiology.” vol 10. P.F. Baker., ed., Churchill Livingstone, pp. 201–245.

    Google Scholar 

  • Daly, M.deB. (1991). Some reflex cardioinhibitory responses in the cat and their modulation by central inspiratory neuronal activity. J. Physiol. 439:559–577.

    PubMed  CAS  Google Scholar 

  • Daly, M.deB., &Ungar, A. (1966). Comparison of the reflex responses elicited by stimulation of the separately perfused carotid and aortic body chemoreceptors in the dog. J. Physiol. 182:379–403.

    PubMed  CAS  Google Scholar 

  • Daly, M.deB., Korner, P.I., Angell James, J.E., &Oliver, J.R. (1978). Cardiovascular-respiratory reflex interactions between carotid bodies and upper-airways receptors in the monkey. Am. J. Physiol. 234:H293–H299.

    PubMed  CAS  Google Scholar 

  • Daly, M.deB., Ward, J., &Wood, L.M. (1986). Modification by lung inflation of the vascular responses from the carotid body chemoreceptors and other receptors in dogs. J. Physiol. 378:13–30.

    PubMed  CAS  Google Scholar 

  • Daly, M.deB., &Kirkman, E. (1989). Differential modulation by pulmonary stretch afferents of some reflex cardioinhibitory responses in the cat. J. Physiol. 417:323–341.

    PubMed  CAS  Google Scholar 

  • Davis, B., Chinn, R., Gold, J., Popovac, D., Widdicombe, J.G., &Nadel, J.A. (1982). Hypoxemia reflexly increases secretion from tracheal submucosal glands in dogs. J. Appl. Physiol. 52:1416–1419.

    PubMed  CAS  Google Scholar 

  • DeGoede, J., Berkenbosch, A., Olievier, C.N. &Quanjer, P.H.H. (1981). Ventilatory response to carbon dioxide and apnoeic thresholds. Respir. Physiol. 45:185–199.

    Article  CAS  Google Scholar 

  • Dejours, P. (1962). Chemoreflexes inbreathing. Physiol. Rev. 42:335–358.

    PubMed  CAS  Google Scholar 

  • Denjean, A., Canet, E., Praud, J.P., Gaultier, C., Bureau, M., &Gagne, B. (1991). Hypoxia-induced bronchial responsiveness in awake sheep: Role of carotid chemoreceptors. Respir. Physiol. 83:201–210.

    Article  PubMed  CAS  Google Scholar 

  • Douglas, C.G., Haldane, J.S., Henderson, Y., &Schneider, E.C. (1913). Physiological observations made on Pike’s Peak, Colorado, with special reference to adaptation to low barometric pressures. Phil. Trans. Roy. Soc. B 203:185–318.

    Article  Google Scholar 

  • Eldridge, F.L. (1972). The importance of timing on the respiratory effects of intermittent carotid body stimulation. J. Physiol. 222:319–333.

    PubMed  CAS  Google Scholar 

  • Eldridge, F.L., Millhorn, D.E., &Waldrop, T.G. (1981). Exercise hyperpnea and locomotion: parallel activation from the hypothalamus. Science. 211:844–846.

    Article  PubMed  CAS  Google Scholar 

  • Eisner, R., Angell James, J.E., &Daly, M.deB. (1977). Carotid body chemoreceptor reflexes and their interactions in the seal. Am. J. Physiol. 232:H517–H525.

    Google Scholar 

  • Eyzaguirre, C., Fitzgerald, R.S., Lahiri, S. &Zapata, P. (1983). Arterial Chemoreceptors. In “Handbook of Physiology. The Cardiovascular System.” vol III. American Physiological Society. Bethesda Maryland, pp.557–621

    Google Scholar 

  • Fitzgerald, R.S., &Parks, D.C. (1971). Effect of hypoxia on carotid chemoreceptor response to carbon dioxide in cats. Respir. Physiol. 12:218–229.

    Article  PubMed  CAS  Google Scholar 

  • Fitzgerald, R.S. &Lahiri, S. (1986). Reflex Responses to Chemoreceptor Stimulation. In “Handbook of Physiology. The Respiratory System.” vol II pt 1. American Physiological Society. Bethesda Maryland, pp.313–362.

