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Hormonal Carcinogenesis II pp 463–466Cite as

Increased Nuclear IGF-1 Receptor Level, Coupled with Attenuation in DNA Repair, Plays an Important Role in Estrogen-Induced Carcinogenesis

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Summary

We have previously shown an increase in the level of plasma membrane IGF-1 receptor (IGF-1R) in DES-induced kidney tumors. In this study, we demonstrate that DES treatment of Syrian hamsters increases the level of renal nIGF-lR by 3.0- to 4.0-fold over control levels, while the transcripts of DNA polymerase β, a repair enzyme, decreased by 8.0- to 10.0-fold in DES-induced kidney tumors compared with control levels. These findings suggest that increased mitogenic signals, through enhanced level of nIGF-lR, coupled with attenuation in the DNA repair system may play an important role in the induction of DES-induced carcinogenesis.

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References

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Authors
  1. Deodutta T. E. Roy
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  2. Chiao-wen Chen
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  3. Zhi-Jie Yan
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Editor information

Editors and Affiliations

  1. Division of Etiology and Prevention of Hormonal Cancers, Hormonal Carcinogenesis Laboratory, University of Kansas Cancer Center, Kansas City, Kansas, USA

    J. Jonathan Li Ph.D. (Professor of Pharmacology, Toxicology, and Therapeutics, Director) (Professor of Pharmacology, Toxicology, and Therapeutics, Director)

  2. Hormonal Carcinogenesis Laboratory, University of Kansas Cancer Center, Kansas City, Kansas, USA

    Sara Antonia Li Ph.D. (Associate Professor of Pharmacology, Toxicology, and Therapeutics) (Associate Professor of Pharmacology, Toxicology, and Therapeutics)

  3. Department of Medical Nutrition, Center for Biotechnology, NOVUM, Huddinge University Hospital, Huddinge, Sweden

    Jan-Åke Gustafsson M.D., Ph.D. (Professor and Chairman, Director) (Professor and Chairman, Director)

  4. Department of Molecular and Cell Biology, Cancer Research Center, University of California, Berkeley, California, USA

    Satyabrata Nandi Ph.D. (Professor of Cell and Development Biology) (Professor of Cell and Development Biology)

  5. Division of Cancer Etiology, Chemical and Physical Carcinogenesis Program, National Cancer Institute, Rockville, Maryland, USA

    Lea I. Sekely Ph.D. (Program Director) (Program Director)

  6. University of Kansas Medical Center, Kansas City, Kansas, USA

    J. Jonathan Li Ph.D. (Professor of Pharmacology, Toxicology, and Therapeutics, Director) & Sara Antonia Li Ph.D. (Associate Professor of Pharmacology, Toxicology, and Therapeutics) (Professor of Pharmacology, Toxicology, and Therapeutics, Director) &  (Associate Professor of Pharmacology, Toxicology, and Therapeutics)

  7. National Institutes of Health, Rockville, Maryland, USA

    Lea I. Sekely Ph.D. (Program Director) (Program Director)

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© 1996 Springer-Verlag New York, Inc.

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Roy, D.T.E., Chen, Cw., Yan, ZJ. (1996). Increased Nuclear IGF-1 Receptor Level, Coupled with Attenuation in DNA Repair, Plays an Important Role in Estrogen-Induced Carcinogenesis. In: Li, J.J., Li, S.A., Gustafsson, JÅ., Nandi, S., Sekely, L.I. (eds) Hormonal Carcinogenesis II. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2332-0_67

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  • DOI: https://doi.org/10.1007/978-1-4612-2332-0_67

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-7506-0

  • Online ISBN: 978-1-4612-2332-0

  • eBook Packages: Springer Book Archive

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