Abstract
Early successes with the transplantation of umbilical cord blood have prompted considerable investigation of this stem cell source. Numerous laboratory investigators have subsequently confirmed the high frequency of primitive hematopoietic progenitors as well as initiated a description of the functional capacities of the neonatal immune system. As a result of these clinical and laboratory observations, the large-scale banking of umbilical cord blood for future transplantation has been initiated worldwide.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Moore MAS, Metcalf D: Ontogeny of the haematopoietic system: Yolk sac origin in vivo and in vitro colony forming cells in the developing mouse embryo. Br J Haematol 18: 279–285, 1970.
Nathan DG, Housman DE, Clarke BJ: The anatomy and physiology of hematopoiesis. In Nathan DG, Oski FA (eds): Hematology of Infancy and Childhood. Philadelphia: WB Saunders, 1981, pp 144–167.
Knudtzon S: In vitro growth of granulocyte colonies from circulating cells in human cord blood. Blood 43:357–361, 1974.
Gabutti V, Foa R, Mussa F, Aglietta M: Behavior of human hematopoietc stem cells in cord and neonatal blood. Haematologica 4:60, 1975.
Broxmeyer HE, Douglas GW, Hangoc G, Cooper S, Bard J, English D, Arny M, Thomas L, Boyse EA: Human umbilical cord blood as a potential source of transplantable hematopoietic stem/progenitor cells. Proc Natl Acad Sci USA 86:3828–3832, 1989.
Broxmeyer HE, Hangoc G, Cooper S, Riberiro RC, Graves V, Yoder M, Wagner J, Vadhad-Raj S, Rubinstein P, Broun ER: Growth characteristics and expansion of human umbilical cord blood and estimation of its potential for transplantation of adults. Proc Natl Acad Sci USA 89:4109–4113, 1992.
Wagner JE, Kernan NA, Broxmeyer HE, Gluckman E: Allogeneic umbilical cord blood transplantation: Report of results in 26 patients. Bood 82:86, 1993.
Wagner JE: Umbilical cord blood transplantation: Overview of the clinical experience. Blood Cells, 1994, in press.
Broxmeyer HE, Kurtzberg J, Gluckman E, Auerbach AD, Douglas G, Cooper S, Falkenberg JHF, Bard J, Boyse EA: Umbilical cord blood hematopoietic stem and repopulating cells in human clinical transplantation. Blood Cells 17:313–329, 1991.
Gluckman E, Broxmeyer HE, Auerbach AD, Friedman H, Douglas GW, Devergie A, Esperou H, Thierry D, Socie G, Lehn P, Cooper S, English D, Kurtzberg J, Bard J, Boyse EA: Hematopoietic reconstitution in a patient with Fanconi’s anemia by means of umbilical cord blood from an HLA-identical sibling. N Engl J Med 321:1174–1178, 1989.
Vilmer E, Sterkers G, Rahimy C, Elion J, Broyart A, Lescoeur B, Gerota J, Blot P: HLA-mismatched cord blood transplantation in a patient with advanced leukemia. Transplantation 53:1155–1157, 1992.
Wagner JE, Broxmeyer HE, Byrd RL, Zehnbauer B, Schmeckpeper B, Shah N, Griffin C, Emanuel PD, Zuckerman KS, Cooper S, Carow C, Bias W, Santos GW: Transplantation of umbilical cord blood after myeloablative therapy: Analysis of engraftment. Blood 79:1874–1881, 1992.
Vowels MR, Lam-PO-Tang R, Berdoukas V, Ford D, Thierry D, Purtilo D, Gluckman E: Brief report: Correction of X-linked lymphoproliferative disease by transplantation of cord-blood stem cells. N Engl J Med 329:1623–1625, 1993.
Bogdanic V, Nemet D, Kastelan A, Latin V, Petrovecki M, Brkljacic-Surlakovic L, Kerki-Brkljacic V, Aurer I, Konja J, Mrsic M, Kalenic S, Labar B: Umbilical cord blood transplantation in a patient with Philadelphia-chromosome positive chronic myeloid leukemia. Transplantation 56:477–479, 1993.
Wagner JE, Broxmeyer HE, Cooper S: Umbilical cord and placental blood hematopoietic stem cells: Collection, cryopreservation and storage. J Hematother 1:167–173, 1992.
Turner CW, Luzins J, Hutcheson C: A modified harvest technique for cord blood hematopoietic stem cells. Bone Marrow Transplant 10:89–91, 1992.
Harris DT, Schumacher MJ, Rychlik S, Booth A, Acevedo A, Rubinstein P, Bard J, Boyse EA: Collection, separation and cryopreservation of umbilical cord blood for use in transplantation. Bone Marrow Transplant 13:135–143, 1994.
Bertolini F, Lazzari L, Lauri E, Corsini C, Castelli C, Gorini F, Sirchia G: A comparative study of different procedures for the collection and banking of umbilical cord blood. J Hematother 4:29–38, 1995.
Newton I, Charbord P, Schaal JP, Herve P: Toward cord blood banking: Density-separation and cryopreservation of cord blood progenitors. Exp Hematol 21:671–674, 1993.
Nagler A, Peacock M, Tantoco M, Lamons D, Okarma TB, Okrongly DA: Separation of hematopoietic progenitor cells from human umbilical cord blood. J Hematother 2:243–245, 1993.