    Google Scholar 

  • Forster, H.V., Pan, L.G., Bisgard, G.E., Kaminski, R.P., Dorsey, S.M., &Busch, M.A. (1983). Hyperpnea of exercise at various PIO2 in normal and carotid body-denervated ponies. J. Appl. Physiol. 54:1387–1393.

    PubMed  CAS  Google Scholar 

  • Gallego, R., &Belmonte, C. (1979). The effects of blood osmolality changes on cat carotid body chemoreceptors in vivo. Pflugers Arch. 380:53–58.

    Article  PubMed  CAS  Google Scholar 

  • Gallego, R., Eyzaguirre, C., &Monti-Bloch, L. (1979). Thermal and osmotic responses of arterial receptors. J. Neurophysiol. 42:665–680.

    PubMed  CAS  Google Scholar 

  • Griffiths, T.L., Henson, L.C., &Whipp, B.J. (1986). Influence of inspired oxygen concentration on the dynamics of the exercise hyperpnoea in man. J. Physiol. 380:387–403.

    PubMed  CAS  Google Scholar 

  • Grunstein, M.M., Derenne, J.P. &Milic-Emili, J. (1975). Control of depth and frequency of breathing during baroreceptor stimulation in cats. J. Appl. Physiol. 39:395–404.

    PubMed  CAS  Google Scholar 

  • Guazzi, M., Baccelli, G., &Zanchetti, A. (1968). Reflex chemoceptive regulation of arterial pressure during natural sleep in the cat. Am. J. Physiol. 214:969–978.

    PubMed  CAS  Google Scholar 

  • Hackett, J.G., Abboud, F.M., Mark, A.L., Schmid, P.G., &Heistad, D.D. (1972). Coronary vascular responses to stimulation of chemoreceptors and baroreceptors: evidence for reflex activation of vagal cholinergic innervation. Circ. Res. 31:8–17.

    Article  PubMed  CAS  Google Scholar 

  • Hagberg, J.M., Coyle, E.F., Carroll, J.E., Miller, J.M., Martin, W.H., &Brooke, M.H. (1982). Exercise hyperventilation in patients with McArdle’s disease. J. Appl. Physiol. 52(4):991–994.

    PubMed  CAS  Google Scholar 

  • Hainsworth, R., Karim, F., &Sofola, O.A. (1979). Left ventricular inotropic responses to stimulation of carotid body chemoreceptors in anaesthetized dogs. J. Physiol. 287:455–466.

    PubMed  CAS  Google Scholar 

  • Heeringa, J., Berkenbosch, A., DeGoede, J., &Olievier, C.N. (1979). Relative contribution of central and peripheral chemoreceptors to the ventilatory response to CO2 during hyperoxia. Respir. Physiol. 37:365–379.

    Article  PubMed  CAS  Google Scholar 

  • Heigenhauser, G.J.F., Sutton, J.R., &Jones, N.L. (1983). Effect of glycogen depletion on the ventilatory response to exercise. J. Appl. Physiol. 54(2):470–474.

    PubMed  CAS  Google Scholar 

  • Heistad, D., Abboud, F.M., Mark, A.L., &Schmid, P.G. (1975). Effect of baroreceptor activity on ventilatory response to chemoreceptor stimulation. J. Appl. Physiol. 39:411–416.

    PubMed  CAS  Google Scholar 

  • Honda, Y. (1992). Respiratory and circulatory activities in carotid body-resected humans. J. Appl. Physiol. 73:1–8.

    PubMed  CAS  Google Scholar 

  • Honig, A. (1989). Peripheral arterial chemoreceptors and reflex control of sodium and water homeostasis. Am. J. Physiol. 257:R1282–R1302.

    PubMed  CAS  Google Scholar 

  • Hopp, FA., Seagard, J.L., Bajic, J., &Zuperku, E.J. (1991). Respiratory responses to aortic and carotid chemoreceptor activation in the dog. J. Appl. Physiol. 70:2539–2550.

    PubMed  CAS  Google Scholar 

  • Ito, B.R., &Feigl, E.O. (1985). Carotid chemoreceptor reflex parasympathetic coronary vasodilation in the dog. Am. J. Physiol. 249:H1167–H1175.

