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Modulation of T-Cell Mediated Immunity by Cytomegalovirus

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Control of Innate and Adaptive Immune Responses during Infectious Diseases

Abstract

The herpesviruses have coevolved with their vertebrate hosts for over one hundred million years (McGeoch et al. 2000), resulting in a finely tuned equilibrium with the immune system. Consequently, all herpesviruses employ a multitude of strategies to modulate the host immune response, facilitating the establishment of lifelong latency and/or persistence in the face of a robust innate and adaptive immune response. Cytomegalovirus (CMV, a β-herpesvirus) is the largest of the herpesviruses, with a genome of ∼230 kB in size encoding >200 open reading frames (orfs). Approximately ∼60% of the encoded genes are not essential for replication of virus in tissue culture where there is no selective pressure from the host immune system and are predicted to perform immunomodulatory functions and facilitate establishment of latency (Murphy et al. 2003; Brocchieri et al. 2005). CMV directly targets dendritic cells (DC) and exploits the DC’s crucial role in the regulation of innate and adaptive anti-viral immune responses to promote replication and establish latency while preventing host pathology.

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Author information

Authors and Affiliations

  1. Division of Immune Regulation, La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA

    Chris A. Benedict

  2. Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA

    Ramon Arens

  3. Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA

    Andrea Loewendorf

  4. Division of Molecular Immunology, Cincinnati Children’s Hospital Research Foundation, University of Cincinnati College of Medicine, Cincinnati, OH, USA

    Edith M. Janssen

Authors
  1. Chris A. Benedict
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  2. Ramon Arens
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  3. Andrea Loewendorf
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  4. Edith M. Janssen
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Corresponding authors

Correspondence to Chris A. Benedict or Edith M. Janssen .

Editor information

Editors and Affiliations

  1. Medical Center, Div. Pulmonary Medicine, Cincinnati Children’s Hospital, Burnet Ave. 3333, Cincinnati, 45229-3039, Ohio, USA

    Julio Aliberti

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© 2012 Springer Science+Business Media LLC

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Benedict, C.A., Arens, R., Loewendorf, A., Janssen, E.M. (2012). Modulation of T-Cell Mediated Immunity by Cytomegalovirus. In: Aliberti, J. (eds) Control of Innate and Adaptive Immune Responses during Infectious Diseases. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-0484-2_7

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