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Therapeutic Cloning and Cellular Reprogramming

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Stem Cell Transplantation

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 741))

Abstract

Embryonic stem cells are capable of differentiating into any cell-type present in an adult organism, and constitute a renewable source of tissue for regenerative therapies. The transplant of allogenic stem cells is challenging due to the risk of immune rejection. Nevertheless, somatic cell reprogramming techniques allow the generation of isogenic embryonic stem cells, genetically identical to the patient. In this chapter we will discuss the cellular reprogramming techniques in the context of regenerative therapy and the biological and technical barriers that they will need to overcome before clinical use.

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Author information

Authors and Affiliations

  1. Cancer Epigenetics Laboratory, Instituto Universitario de Oncología del Principado de Asturias (IUOPA), HUCA, Universidad de Oviedo, Oviedo, Spain

    Ramon M. Rodriguez

  2. Department of Animal Science, University of California-Davis, Davis, California, USA

    Pablo J. Ross

  3. Cellular Reprogramming Laboratory, Department of Animal Science, Michigan State University, East Lansing, Michigan, USA

    Jose B. Cibelli

  4. Department of Physiology, Michigan State University, East Lansing, Michigan, USA

    Jose B. Cibelli

  5. Andalusian Cell Therapy and Regenerative Medicine Programme, Andalusia, Spain

    Jose B. Cibelli

Authors
  1. Ramon M. Rodriguez
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  2. Pablo J. Ross
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  3. Jose B. Cibelli
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Corresponding author

Correspondence to Jose B. Cibelli .

Editor information

Editors and Affiliations

  1. Department of Immunology, Hospital Universitario Central de Asturias, Oviedo, Spain

    Carlos López-Larrea PhD , Antonio López-Vázquez MD  & Beatriz Suárez-Álvarez PhD ,  & 

  2. Fundación Renal Iñigo Alvarez de Toledo, Madrid, Spain

    Carlos López-Larrea PhD

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© 2012 Landes Bioscience and Springer Science+Business Media

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Rodriguez, R.M., Ross, P.J., Cibelli, J.B. (2012). Therapeutic Cloning and Cellular Reprogramming. In: López-Larrea, C., López-Vázquez, A., Suárez-Álvarez, B. (eds) Stem Cell Transplantation. Advances in Experimental Medicine and Biology, vol 741. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-2098-9_18

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