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Anatomical Studies of the Fibroblast Growth Factor-10 Mutant, Sonic Hedge Hog Mutant and Androgen Receptor Mutant Mouse Genital Tubercle

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Hypospadias and Genital Development

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 545))

Abstract

Congenital genital abnormalities have a diverse spectrum from hypospadias to cloacal anomalies. The molecular events in the normal and abnormal development of the genital tubercle (GT) are still obscure. Genetically engineered mice with specific gene deletions that affect genital anatomy are a useful tool to better understand the etiology of genital abnormalities. In this study, we compared the genital tubercle anatomy of the androgen receptor (AR) deficient, fibroblastic growth factor (FGF)-10 deficient and Sonic HedgeHog (Shh) deficient mutant male mice to that of the wild type male and female mouse.

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Authors and Affiliations

  1. Department of Urology, University of California, San Francisco, CA, 94143-0738

    Laurence S. Baskin M.D.

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  1. Selcuk Yucel
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  2. Wenhui Liu
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  3. Dwight Cordero
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  4. Anne Donjacour
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  5. Gerald Cunha
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  6. Laurence S. Baskin M.D.
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  1. University of California, San Francisco, San Francisco, California, USA

    Laurence S. Baskin

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Yucel, S., Liu, W., Cordero, D., Donjacour, A., Cunha, G., Baskin, L.S. (2004). Anatomical Studies of the Fibroblast Growth Factor-10 Mutant, Sonic Hedge Hog Mutant and Androgen Receptor Mutant Mouse Genital Tubercle. In: Baskin, L.S. (eds) Hypospadias and Genital Development. Advances in Experimental Medicine and Biology, vol 545. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-8995-6_8

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  • DOI: https://doi.org/10.1007/978-1-4419-8995-6_8

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  • Print ISBN: 978-1-4613-4752-1

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