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Medium to High Throughput Screening: Microfabrication and Chip-Based Technology

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Book cover New Technologies for Toxicity Testing

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 745))

Abstract

Medium to high throughput screening for toxicity testing can provide a wealth of information with significant time and cost savings. New technologies, such as microfabrication, microfluidics and chip-based technology, combined with advanced cell culture and detection techniques, open up new opportunities in toxicity testing. In this chapter, fundamentals of microfabrication and microfluidics are discussed with a focus on the broad and novel applications on toxicity studies enabled by these technologies. Emphasis is placed on microscale cell and tissue culture models for medium and high throughput systemic toxicity studies in vitro.

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Authors and Affiliations

  1. William G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, Ohio, USA

    Yuan Wen, Xudong Zhang & Shang-Tian Yang

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  1. Yuan Wen
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  2. Xudong Zhang
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  3. Shang-Tian Yang
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Correspondence to Shang-Tian Yang .

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  1. FRAME, Nottingham, UK

    Michael Balls DPhil

  2. Norwich, UK

    Robert D. Combes PhD (Independent Consultant) (Independent Consultant)

  3. Nottingham, UK

    Nirmala Bhogal PhD (Independent Consultant) (Independent Consultant)

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Wen, Y., Zhang, X., Yang, ST. (2012). Medium to High Throughput Screening: Microfabrication and Chip-Based Technology. In: Balls, M., Combes, R.D., Bhogal, N. (eds) New Technologies for Toxicity Testing. Advances in Experimental Medicine and Biology, vol 745. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-3055-1_11

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