Abstract
One of the main functions of the lacrimal gland is the regulated secretion of tear fluid, rich in proteins and electrolytes, in response to signals provided through the sympathetic and parasympathetic nervous system. Since proper tear-fluid secretion is essential for maintenance of ocular health, a long-term focus of our laboratory has been to understand the molecular mechanisms governing regulated secretion in lacrimal acini. In particular, we have focused on the role of microtubules (MTs), actin-based microfilaments (MFs), and motor proteins associated with either filament system in the stimulated lacrimal acinar secretory response. MTs and MFs constitute two of the three major cytoskeletal filament systems in mammalian cells, the third system being the intermediate filaments.
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© 2002 Kluwer Academic/Plenum Publishers
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da Costa, S.R., Andersson, S., Yarber, F.A., Okamoto, C., Hamm-Alvarez, S. (2002). Cytoskeletal Participation in Stimulated Secretion and Compensatory Apical Plasma Membrane Retrieval in Lacrimal Gland Acinar Cells. In: Sullivan, D.A., Stern, M.E., Tsubota, K., Dartt, D.A., Sullivan, R.M., Bromberg, B.B. (eds) Lacrimal Gland, Tear Film, and Dry Eye Syndromes 3. Advances in Experimental Medicine and Biology, vol 506. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0717-8_26
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DOI: https://doi.org/10.1007/978-1-4615-0717-8_26
Publisher Name: Springer, Boston, MA
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