Abstract
This chapter describes the combined effects of noradrenaline (NA) and potassium (K+) on carotid body discharge at different levels of \({P_{{O_2}}}\). We used an equation derived from that of Lloyd and Cunningham4,9 for the description of the ventilatory responses of man to hypercapnia and hypoxia. In 1963 Lloyd et al. demonstrated that noradrenaline (NA) increases ventilation in man and described its effect mathematically5. Later it was shown that K+ increases carotid body discharge 2,3 and that the effect of K+ is more pronounced in hypoxia 3. In exercise the hypoxic sensitivity of the carotid body is increased 1,11. Is this due to modulation by sympathetic efferent nerves, by circulating compounds or by central potentiation?
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Heinert, G., Paterson, D.J., Bisgard, G.E., Xia, N., Painter, R., Nye, P.C.G. (1995). The Excitation of Carotid Body Chemoreceptors of the Cat by Potassium and Noradrenaline. In: Semple, S.J.G., Adams, L., Whipp, B.J. (eds) Modeling and Control of Ventilation. Advances in Experimental Medicine and Biology, vol 393. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1933-1_61
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DOI: https://doi.org/10.1007/978-1-4615-1933-1_61
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