Rubinstein P, Rosenfield RE, Adamson JW, Stevens CE: Review: Stored placental blood for unrelated bone marrow reconstitution. Blood 81:1679–1690, 1993.
Gluckman E, Wagner J, Hows J, Kernan N, Bradley B, Broxmeyer HE: Cord blood banking for hematopoietic stem cell transplantation: An international cord blood transplant registry. Bone Marrow Transplant 11:199–200, 1993.
Kurtzberg J, Casey J, Miller S, Olsen J, Ciocci G, Graham MJ, Stevens C, Rubinstein P: Alternative transplantation of umbilical cord blood cells in pediatric patients. Exp Hematol 22:689, 1994.
Oski FA: The Hematological aspects of the maternal-fetal relationship. In Oski FA, Naiman JL (eds): Hematologic Problems in the Newborn. Philadelphia: WB Saunders, 1982, pp 32–55.
Socié G, Gluckman E, Carosella E, Brossard Y, Lafon C, Brison O: Search for maternal cells in human umbilical cord blood by polymerase chain reaction by amplification of two minisatellite sequences. Blood 83:340–344, 1994.
Saeland S, ouvert V, Caux C, Pandrau D, Favre C, Valle A, Durand I, Charbord P, de Vries J, Banchereau J: Distribution of surface-membrane molecules on bone marrow and cord blood CD34+ hematopoietic cells. Exp Hematol 20:24–33, 1992.
Verfaillie C, Blakolmer K, McGlave P: Purified primitive human hematopoietic progenitor cells with long-term in vitro repopulating capacity adhere selectively to irradiated bone marrow stroma. J Exp Med 172:509, 1990.
Srour EF, Brandt JE, Briddell RA, Grigsby S, Leemhuis T, Hoffman R: Long-term generation and expansion of human primitive hematopoietic progenitor cells in vitro. Blood 81:661–669, 1993.
Traycoff CM, Abboud MR, Laver J, Brandt JE, Hoffman R, Law P, Ishizawa L, Srour EF: Evaluation of the in vitro behavior of phenotypically defined populations of umbilical cord blood hematopoietic progenitor cells. Exp Hematol 22:215–222, 1994.
Dugan MJ, Han CS, McGlave PB: Committed and primitive progenitor content of umbilical cord blood CD34+ subpopulations. Exp Hematol 22:791, 1994.
Moore MAS: Ex vivo expansion and gene therapy using cord blood CD34+ cells. J Hematother 2:221–224, 1993.
Cardoso AA, Li ML, Hatzfeld A, Brown EL, Levesque JP, Sookdeo H, Batard P, Clark SC, Hatzfeld J: Release from quiescence of CD34+ CD38— human umbilical cord blood cells reveals their potentiality to engraft adults. Proc Natl Acad Sci USA 90:8707–8712, 1993.
Verfaillie CM: Direct contact between primitive hematopoietic progenitors and bone marrow stroma is not required for long term in vitro hematopoiesis. Blood 79:2821–2826, 1992.
Verfaillie CM: Soluble factor(s) produced by human bone marrow stroma increase cytokine induces proliferation and maturation of primitive hematopoietic progenitors while preventing their terminal differentiation. Blood 82:2045–2054, 1993.
Verfaillie CM: MlP-la combined with IL3 conserves primitive human LTBMC-IC for at least 8 weeks in ex vivo’ stroma non-contact’ cultures. J Exp Med 179:643–649, 1994.
Han CS, Dugan MJ, Verfaillie CM, Wagner JE, McGlave PB: In vitro expansion of umbilical cord blood committed and primitive progenitors. Exp Hematol 22:723a, 1994.
Rainaut M, Pagniez M, Hercend T, Dafos F, Forestier F: Characterization of mononuclear cell subpopulations in normal fetal peripheral blood. Human Immunol 18:331–337, 1987.
Hannet I, Erkeller-Yuksel F, Lydyard P, Deneys V, DeBruyere M: Developmental and maturational changes in human blood lymphocyte subpopulations. Immunol Today 13:215–218, 1992.
Clement LT, Vink PE, Bradley GE: Novel immunoregulatory functions of phenotypically distinct subpopulations of CD4+ cells in the human neonate. J Immunol 145:102–108, 1990.
Roncarolo MG, Bigler M, Ciuti E, Martino S, Tovo P-A: Immune responses by cord blood cells. Blood Cells, 1994, in press.
Risdon G, Gaddy J, Stehman FB, Broxmeyer HE: Proliferative and cytotoxic responses of human cord blood T lymphocytes following allogeneic stimulation. Cell Immunol 154: 14–24, 1994.
Boyse EA, Broxmeyer HE, Douglas AW: Preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood. U.S. Patent number 5,004,681 issued April 2, 1992; assigned to Biocyte Corporation.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1995 Springer Science+Business Media New York
About this chapter
Cite this chapter
Wagner, J.E. (1995). Umbilical Cord Blood Stem Cell Transplantation. In: Buckner, C.D., Clift, R.A. (eds) Technical and Biological Components of Marrow Transplantation. Cancer Treatment and Research, vol 76. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2013-9_8
Download citation
DOI: https://doi.org/10.1007/978-1-4615-2013-9_8
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-5832-9
Online ISBN: 978-1-4615-2013-9
eBook Packages: Springer Book Archive