    PubMed  CAS  Google Scholar 

  • James, J.E., &Daly, M.deB. (1969). Cardiovascular responses in apnoeic asphyxia: role of arterial chemoreceptors and the modification of their effects by a pulmonary vagal inflation reflex. J. Physiol. 201:87–104.

    PubMed  CAS  Google Scholar 

  • Karim, F., Poucher, S.M., &Summerill, R.A. (1987). The effects of stimulating carotid chemoreceptors on renal haemodynamics and function in dogs. J. Physiol. 392:451–462.

    PubMed  CAS  Google Scholar 

  • Karim, F., &Al-Obaidi, M. (1993). Modification of carotid chemoreceptor-induced changes in renal haemodynamics and function by carotid baroreflex in dogs. J. Physiol. 466:599–610.

    PubMed  CAS  Google Scholar 

  • Lahiri, S., &Delaney, R.G. (1975). Stimulus interaction in the responses of carotid body chemoreceptor single afferent fibres. Resp. Physiol. 24:249–266.

    Article  CAS  Google Scholar 

  • Little, R., &Oberg, B. (1975). Circulatory responses to stimulation of the carotid body chemoreceptors in the cat. Acta Physiol. Scand. 93:34–50.

    Article  PubMed  CAS  Google Scholar 

  • Lloyd, B.B., &Cunningham, D.J.C. (1963). A quantitative approach to the regulation of human respiration. In “The Regulation of Human Respiration.” D.J.C. Cunningham &B.B. Lloyd, eds., Blackwell,Oxford, pp. 331–349.

    Google Scholar 

  • Macleod, J.J.R. (1909). Studies in experimental glycosuria: IV. The cause of hyperglycaemia produced by asphyxia. Am. J. Physiol. 23:278–302.

    Google Scholar 

  • Mancia, G., Shepherd, J.T., &Donald, D.E. (1976). Interplay among carotid sinus, cardiopulmonary, and carotid body reflexes in dogs. Am. J. Physiol. 230:19–24.

    PubMed  CAS  Google Scholar 

  • Marshall, J.M. (1987). Analysis of cardiovascular responses evoked following changes in peripheral chemoreceptor activity in the rat. J. Physiol. 394:393–414.

    PubMed  CAS  Google Scholar 

  • Martin-Body, R.L., Robson, R.J., &Sinclair, J.D. (1985). Respiratory effects of sectioning the carotid sinus glossopharyngeal and abdominal vagal nerves in the awake rat. J. Physiol. 361:35–45.

    PubMed  CAS  Google Scholar 

  • McLoughlin, P., Linton, R.A.F., &Band, D.M. (1992). The effect of intravenous infusions of KCl and lactic acid on ventilation in anaesthetised cats. J. Physiol. 446:426P.

    Google Scholar 

  • Nye, P.C.G., &Painter, R. (1989). Quantifying the steady-state discharge of the carotid body of the anaesthetized cat. J. Physiol. 417:172P.

    Google Scholar 

  • O’Donnell, C.P., &Bower, E.A. (1992). Heart rate changes evoked by hypoxia in the anaesthetized, artificially ventilated cat. Exp. Physiol. 77:271–283.

    CAS  Google Scholar 

  • O’Regan, R.G., &Majcherczyk, S. (1982). Role of peripheral chemoreceptors and central chemosensitivity in the regulation of respiration and circulation. J. Exp. Biol. 100:23–40.

    PubMed  Google Scholar 

  • Paterson, D.J., &Nye, P.C.G. (1988). The effect of beta adrenergic blockade on the carotid body response to hyperkalaemia in the cat. Respir. Physiol. 74:229–238.

    Article  PubMed  CAS  Google Scholar 

  • Paterson, D.J., Robbins, P.A., &Conway, J. (1989). Changes in arterial plasma potassium and ventilation during exercise in man. Respir. Physiol. 78:323–330.

    Article  PubMed  CAS  Google Scholar 

  • Paterson, D.J., Friedland, J.S., Bascom, D.A., Clement, I.D., Cunningham, D. A., Painter, R., &Robbins, P.A. (1990). Changes in arterial K+ and ventilation during exercise in normal subjects and subjects with McArdle’s syndrome. J. Physiol. 429:339–348.

