Abstract
Previous research has shown that a sex-related difference exists in the casual level of meibomian gland lipids on the lid margin, with women having lower amounts than men from puberty to menopause.1 We hypothesize that this difference may possibly reflect a gender-associated variation in gene expression, and consequent function, of the meibomian gland. Moreover, we hypothesize that this sex-related difference may relate in part to the influence of androgens, which are known to modulate the meibomian gland.2–9 The purpose of this study was to begin to test these hypotheses.
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References
Chew CKS, Hykin PG, Janswijer C, Dikstein S, Tiffany JM, Bron AJ. The casual level of meibomian lipids in humans. Curr Eye Res 1993;12:255–259.
Sullivan DA, Wickham LA, Rocha EM, Krenzer KL, Sullivan BD, Steagall R, Cermak JM, Dana MR, Ullman MD, Sato EH, Gao J, Rocha FJ, Ono M, Silveira LA, Lambert RW, Kelleher RS, Tolls BD, Toda I. Androgens and dry eye in Sjögren’s syndrome. Ann NY Acad Sci 1999;876:312–324.
Sullivan DA, Sullivan BD, Ullman MD, Rocha EM, Krenzer KL, Cermak JM, Toda I, Doane M, Evans JE, Wickham LA. Androgen influence on the meibomian gland. Invest Ophthalmol Vis Sci 2000; 41:3732–3742.
Rocha EM, Wickham LA, Silveira LA, Krenzer KL, Yu FS, Toda I, Sullivan BD, Sullivan DA. Identification of androgen receptor protein and 5a-reductase mRNA in human ocular tissues. Brit J Ophthalmol 2000;84:76–84.
Krenzer KL, Dana MR, Ullman MD, Cermak JM, Tolls BD, Evans JE, Sullivan DA. Effect of androgen deficiency on the human meibomian gland and ocular surface. J Clin Endocr Metab 2000; 85:4874–4882.
Sullivan BD, Evans JE, Krenzer KL, Dana MR, Sullivan DA. Impact of anti-androgen treatment on the fatty acid profile of neutral lipids in human meibomian gland secretions. J Clin Endocr Metab 2000; 85:4866–4873.
Steagall RJ, Yamagami H, Wickham LA, Sullivan DA. Androgen control of gene expression in the rabbit meibomian gland. Adv Exp Med Biol 2001; in press.
Yamagami H, Schirra F, Liu M, Richards SM, Sullivan BD, Sullivan DA. Androgen influence on gene expression in the meibomian gland. Adv Exp Med Biol 2001; in press.
Zeligs MA, Gordon K. Dehydroepiandrosterone therapy for the treatment of dry eye disorders. Int Patent Application WO 94/04155, March, 1994.
He WW, Kumar MV, Tindall DJ. A frame-shift mutation in the androgen receptor gene causes complete androgen insensitivity in the testicular-feminized mouse. Nucleic Acids Res 1991; 19:2373–2378.
Richards SM, Sullivan BD, Liu M, Sullivan D. Effect of gender on gene expression in the mouse lacrimal gland. Manuscript submitted, 2001.
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Yamagami, H., Richards, S.M., Sullivan, B.D., Liu, M., Steagall, R.J., Sullivan, D.A. (2002). Gender-Associated Differences in Gene Expression of the Meibomian Gland. In: Sullivan, D.A., Stern, M.E., Tsubota, K., Dartt, D.A., Sullivan, R.M., Bromberg, B.B. (eds) Lacrimal Gland, Tear Film, and Dry Eye Syndromes 3. Advances in Experimental Medicine and Biology, vol 506. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0717-8_64
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DOI: https://doi.org/10.1007/978-1-4615-0717-8_64
Publisher Name: Springer, Boston, MA
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