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Central Nervous System: The Brain and Cerebrospinal Fluid

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Pediatric Nuclear Medicine and Molecular Imaging

Abstract

This chapter will review methodology of single photon emission computed tomography (SPECT) and positron emission tomography (PET), radiopharmaceuticals, imaging instrumentation, image fusion, and clinical applications in children. Both SPECT and PET can depict regional cerebral perfusion, glucose metabolism, and other functions and provide images of the location, quantification, and biokinetics of radiopharmaceutical agents. In addition, these techniques can detect rapid changes due to normal brain activity in different functional conditions or those caused by pharmacologic or cognitive stimulation. Improvements in the production and distribution of 18F-FDG and better PET systems have facilitated the widespread use of PET. Advances in imaging systems and data processing in SPECT have resulted in systems that are simpler to operate and that yield 3D images of high functional and anatomic resolution.

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Authors and Affiliations

  1. Joint Program in Nuclear Medicine, Department of Radiology, Harvard Medical School, Boston, MA, USA

    S. Ted Treves MD

  2. Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Boston Children’s Hospital, Boston, MA, USA

    S. Ted Treves MD

  3. Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Brigham and Women’s Hospital, Boston, MA, USA

    S. Ted Treves MD

  4. Department of Neurology, PET Center, Children’s Hospital of Michigan, Detroit, MI, USA

    Harry T. Chugani MD

  5. Department of Neurology, Boston Children’s Hospital, Boston, MA, USA

    Blaise F. D. Bourgeois MD

  6. Global Macro GFX, Investment Banking, Credit Suisse, London, UK

    Alvin Kuruc MD, PhD

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    S.Ted. Treves

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Treves, S.T., Chugani, H.T., Bourgeois, B.F.D., Kuruc, A. (2014). Central Nervous System: The Brain and Cerebrospinal Fluid. In: Treves, S. (eds) Pediatric Nuclear Medicine and Molecular Imaging. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-9551-2_4

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