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Current Topics in Innate Immunity II pp 223–235Cite as

Function of Act1 in IL-17 Family Signaling and Autoimmunity

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 946))

Abstract

The maintenance of immune homeostasis requires the delicate balance between response to foreign antigens and tolerance to self. As such, when this balance is disrupted, immunodeficiency or autoimmunity may manifest. The adaptor molecule known as Act1 is a critical mediator of IL-17 receptor family signaling. This chapter will detail the current understanding of Act1 ’s role in signal transduction as well as address the fundamental role of Act1 in autoimmunity. At the molecular level Act1 interacts with IL-17 R through the conserved SEFIR domain, binds TRAF proteins and exerts E3 ubiquitin ligase activity. In in vivo models, Act1 deficiency provides protection against experimental autoimmune diseases, such as colitis and EAE. Yet mice lacking in Act1 develop spontaneous autoimmune diseases. Indeed, the utility of Act1 seems to rely on the specific cell type expression that may determine the pathway that Act1 mediates.

Ling Wu and Jarod Zepp contributed equally to this book chapter.

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Authors and Affiliations

  1. Department of Immunology, Cleveland Clinic Foundation, 44195, Cleveland, OH, USA

    Ling Wu, Jarod Zepp & Xiaoxia Li

  2. Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, 44195, Cleveland, OH, USA

    Jarod Zepp

  3. Department of Pathology, Case Western Reserve University, 44106, Cleveland, OH, USA

    Ling Wu

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  1. Ling Wu
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  2. Jarod Zepp
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  3. Xiaoxia Li
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Correspondence to Xiaoxia Li .

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Editors and Affiliations

  1. Department Of Pathology Laboratory Of, Medicine, University Of Pennsylvania, Johnson Pavilion 410, Philadelphia, 19104, Pennsylvania, USA

    John D. Lambris

  2. Health Sciences Center, University of Louisville, Louisville, 40292, Kentucky, USA

    George Hajishengallis

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Wu, L., Zepp, J., Li, X. (2012). Function of Act1 in IL-17 Family Signaling and Autoimmunity. In: Lambris, J., Hajishengallis, G. (eds) Current Topics in Innate Immunity II. Advances in Experimental Medicine and Biology, vol 946. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-0106-3_13

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