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The Presence of Venous Damage and Microbleeds in Traumatic Brain Injury and the Potential Future Role of Angiographic and Perfusion Magnetic Resonance Imaging

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Cerebral Blood Flow, Metabolism, and Head Trauma

Abstract

Imaging plays a key role in the diagnosis and longitudinal follow up of traumatic brain injury (TBI). Among injury pathologies, vascular injury is associated with diffuse axonal injury (DAI) and traumatic axonal injury (TAI). The vascular network is ubiquitous and is an integral part of the tissue structure. In this chapter, we focus on angiographic and venographic-related imaging methods and their role in assessing mild, moderate, and severe TBI. We begin with an introduction to susceptibility weighted imaging (SWI) and magnetic resonance angiography (MRA) and then provide evidence of different types of vascular damage. Examples of TBI-induced microbleeds are presented along with the concept of low-impact medullary vein damage (MVD). This MVD has been seen even for so-called mild TBI cases. Vascular damage can also manifest as a reduction in local perfusion even when no clear macroscopic vessel damage is seen. To further understand the role of vascular abnormalities, we then introduce the different perfusion weighted imaging (PWI) techniques available and their application in TBI. The combination of SWI and PWI should make it possible to differentiate the role of local thrombus versus changes in oxygen saturation in MVD, for example. Since MRA and SWI are able to provide a full description of the brain’s vasculature in 3D, we briefly discuss the presence of finite element modeling in understanding vascular injury. We conclude with recommendations related to the use of perfusion with MRA, SWI, and oxygen saturation measurements to obtain a complete picture of the hemodynamics of the brain.

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Acknowledgments

We would like to thank Sagar Bush for Fig. 4.8, Tang Jin for Fig. 4.7, Meng Li for Fig. 4.5, and Yongquan Ye for Fig. 4.4, and to Yongquan Ye for reviewing the chapter and Liying Zhang for reviewing the section on finite element methods for studying brain trauma.

This work was supported in part by a grant from the Telemedicine and Advanced Technology Research Center (W81XWH-11-1-0493) and the National Institutes of Health, National Heart and Blood Institute (HL62983).

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Authors and Affiliations

  1. Department of Radiology, Wayne State University, Detroit, MI, 48201, USA

    E. M. Haacke PhD, Waqar Raza MS, Bo Wu BS & Zhifeng Kou PhD

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  1. E. M. Haacke PhD
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  2. Waqar Raza MS
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  3. Bo Wu BS
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  4. Zhifeng Kou PhD
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Correspondence to E. M. Haacke PhD .

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  1. , Health Science Specialist, John D. Dingell VA Medical Center, 4646 John R Street, Detroit, 48201, Michigan, USA

    Christian W. Kreipke

  2. School of Medicine, Anatomy and Cell Biology, Wayne State University, 540 East Canfield, Detroit, 48201, Michigan, USA

    Jose A. Rafols

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Haacke, E.M., Raza, W., Wu, B., Kou, Z. (2013). The Presence of Venous Damage and Microbleeds in Traumatic Brain Injury and the Potential Future Role of Angiographic and Perfusion Magnetic Resonance Imaging. In: Kreipke, C., Rafols, J. (eds) Cerebral Blood Flow, Metabolism, and Head Trauma. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-4148-9_4

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