Abstract
The superfamily of G-protein–coupled receptors encompasses over 300 cloned and sequenced members, and this number is still rapidly growing. Among them are the adenosine receptor subtypes—A1, A2a, A2b, and A3—some of which originate from various species. Adenosine receptors also show the characteristic secondary structure of all G-protein–coupled receptors, that is, seven predominantly hydrophobic stretches of 20–25 amino acids that could span the cell membrane as a-helices (Fig. 4–1)[1–3]. There is much uncertainty about the atomic coordinates of the receptor proteins. At present we have to rely on their suggested three-dimensional structural analogy with the related membrane proteins, rhodopsin and bacteriorhodopsin. Only the latter protein has been analyzed at sufficient resolution [4] to allow its use as a template for receptor models [5].
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IJzerman, A.P., van der Wenden, N.M., van Galen, P.J.M., Jacobson, K.A. (1995). Molecular Modeling of Adenosine A1 and A2a Receptors. In: Belardinelli, L., Pelleg, A. (eds) Adenosine and Adenine Nucleotides: From Molecular Biology to Integrative Physiology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2011-5_4
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DOI: https://doi.org/10.1007/978-1-4615-2011-5_4
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