Mechanisms of Lymphocyte Activation and Immune Regulation VIII

1. Front Matter

   Pages i-viii

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2. Basic Mechanisms

   1. Delineation of the Pathogenesis of Systemic Lupus Erythematosus by Using Murine Models

      • Kui Liu, Edward K. Wakeland

      Pages 1-6

   2. Factors Contributing to Autoimmune Disease

      • Kristine M. Garza, Linh T. Nguyen, Russell G. Jones, Pamela S. Ohashi

      Pages 7-19

   3. Control of Autoimmunity by Regulatory T Cells

      • Ethan M. Shevach, Rebecca S. McHugh, Angela M. Thornton, Ciriaco Piccirillo, Kannan Natarajan, David H. Margulies

      Pages 21-32

   4. Autoimmunity, Self-Tolerance and Immune Homeostasis: From Whole Animal Phenotypes to Molecular Pathways

      • Christopher C. Goodnow, Richard Glynne, Srini Akkaraju, Jane Rayner, David Mack, James I. Healy et al.

      Pages 33-40

   5. Peripheral Tolerance and Organ Specific Autoimmunity

      • Harald von Boehmer, Elmar Jaeckel

      Pages 41-48

   6. Autoimmune Lymphoproliferative Syndrome: Types I, II and Beyond

      • Hyung J. Chun, Michael J. Lenardo

      Pages 49-57

3. Pathogenesis

   1. The Role of MHC Class II Molecules in the Pathogenesis and Prevention of Type I Diabetes

      • Hugh McDevitt

      Pages 59-66

   2. Control of Autoreactive T Cell Activation by Immunoregulatory T Cells (Art)

      • Jean-François Bach

      Pages 67-77

   3. Immune Tolerance and the Nervous System

      • David E. Anderson, David A. Hafler

      Pages 79-98

   4. Functional Role of Epitope Spreading in the Chronic Pathogenesis of Autoimmune and Virus-Induced Demyelinating Diseases

      • Stephen D. Miller, Todd N. Eagar

      Pages 99-107

4. Therapy

   1. Multiple Sclerosis and Gene Expression Profiling

      • Lawrence Steinman

      Pages 109-112

   2. Treatment of Autoimmunity by Inhibition of T Cell Costimulation

      • David I. Daikh, David Wofsy

      Pages 113-117

   3. Cytokine Blockade in Rheumatoid Arthritis

      • Marc Feldmann, Ravinder N. Maini, Jan Bondeson, Peter Taylor, Brian M. J. Foxwell, Fionula M. Brennan

      Pages 119-127

5. Back Matter

   Pages 129-136

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Advances in biochemistry, cell biology, genome-wide mutagenesis - coupled with molecular technology, including gene microarray and transgenic and knock-out animals - have been instrumental in understanding the cellular processes and molecular pathways of self-tolerance and autoimmune diseases. The molecular definition of these pathways and processes has led to novel treatments for certain auto-immune diseases that are based on the pathogenesis of diseases rather than on broad-spectrum immunosuppression. This book reviews many of these current developments and proposes future novel approaches for understanding the pathogenesis of auto-immune diseases and designing novel therapy. This book covers three major areas of auto-immunity: the basic mechanisms of immunological tolerance, pathogenesis of auto-immune diseases, and some novel therapies.
This book should be useful for immunologists, molecular biologists, rheumatologists, and clinical scientists.

• T cell
• autoimmune disease
• autoimmunity
• biochemistry
• biology
• cell
• cell biology
• cytokine
• diseases
• gene expression
• immunosuppression
• pathogenesis
• virus

• University of California, Irvine, Irvine, USA

  Sudhir Gupta

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