    PubMed  CAS  Google Scholar 

  • Paterson, D.J., &Nye, P.C.G. (1991). Effect of oxygen on potassium-excited ventilation in the.decerebrate cat. Respir. Physiol. 84:223–230.

    Article  PubMed  CAS  Google Scholar 

  • Paterson, D.J., Dorrington, K.L., Bergel, D.H., Kerr, G., Miall, R.C., Stein, J.F., &Nye, P.C.G. (1992). Effect of potassium on ventilation in the rhesus monkey. Exp. Physiol. 77(1):217–220.

    PubMed  CAS  Google Scholar 

  • Perret, C. (1960). Hyperoxie et regulation de la ventilation durant l’exercice musculaire. Helv. Physiol. et Pharmacol. Acta. 18:72–97.

    CAS  Google Scholar 

  • Petersen, E.S., Whipp, B.J., Davis, J.A., Huntsman, D.J., Brown, H.V., &Wasserman, K. (1983). Effects of beta-adrenergic blockade on ventilation and gas exchange during exercise in humans. J. Appl. Physiol. 54:1306–1313.

    PubMed  CAS  Google Scholar 

  • Ponte, J., &Purves, M.J. (1974). The role of the carotid body chemoreceptors and carotid sinus baroreceptors in the control of cerebral blood vessels. J. Physiol. 237:315–340.

    PubMed  CAS  Google Scholar 

  • Qayyum, M.S., Barlow, C.W., Paterson, D.J., &Robbins, P.A. (1993). Increased ventilatory sensitivity to hypoxia with raised arterial potassium concentration at rest and during exercise in man. J. Physiol. (in press).

    Google Scholar 

  • Robbins, P.A. (1989). Design and analysis of experiments for studying hypoxia-hypercapnia interactions in respiratory control. In “Modeling and parameter estimation in respiratory control.” M.C.K. Khoo, ed., Plenum,New York, pp.83–89.

    Chapter  Google Scholar 

  • Shea, S.A., Andres, L.P., Shannon, D.C., &Banzett, R.B. (1993). Ventilatory responses to exercise in humans lacking ventilatory chemosensitivity. J. Physiol. 468:623–640.

    PubMed  CAS  Google Scholar 

  • Stromme, S.B., &Blix, A.S. (1976). Indirect evidence for arterial chemoreceptor reflex facilitation by face immersion in man. Aviat. Space Environ. Med. 47:597–599.

    PubMed  CAS  Google Scholar 

  • Ward, M.P., Milledge, J.S., &West, J.B. (1989). Acute Mountain Sickness. In “High Altitude Medicine and Physiology.” University of Pennsylvania Press, pp. 369–379.

    Google Scholar 

  • Ward, S.A., &Robbins, P.A. (1987). The ventilatory response to hypoxia. In “The Control of Breathing in Man.” B.J. Whipp, ed., Manchester University Press, pp. 29–44.

    Google Scholar 

  • Wasserman, K., Whipp, B.J., Koyal, S.N., &Cleary, M.G. (1975). Effect of carotid body resection on ventilatory and acid-base control during exercise. J. Appl. Physiol. 39:354–358.

    PubMed  CAS  Google Scholar 

  • Weil, J.V., Byrne-Quinn, E., Sodal, I.E., Kline, J.S., McCullough, R.E., &Filley, G.F. (1972). Augmentation of chemosensitivity during mild exercise in normal man. J. Appl. Physiol. 33(6):813–819.

    PubMed  CAS  Google Scholar 

  • Wright, S. (1930). Action of adrenaline and related substances on respiration. J. Physiol. 69:493–499.

    PubMed  CAS  Google Scholar 

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Paterson, D.J., Nye, P.C.G. (1994). Reflexes Arising from the Arterial Chemoreceptors. In: O’Regan, R.G., Nolan, P., McQueen, D.S., Paterson, D.J. (eds) Arterial Chemoreceptors. Advances in Experimental Medicine and Biology, vol 360. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2572-1_7

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